DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and lrp5

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_009296098.1	Gene:	lrp5 / 568518	ZFINID:	ZDB-GENE-050518-2	Length:	1615	Species:	Danio rerio

Alignment Length:	320	Identity:	64/320 - (20%)
Similarity:	104/320 - (32%)	Gaps:	121/320 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 GGAAPVSGSGAAGFPSSSSSISSSLGPGKPVNLQLAPGSSSTG----CSLAEFSCSNGR--CVPL 229
            ||.:.:..:...|.|..|.          |::|.|.....|.|    ||..:|:|:.|.  |:|:
Zfish  1224 GGCSHICIAKGDGTPRCSC----------PMHLVLLQNLLSCGEPPTCSSEQFTCATGEIDCIPM 1278

  Fly   230 SKYCNNLNDCGDGSDEPRFCTRCNRTYYG-DIGQTYALELH----------RPKQDRVPFVCVLT 283
            :..|:.:.:|.|.|||.. |..|::..:. |.||...:::.          ..:|| ...:|:..
Zfish  1279 AWRCDGIAECADNSDEMN-CPICSKLQFQCDKGQCVDIQVRCNGEPDCADGSDEQD-CETICLSN 1341

  Fly   284 FTAAGGQH---------------------------------------GDVVQVTLDSFTIG---- 305
            ....|...                                       |.|:.:.|..|.:|
Zfish  1342 QFRCGNSQCILKKQQCDSFPDCTDESDERFCDFPPPPNDLPRHTSTIGPVIGIILSVFVMGGMCF 1406

  Fly   306 ---RFTSYVHEGCPDG---YMQIAESARTPIG-----------GMWCG------------SSWGP 341
               |.....::| |:|   :..|:.:...|:.           |:.||            ||.|.
Zfish  1407 VCQRVVCRHYKG-PNGGFPHEYISGTPHVPLNFIAPTNSQHGKGISCGKSMMSSVSLMGSSSSGA 1470

  Fly   342 VLF------------YSETRSLIFTIRLN---RLARDQSGYNFDFRIRYKVLSRDSSVTR 386
            .|:            .|.|:...:...||   ..|.|:|.||.:  :.|.  |...|.||
Zfish  1471 PLYDRNHVTGASSSSSSSTKGAFYPQMLNPPPSPATDRSLYNAE--VFYS--SNSPSTTR 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	11/32 (34%)
		CUB	503..646	CDD:238001
		LDLa	1203..1231	CDD:197566
lrp5	XP_009296098.1	LY	105..147	CDD:214531
		Ldl_recept_b	168..208	CDD:278487
		LY	192..234	CDD:214531
		LY	235..269	CDD:214531
		FXa_inhibition	304..341	CDD:291342
		Ldl_recept_b	390..429	CDD:278487
		LY	413..455	CDD:214531
		LY	456..499	CDD:214531
		LY	501..542	CDD:214531
		LY	544..583	CDD:214531
		FXa_inhibition	610..645	CDD:291342
		LY	674..714	CDD:214531
		LY	717..757	CDD:214531
		LY	758..800	CDD:214531
		LY	802..843	CDD:214531
		LY	845..884	CDD:214531
		FXa_inhibition	911..946	CDD:291342
		LY	974..1013	CDD:214531
		LY	1106..1148	CDD:214531
		FXa_inhibition	1219..1255	CDD:291342	8/40 (20%)
		LDLa	1261..1297	CDD:238060	13/36 (36%)
		LDLa	1300..1334	CDD:238060	6/34 (18%)
		LDLa	1338..1372	CDD:238060	2/33 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900