DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and sorl1

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_005157607.1	Gene:	sorl1 / 497306	ZFINID:	ZDB-GENE-050208-22	Length:	2213	Species:	Danio rerio

Alignment Length:	1286	Identity:	235/1286 - (18%)
Similarity:	376/1286 - (29%)	Gaps:	501/1286 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DIGQTYAL-----------------------ELHRPKQDRVPFVCVLTFT--AAGGQHGDVVQVT 298
            |.|:|:.|                       :.|.|:.|.    .:||.|  ....|:..::...
Zfish   237 DFGETWVLIQEHVKFYFWGVEPYDNPTTVFVQRHEPQGDS----SILTSTDFFQSEQNRRIILEK 297

  Fly   299 LDSFTIGRFTSYVHEGCPDGYMQIAESARTPIGG-------MWCGSSWGPV-------------- 342
            :|||.:           .|.|| .|.:.|..:|.       :|...:..|:
Zfish   298 VDSFQL-----------RDKYM-FATTTRALLGSHESQSVQLWVSYNRQPMRAAQFNTRHPITEY 350

  Fly   343 ----------------------LFYSETRSLIFTIRLNRL---ARDQSGYNFDFRIRYKVLSRDS 382
                                  |:.|:|:.|.|::.|..:   :.|.||.|  ..|||......:
Zfish   351 YIADASEDQVFVCVNHNNNVTHLYISDTQGLSFSLSLENVLYFSPDGSGSN--TLIRYFANEPFA 413

  Fly   383 SVTRYGGIK---LAEL-------------------AQWH------------------NRSSFLNQ 407
            .:.|..|::   :|.|                   ..|.                  |....|:.
Zfish   414 DLHRVEGLRGVFVATLINGSVSEDNMRSVITFDKGGTWELLQPPAADSLGGTIDCQLNSGCSLHL 478

  Fly   408 QQQQQQQQQQQQQQ-----QQGAPGIL--------------EDFTNSSVARSDR----------Y 443
            .|:..|....|.::     ::.|||::              ..:.:||.....|          :
Zfish   479 AQRWSQLLNIQLRRIPILSKESAPGLIMATGSVGKNMANKPNVYVSSSAGVRWREALAGPHFYTW 543

  Fly   444 GQDFSLFSAYA---NNKTFMASLEKSLAKDEQNYTEPKYYLGDLI--PGTYCSRIF----SDCDK 499
            |....:..|.|   ::||...|..:.....|..:::.:.|:..|:  ||.. |.||    |..|:
Zfish   544 GDHGGILMAIAQGGSSKTLKYSTNEGETWKEFQFSKQEVYVYQLLTEPGEK-STIFTIFGSYADQ 607

  Fly   500 KPCRLQSPNFPGIYPRNLTCYYAVRQHDV-----PHGKHALILVKQPKGNLVWISTQETAAANKM 559
            |...|               ...|...||     ..|.:.|......:||...:..:   ...|.
Zfish   608 KHSWL---------------IVQVNASDVLGVPCSEGDYKLWSPSDERGNGCLLGRE---MVYKR 654

  Fly   560 APPPSASDKDKKFEPRLKTWN--------YCDY---IQENVK-------PKWKSTDYV------- 599
            ..|.:.....:.|:..:...|        .|||   :.|::.       |::....|.
Zfish   655 RSPHATCFNGEDFDRPISLSNCSCTRQDYECDYGFKLSEDLSLEVCVPDPEFSGNLYAPPVPCPV 719

  Fly   600 -TVY---DGY--TTRDPIILKFCGG--------GQAVPAAVSSGPELL---VEFSTSPFGTFTGT 647
             |.|   .||  .:.|.     |.|        |:.:|..|....|.:   |..|...:...:||
Zfish   720 GTTYHRSKGYRKVSGDS-----CTGGDVEARLDGENLPCPVGESNEFILYAVRNSIHRYDLASGT 779

  Fly   648 SSQVLPLYGFQLEVEVQFVDIQSPTYSKNKKPCEFWIRGAGRGILESPKHSLAPNSTC------- 705
            ..| |||.|....|.:.|      .|.||   |.:|     ..|.......|..|.:.
Zfish   780 DQQ-LPLTGLHEAVALDF------DYEKN---CLYW-----ADISLDTIQRLCMNGSSGQEVIVK 829

  Fly   706 --LYHLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSRFKVWI--SVLKFNLDPEFGQIDETSVGAI 766
              |.:::.|    :||                |:||...|:  ...|..:....|.:..|.|.:.
Zfish   830 RDLQNVEAL----SFD----------------PISRLLYWVDAGAQKIEVSNSDGDLRRTLVNSS 874

