DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32432 and LRP1B

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:1100 Identity:207/1100 - (18%)
Similarity:321/1100 - (29%) Gaps:386/1100 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDE---------------------------- 245
            |:...|:.:.|.|.||||:|....|:|.:||||||||                            
Human  2886 SAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYK 2950

  Fly   246 ----PRF------------------------CTRCNRTYYGDIGQTYALELHRPK-----QDRVP 277
                |.|                        |.....||.......|.::...|.     .|..|
Human  2951 CKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEP 3015

  Fly   278 FVCVLTFTAAGGQHGDVVQVTLD--SFTI----------------GRFTSYVHEGCPDGY----- 319
            |:.:       ..|.::.:::.|  ::|:                ..|..::....|:|.     
Human  3016 FLIL-------ADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRM 3073

  Fly   320 ------MQIAESARTP--IGGMWCGSSWGPVLFYSETRSLIFTI-RLNRLARDQSGYNFDFRIRY 375
                  :::..:...|  :...|.|.:    |::|:|...|..: :||.|      |......:.
Human  3074 CLNGSDIKVVHNTAVPNALAVDWIGKN----LYWSDTEKRIIEVSKLNGL------YPTILVSKR 3128

  Fly   376 KVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARS 440
            ....||.|:....|     ...|.:...:                ...|..|:  |.||.||...
Human  3129 LKFPRDLSLDPQAG-----YLYWIDCCEY----------------PHIGRVGM--DGTNQSVVIE 3170

  Fly   441 DRYGQDFSLFSAYANNKTFMAS---LEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSD----CD 498
            .:..:..:|...|.|.:.:.|.   :|.|.......:..|    ...|||.....:|.|    .|
Human  3171 TKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVP----NQDIPGVIALTLFEDYIYWTD 3231

  Fly   499 KKPCRLQ-------SPNFPGIYP----RNLTCYYAVRQHDVPHGKHALILVKQPKGNLVWISTQE 552
            .|...|.       :.....||.    .::..|::.||.||  .||..::......:|..::..:
Human  3232 GKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMINNGGCSHLCLLAPGK 3294

  Fly   553 T-----------AAANKMA-PPPSASDKDKKFEPRLKTWNYCDYIQENVKPKWKSTDYVTVYDGY 605
            |           ||.|:.. ...:||....|.:..:..|..||.:.:                  
Human  3295 THTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDD------------------ 3341

  Fly   606 TTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTF-TGTSSQVLPLYGFQLEVEVQFVD-- 667
                      ||.|       |..|:...||...| |.| .||....||  .|..:.|....|  
Human  3342 ----------CGDG-------SDEPDDCPEFRCQP-GRFQCGTGLCALP--AFICDGENDCGDNS 3386

  Fly   668 --IQSPTY---------SKNKKPCEFWIRGAGRGIL-------ESPKHSLAPN----STCLYHLQ 710
              :...|:         :||:|.....:|..|:...       :.|::|.:|:    .|..:.:.
Human  3387 DELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCIS 3451

  Fly   711 GLGV-------FKTFDHLSLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGV 768
            .|.|       ....|..:..::|   .|.|:        ......|..|:..:.|         
Human  3452 KLWVCDEDPDCADASDEANCDKKT---CGPHE--------FQCKNNNCIPDHWRCD--------- 3496

  Fly   769 LQTQEDCSGMLRIWDGTLRDAPVCKDLNCATETSSYNTLGHY-THNSTSVIARF-------CR-G 824
              :|.|||      |.:  |...||...|        ||..: ..|...|.:||       |. |
Human  3497 --SQNDCS------DNS--DEENCKPQTC--------TLKDFLCANGDCVSSRFWCDGDFDCADG 3543

  Fly   825 TIPRTCDRSNINETY-------------------------------ARPCTISESYVSTSD-AIT 857
            :..|.|:.|...:.:                               |.|...|..|:..|| .|:
Human  3544 SDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCIS 3608

  Fly   858 LELR-NTE------------STVLRPLDFKLKYEFIDLHQDGLPW-GGGEHDCNRKFLSSMMDRK 908
            ..|: |.|            .|..:...|:.|.:   .|...:.| ..|.|||        :|..
Human  3609 ASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNK---AHCIPIRWLCDGIHDC--------VDGS 3662

  Fly   909 DPAIFRSVRNIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVDE--DINRSFC 971
            |........||.........|..|...|....||             ..|....||  |:...|.
Human  3663 DEENCERGGNICRADEFLCNNSLCKLHFWVCDGE-------------DDCGDNSDEAPDMCVKFL 3714

  Fly   972 YGDTNVRIEIFERPY---HDSILLHRGCMCN-------SSNQSHLPVEYTSTSRDVEV-HFIAQN 1025
            ...|        ||:   ::.|.|....|||       :|::.|...:.|..:|..:. .|...|
Human  3715 CPST--------RPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN 3771

