DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32432 and arr

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	144/771 - (18%)
Similarity:	230/771 - (29%)	Gaps:	311/771 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 KDKKFEPRLKTWNYCDYIQENVKPKWKSTDYVTVYDGYTTRDPII--LKFCGG----GQAVPAAV 626
            |..:.||:|     |..|..|.....|:|.......|...|..:|  |..|.|    .|.....:
  Fly     8 KSAEIEPQL-----CQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHM 67

  Fly   627 SSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQSPT------------------- 672
            .|...|:   ::.|...|..|.:.:|    |....::|..:|..||
  Fly    68 PSSSSLI---ASPPASAFVNTPATLL----FTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAID 125

  Fly   673 --YSKNKKPCEFWIRGAGRGILESPKHSLAPNSTCLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQ 735
              |:|| ..|  | ..:||.|:|..:    .||:.|..|           |...::|...:|:.:
  Fly   126 FYYAKN-LVC--W-TDSGREIIECAQ----TNSSALQPL-----------LRAPKQTVISTGLDK 171

  Fly   736 PLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDAPVCKDLNCATE 800
            |......|.:...:..|.|..:|:         :.|.:.....:..|  |..|.|....:..|.:
  Fly   172 PEGLAMDWYTDKIYWTDGEKNRIE---------VATLDGRYQKVLFW--TDLDQPRAVAVVPARK 225

  Fly   801 TSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESYVSTSDAITLELRNTES 865
            ...:...|.|                |: .:|::::.......|:.:.:|...:.:.::|:|
  Fly   226 LLIWTDWGEY----------------PK-IERASMDGDPLSRMTLVKEHVFWPNGLAVDLKN--- 270

  Fly   866 TVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRNIFLFGRGGTRNL 930
                    :|.|           |..|:|    .|:..|  |.|.:..|::.|          ||
  Fly   271 --------ELIY-----------WTDGKH----HFIDVM--RLDGSSRRTIVN----------NL 300

  Fly   931 KC----------IYKFEAQRGE------RVRIKMRKVTTTNRPCYSRV-DEDINRSFCYGDTNVR 978
            |.          :|..:.|||.      :.|.....:.|...|...|. |..:
  Fly   301 KYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSL------------ 353

  Fly   979 IEIFERPYHDSILLHRGCMCNSSNQSHLPVEYTST--------------------SRDVEVHFIA 1023
                 :||.|:     .|..|:.|.|||.:..|::                    :...|:.||.
  Fly   354 -----QPYEDN-----PCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISANTCANGSQEMMFIV 408

  Fly  1024 Q----NMTTLDDPD---------------TVNFEGMFEFV--------KAPTSCKDGRRKFGPSG 1061
            |    :..:||.||               .::::.:.|.:        ....:..||      :|
  Fly   409 QRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADG------TG 467

  Fly  1062 TIDMTFGDV---ECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSR 1123
            ..|....:|   :..:..||..                          |..:..|.|.|.|
  Fly   468 VTDFVTSEVRHPDGLALDWLAR--------------------------NLYWTDTVTDRIE---- 502

  Fly  1124 AVLTTSEGLTIVACPLSPDSNA-----YEFVE-------------IFSSGWNER----PNFALVN 1166
                        .|.|  |..|     ||.:|             :|.|.||||    ...:|..
  Fly   503 ------------VCRL--DGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDG 553

  Fly  1167 RSRAISV-EFLRPGNGEYSFNWMELIPRPTLSMAEDCQFKCAELGACVNASVWCDG 1221
            ..|.:.| |.|...||                :|.|.:.|         |..||||
  Fly   554 SERVVLVSENLGWPNG----------------IALDIEAK---------AIYWCDG 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566
		CUB	503..646	CDD:238001	20/83 (24%)
		LDLa	1203..1231	CDD:197566	6/19 (32%)
arr	NP_524737.2	LY	162..201	CDD:214531	8/47 (17%)
		NHL	168..503	CDD:302697	74/470 (16%)
		NHL repeat	172..237	CDD:271320	13/91 (14%)
		LY	252..293	CDD:214531	13/68 (19%)
		NHL repeat	261..298	CDD:271320	12/64 (19%)
		NHL repeat	303..339	CDD:271320	5/35 (14%)
		NHL repeat	341..419	CDD:271320	17/99 (17%)
		NHL repeat	428..476	CDD:271320	5/53 (9%)
		LY	472..511	CDD:214531	11/82 (13%)
		NHL repeat	477..503	CDD:271320	7/67 (10%)
		Ldl_recept_b	534..573	CDD:278487	14/54 (26%)
		LY	558..599	CDD:214531	13/52 (25%)
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:291342
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900