  Fly   767 GVLQTQ-----------------EDCSGMLRIW-DGTLRDAPVCKDLNCATETSSYNTLGHYTHN 813
            .|.|.:                 :..:|:.|.| ||:                           |
Zfish   875 VVDQPRALALMPAESLMFWTDWGDRAAGVYRSWMDGS---------------------------N 912

  Fly   814 STSVIARFCRGTIPRTCDRSNINETYARPCTISESYVSTSDAI-TLELRNTESTVLR---PLDFK 874
            .:.:::...|.....|.|.|.:..|        |:|   .|.| ..:......||:.   |..:.
Zfish   913 ISCIVSEGVRWPNGITADESWLYWT--------EAY---GDRIERADFNGGSRTVIMEGLPHPYA 966

  Fly   875 LKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVR-----NIFLFGR-GGTRNLKCI 933
            :.....||:.|         |.:|.           .||::.:     :..:.|| .|..:||..
Zfish   967 IAVFKNDLYWD---------DWSRM-----------GIFKAPKSGSPDSELIVGRLTGVMDLKIF 1011

  Fly   934 YKFEAQRGERVRIKMRKVTTTNRPC-YSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGCM 997
            ||.: .||:.        ...::|| ...:.:..|:..|.....|...:....       .|.|.
Zfish  1012 YKGK-NRGQN--------ACADQPCSLLCLPQPGNQRHCVCPDGVPTSVLPSG-------ERQCQ 1060

  Fly   998 CNSSNQSH----LPVEYTSTSRDVEVHFIAQN--MTTLDDPDTVNFEG-MFEFVKAPTSCKDGRR 1055
            |.|..|.|    :..|:|.....   |..|..  ::::...|:.|..| |.:..:.||:..|...
Zfish  1061 CPSGYQLHNNTCVKTEHTCLPNQ---HRCANGKCISSIWKCDSDNDCGDMSDEQECPTTSCDPSV 1122

  Fly  1056 KFG--PSGT-IDMTF--------GD----VECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQT 1105
            :|.  .||: |.:.|        ||    ..|.|     ......:|...|...|
Zfish  1123 QFRCVASGSCIPLAFKCDHEDDCGDNSDEEHCES-----HKCGPGEFTCARGACI---------- 1172

  Fly  1106 LNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPNFALVNRSRA 1170
                   .|.|||:                     .|::..:        |::..|..:.:.:..
Zfish  1173 -------RDAWRCD---------------------GDNDCRD--------WSDEANCTVGHHTCE 1201

  Fly  1171 ISVEFLRPGNGEYSFNWMELIP-RPTLSMAEDCQ-----------------FKCAELGACVNASV 1217
            .|         .:..:....|| |......:|||                 |.|:. |.|:.||.
Zfish  1202 SS---------SFQCHTGHCIPQRWVCDGDDDCQDGSDEDPTQCGRQKCNGFLCSN-GTCLPASA 1256

  Fly  1218 WCDGVVHCPSGDDETFLQCSALMKLPAEILA---TLCLIFVLSC-----CA 1260
            .|:||..||.|.||.  .|..|.....|.:.   ..||...|.|     ||
Zfish  1257 HCNGVEDCPGGADEQ--NCGPLCAHYMEFVCRNRAQCLFQSLVCDGTRHCA 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566
		CUB	503..646	CDD:238001	31/189 (16%)
		LDLa	1203..1231	CDD:197566	13/44 (30%)
sorl1	XP_005157607.1	VPS10	130..754	CDD:214740	95/558 (17%)
		Sortilin_C	589..754	CDD:292523	35/188 (19%)
		LY	781..822	CDD:214531	15/55 (27%)
		LY	825..864	CDD:214531	9/58 (16%)
		LY	868..912	CDD:214531	9/70 (13%)
		LY	916..954	CDD:214531	9/48 (19%)
		LDLa	1079..1113	CDD:238060	6/36 (17%)
		LDLa	1118..1154	CDD:238060	8/35 (23%)
		LDLa	1159..1193	CDD:238060	9/79 (11%)
		LDLa	1242..1273	CDD:238060	14/33 (42%)
		LDLa	1282..1310	CDD:197566	7/24 (29%)
		LDLa	1327..1361	CDD:238060
		LDLa	1376..1405	CDD:238060
		LDLa	1421..1455	CDD:238060
		LDLa	1474..1509	CDD:238060
		LDLa	1522..1551	CDD:238060
		FN3	1559..>1630	CDD:238020
		FN3	1653..1743	CDD:238020
		FN3	1750..1827	CDD:238020
		FN3	1931..2007	CDD:238020
		FN3	2022..2097	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900