DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and lrp1ab

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:1297 Identity:247/1297 - (19%)
Similarity:364/1297 - (28%) Gaps:530/1297 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   200 PVNLQLAPGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPR----------------- 247
            |.|||..  .:.:.|:...|.||:|:||..:..|:|.|||||||||..                 
Zfish  2896 PKNLQCT--DTESRCNDTAFLCSSGKCVNETLLCDNNNDCGDGSDENNCFVNECLNSKLSGCSQL 2958

  Fly   248 -------FCTRCNRTYYGDIGQTYALELHRPKQDRVPFV--------------CVLTFTAAGGQH 291
                   |..|||..:             |.|||....|              |:.|       |
Zfish  2959 CEDLKIGFKCRCNAGF-------------RLKQDGKTCVDLDECSTVYPCSQRCINT-------H 3003

  Fly   292 GDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAESARTPIGGMWCGSSWGPVLFYSETRSLIFTIR 356
            |        ||         |..|.||::.      .|.....|.|:      ..|...|||..|
Zfish  3004 G--------SF---------HCLCVDGFVP------RPDDHTSCKST------AEEEPFLIFANR 3039

  Fly   357 --LNRLARDQSGYN-----------FDFR-----IRYKVLSRDSSVTRYGGIKLAELAQWHNRSS 403
              |.:|..|.|.|.           .|:.     |.:..::...|:.|...|..:.:...| |:|
Zfish  3040 YYLRKLNLDGSNYTLIKQGLNNAVALDYHYAEQMIYWTDVTTQGSMIRRMHINGSNVQVLH-RTS 3103

  Fly   404 FLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQD----FSLFSAYANNKTFMASLE 464
            ..|..                  |:..|:...::...|: |:|    ..|..||.:........|
Zfish  3104 LSNPD------------------GLAVDWVGGNLYWCDK-GRDTIEVSKLNGAYRSVLVNSGLRE 3149

  Fly   465 -KSLAKDEQNYTEPKYYL-----GDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIYPRNLT----- 518
             :::|.|.:|     .||     || :|  :..||..|...:...:|...   .:|..||     
Zfish  3150 PRAVAVDVRN-----GYLYWSDWGD-VP--HIGRIGMDGTDRQIIIQDKI---TWPNGLTLDFIN 3203

  Fly   519 --CYYA-------------------VRQHDVPH----------------------------GKHA 534
              .|:|                   |..||:||                            |.:.
Zfish  3204 DRIYWADAREDYIAFASLDGSNRHTVLNHDIPHIFAMTLFEEFIYWTDWETKSINRAHKTLGTNK 3268

  Fly   535 LILV---------------KQPK-------------GNLVWISTQETAAANKMAPPPS---ASDK 568
            .:|:               :||:             .||..:|   .....|.|.|.:   |:|.
Zfish  3269 TLLISTLHRPMDIHIFHPSRQPEVSGHPCQEDNGGCSNLCLLS---PGGGYKCACPTNFYLAADG 3330

  Fly   569 DKKFEPRLKTWNYCDYIQENVK--PKWKSTDYVTVYDGYTTRDPIILKFCGGGQAVPAAVSSGPE 631
                :..|.......::.:|.|  |.|...|         |.|.     ||.....||...    
Zfish  3331 ----KQCLSNCTASQFVCKNDKCIPFWWKCD---------TEDD-----CGDRSDEPADCP---- 3373

  Fly   632 LLVEFSTSPFGTF-TGTSSQVLPLYGFQLEVEVQ--------FVDIQSPTYSKNKKP-------- 679
               ||...| |.| .||.....|.|....:.:.|        .:.:..|:..|...|        
Zfish  3374 ---EFKCRP-GQFQCGTGLCTNPAYICDGDNDCQDNSDEANCDIHVCLPSQFKCSHPSRCIPGIL 3434

  Fly   680 -------CEFWIRGAGRGILESPKHSLAPNS-TCLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQP 736
                   |     |.|....:.|:.:.|||. .|                ::::|...       
Zfish  3435 RCNGQNNC-----GQGEDEKDCPEVTCAPNQFQC----------------AITKRCIP------- 3471

  Fly   737 LSRFKVWISVLKFNLDPEFGQIDETSVGA------IGV-----------------LQTQEDCSGM 778
                :||:      .|.::..:||:...|      .||                 ...::||   
Zfish  3472 ----RVWV------CDRDYDCVDESDEPANCTQMKCGVDEFRCKDSGRCIPSRWTCDGEDDC--- 3523

  Fly   779 LRIWDGTLRDAPV--------------CKDLNCAT---ETSSYNTLGHYTHNSTSVIARFCRGTI 826
                 |...|.|.              ||:..|..   :....|..|..:.....|         
Zfish  3524 -----GDASDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEEKCV--------- 3574

  Fly   827 PRTCDRSNINETYAR------PCTISESYVSTSDAITLELRNTESTVLRPLDFKLKYEFIDLHQD 885
            ||.|..|....:..|      .|.........||....:|:..|.      .|:.|    :.|..
Zfish  3575 PRQCSESEFACSNGRCIAGRWKCDGDHDCSDGSDEDGCDLKCEED------QFQCK----NGHCI 3629

  Fly   886 GLPW-------------------------GGGEHDCNR---KFLSSMMDRKDPAIFRSVRN---I 919
            .|||                         ...|..||.   |.||...|.:|.....|..|   .
Zfish  3630 PLPWRCDADVDCLDGSDEERCEITEVRHCSSEEFQCNNTLCKPLSWKCDGEDDCGDNSDENPEAC 3694