  Fly  1026 ---------MTTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGPSGTIDMTFGDVECRSRP 1076
                     ...|||....:.|..........:|:|.....|.....:.....|.||.:|
Human  3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKP 3831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 16/30 (53%)
CUB 503..646 CDD:238001 31/166 (19%)
LDLa 1203..1231 CDD:197566
LRP1BNP_061027.2 LDLa 76..109 CDD:197566
FXa_inhibition 163..193 CDD:464251
NHL 282..459 CDD:302697
NHL repeat 285..321 CDD:271320
LDL-receptor class B 1 295..337
LY 319..361 CDD:214531
NHL repeat 328..367 CDD:271320
LDL-receptor class B 2 338..381
NHL repeat 371..406 CDD:271320
LDL-receptor class B 3 382..425
NHL repeat 415..445 CDD:271320
FXa_inhibition 475..516 CDD:464251
LY 548..590 CDD:214531
LDL-receptor class B 4 568..610
LY 591..630 CDD:214531
LDL-receptor class B 5 611..656
LY 637..686 CDD:214531
LDL-receptor class B 6 657..706
LY 687..729 CDD:214531
LDL-receptor class B 7 707..750
FXa_inhibition 798..833 CDD:464251
LDLa 886..919 CDD:238060
LDLa 926..958 CDD:197566
LDLa 1006..1038 CDD:238060
LDLa 1053..1088 CDD:238060
LDLa 1097..1131 CDD:238060
LDLa 1136..1169 CDD:197566
FXa_inhibition 1176..1212 CDD:464251
YncE 1282..1506 CDD:442618
LDL-receptor class B 8 1300..1346
LY 1327..1367 CDD:214531
LDL-receptor class B 9 1347..1389
LY 1371..1414 CDD:214531
LDL-receptor class B 10 1390..1436
LDL-receptor class B 11 1437..1480
LDL-receptor class B 12 1481..1522
LDL-receptor class B 13 1618..1660
Ldl_recept_b 1618..1658 CDD:459654
LY 1641..1683 CDD:214531
LDL-receptor class B 14 1661..1704
LDL-receptor class B 15 1705..1744
Ldl_recept_b 1705..1742 CDD:459654
LY <1735..1766 CDD:214531
LDL-receptor class B 16 1745..1787
FXa_inhibition 1838..1874 CDD:464251
Vgb 1921..>2110 CDD:443399
LDL-receptor class B 17 1922..1964
LY 1947..1987 CDD:214531
LDL-receptor class B 28 1965..2007
LDL-receptor class B 19 2008..2051
LY 2033..2075 CDD:214531
LDL-receptor class B 20 2052..2095
FXa_inhibition 2147..2182 CDD:464251
LDL-receptor class B 21 2239..2280
LDL-receptor class B 22 2281..2329
LDL-receptor class B 23 2330..2374
Ldl_recept_b 2330..2372 CDD:459654
LY 2355..2397 CDD:214531
LDL-receptor class B 24 2375..2416
LDL-receptor class B 25 2417..2459
FXa_inhibition 2468..2502 CDD:464251
LDLa 2514..2543 CDD:238060
LDLa 2552..2586 CDD:238060
LDLa 2591..2625 CDD:238060
LDLa 2645..2674 CDD:238060
LDLa 2682..2716 CDD:238060
LDLa 2720..2753 CDD:238060
LDLa 2760..2793 CDD:197566
LDLa 2844..2877 CDD:197566
LDLa 2891..2925 CDD:238060 18/33 (55%)
FXa_inhibition 2937..2966 CDD:464251 2/28 (7%)
EGF_CA 2968..2998 CDD:214542 3/29 (10%)
LY 3035..3079 CDD:214531 4/43 (9%)
LDL-receptor class B 26 3055..3098 5/42 (12%)
LY 3080..3118 CDD:214531 8/41 (20%)
LDL-receptor class B 27 3099..3141 11/51 (22%)
LY 3123..3164 CDD:214531 8/63 (13%)
LDL-receptor class B 28 3142..3185 11/65 (17%)
LY 3167..3206 CDD:214531 7/38 (18%)
LDL-receptor class B 29 3186..3224 7/41 (17%)
LDL-receptor class B 30 3225..3268 7/42 (17%)
FXa_inhibition 3277..3313 CDD:464251 5/35 (14%)
LDLa 3317..3348 CDD:197566 10/65 (15%)
LDLa 3357..3391 CDD:238060 10/36 (28%)
LDLa 3396..3431 CDD:238060 5/34 (15%)
LDLa 3436..3471 CDD:238060 5/34 (15%)
LDLa 3476..3510 CDD:238060 11/60 (18%)
LDLa 3515..3549 CDD:238060 10/41 (24%)
LDLa 3553..3587 CDD:238060 0/33 (0%)
LDLa 3594..3628 CDD:238060 8/33 (24%)
LDLa 3632..3667 CDD:238060 10/45 (22%)
LDLa 3674..3706 CDD:238060 7/44 (16%)
LDLa 3721..3751 CDD:238060 6/29 (21%)
LDLa 3762..3796 CDD:238060 6/33 (18%)
EGF_CA 3844..3878 CDD:214542
LDL-receptor class B 31 3933..3980
LY <3971..>3990 CDD:214531
LDL-receptor class B 32 3981..4038
LDL-receptor class B 33 4039..4082
Ldl_recept_b 4039..4080 CDD:459654
LY 4063..4102 CDD:214531
LDL-receptor class B 34 4083..4127
EGF_CA 4250..4284 CDD:238011
Endocytosis signal. /evidence=ECO:0000255 4492..4495
Endocytosis signal. /evidence=ECO:0000255 4559..4562
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.