  Fly   920 FLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVDE---------DINRSFCYG-- 973
            ..|....|||.:|       |..||.:...|:......|....||         |.::..|..  
Zfish  3695 RHFQCPPTRNFRC-------RNNRVCLTRSKLCDGVDNCGDNSDEASCDYESTCDKDQFRCTNGK 3752

  Fly   974 --DTNVRIEIF---ERPYHDSILLHRGC--------------MCNSSNQSHLPVEYTSTSRDVEV 1019
              ..|:|...|   |....|.|    ||              :|...:::|.....|.|....:.
Zfish  3753 CISANLRCNFFNDCEDYGSDEI----GCKTDTMLNDCKSNKSLCGDGDEAHCVSNGTDTFCSCKP 3813

  Fly  1020 HFIAQNMTTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGP-SGTIDMTFGDVECRSRPWL----- 1078
            .|.:....|.:|.|               .||    :||. |...:.|.|..:|....:.     
Zfish  3814 GFQSVRHNTCEDKD---------------ECK----QFGVCSHVCNNTKGSYKCSCHKYFTRINH 3859

  Fly  1079 ---IEPSNGNKFLYVRLKAIFLSKHNPTQTLNA-----TYVQT---------DTWRCETKSRAVL 1126
               .:..|.||      :.::::..|..::||.     .|.||         |......|:..:.
Zfish  3860 TCKADGQNSNK------QVLYIADDNEIRSLNPGMPNWVYEQTFQGDNNVRIDAMDLHVKTNRIF 3918

  Fly  1127 TT---SEGLTIVACP-----LSPDSNAYEFVEIFSSGWNERPNFALVNRSRAISVEFLRPGN 1180
            .|   :.|::....|     ..|.||::.... .|.|.........:...|.|:|::: .||
Zfish  3919 WTNWHTYGISCFQLPSQSSASGPTSNSHRHTR-QSEGTVSNLEIPGLKMPRGIAVDWV-AGN 3978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 16/30 (53%)
CUB 503..646 CDD:238001 40/230 (17%)
LDLa 1203..1231 CDD:197566
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 170..198 CDD:317114
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 494..526 CDD:317114
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:317114
LDLa 857..889 CDD:197566
LDLa 899..932 CDD:238060
LDLa 940..971 CDD:238060
LDLa 982..1015 CDD:238060
LDLa 1019..1052 CDD:238060
LDLa 1066..1101 CDD:238060
LDLa 1110..1144 CDD:238060
LDLa 1149..1185 CDD:238060
FXa_inhibition 1188..1224 CDD:317114
LY 1339..1381 CDD:214531
LY 1383..1426 CDD:214531
LY 1437..1470 CDD:214531
LY 1479..1515 CDD:214531
LY 1616..1652 CDD:214531
LY 1653..1696 CDD:214531
LY 1700..1739 CDD:214531
LY 1739..1780 CDD:214531
FXa_inhibition 1853..1889 CDD:317114
LY 1919..1959 CDD:214531
LY 1962..2002 CDD:214531
LY 2003..2046 CDD:214531
LY 2048..2090 CDD:214531
FXa_inhibition 2162..2197 CDD:317114
SGL 2236..2464 CDD:331563
Ldl_recept_b 2346..2387 CDD:278487
LY 2372..2413 CDD:214531
FXa_inhibition 2483..2518 CDD:317114
LDLa 2523..2559 CDD:294076
LDLa 2567..2601 CDD:238060
LDLa 2606..2640 CDD:238060
LDLa <2667..2689 CDD:238060
LDLa 2697..2731 CDD:238060
LDLa 2738..2769 CDD:197566
LDLa 2777..2810 CDD:197566
LDLa 2821..2853 CDD:197566
Ldl_recept_a 2861..2895 CDD:278486
LDLa 2908..2942 CDD:238060 18/33 (55%)
cEGF 2965..2988 CDD:315355 9/35 (26%)
EGF_CA 2985..3019 CDD:214542 10/63 (16%)
LY 3052..3096 CDD:214531 6/43 (14%)
LY 3097..3139 CDD:214531 11/61 (18%)
LY 3141..3183 CDD:214531 12/49 (24%)
LY 3184..3226 CDD:214531 6/44 (14%)
LY 3227..3267 CDD:214531 6/39 (15%)
FXa_inhibition 3297..3333 CDD:317114 8/42 (19%)
LDLa 3337..3368 CDD:238060 9/44 (20%)
LDLa 3377..3411 CDD:238060 8/34 (24%)
LDLa 3416..3451 CDD:238060 6/39 (15%)
LDLa 3455..3488 CDD:197566 10/65 (15%)
LDLa 3496..3529 CDD:197566 5/40 (13%)
LDLa 3539..3573 CDD:238060 5/33 (15%)
LDLa 3578..3612 CDD:238060 6/33 (18%)
LDLa 3616..3650 CDD:238060 7/43 (16%)
LDLa 3658..3690 CDD:238060 9/31 (29%)
LDLa 3699..3735 CDD:238060 11/42 (26%)
LDLa 3741..3776 CDD:238060 8/38 (21%)
EGF_CA 3825..3855 CDD:214542 10/48 (21%)
LY 3963..3999 CDD:214531 5/17 (29%)
Ldl_recept_b 4020..4060 CDD:278487
LY 4044..4085 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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