DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and LRP4

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_002325.2	Gene:	LRP4 / 4038	HGNCID:	6696	Length:	1905	Species:	Homo sapiens

Alignment Length:	609	Identity:	115/609 - (18%)
Similarity:	187/609 - (30%)	Gaps:	219/609 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDE-------PRFC-TRCNRTYYGDIGQTYA 265
            :.|..|:|.:|.|.||||:...|.||.:|||||.|||       ||.. ..|| ...|...|...
Human   307 TGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCN-VNNGGCAQKCQ 370

  Fly   266 LELHRPKQDRVPFVCVLTF--TAAGGQHGDVVQVTLDSFTIGRFTSYVHEGC--PDGYMQIAESA 326
            :     .:..|...|...:  |..|....||.:...:        .|..:||  .:|..|
Human   371 M-----VRGAVQCTCHTGYRLTEDGHTCQDVNECAEE--------GYCSQGCTNSEGAFQ----- 417

  Fly   327 RTPIGGMWCGSSW--------------GPVLFYS---ETRSLI-----FTIRLNRLARDQSGYNF 369
                  .||.:.:              .|||.::   :.|.::     :|:.||.|   ::....
Human   418 ------CWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL---ENAIAL 473

  Fly   370 DFRIRYKVLSRDSSVTRYGGIKLAELAQWHN--RSSFLNQQQQQQQQQQQQQQQQQGAPGILEDF 432
            ||..|                  .||..|.:  ....|.........::......:...|:..|:
Human   474 DFHHR------------------RELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDW 520

  Fly   433 TNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLAKD--EQNYTEPKYYLGDLIPGTYCSRIFS 495
            .:..:..:|.           ..::..:|:|:.:..|.  .||..:|:......:.||.   .::
Human   521 VHDKLYWTDS-----------GTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTI---YWT 571

  Fly   496 DCDKKPCRLQSPNFPG-----------IYPRNLTCYYAVRQH---DVPH---------GKHALIL 537
            |....| |:::.:..|           .:|..||..||.|:.   |..|         |.|...:
Human   572 DWGNTP-RIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAV 635

  Fly   538 VKQP----------KGNLVWIS--TQETAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVK 590
            :.|.          :.:|.|..  |:...:|||.........::|...|
Human   636 ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFP---------------- 684

  Fly   591 PKWKSTDYVTVYDGYTTRDPIILKFCG------------GGQAVPAAVSSGPELL---------- 633
                    :.::..:..|.|.....||            .||....|..:|...:
Human   685 --------MDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLD 741

  Fly   634 -------------VEFSTSPFGTFTGTSSQVLPLYGFQLEV---------EVQFVDIQSPTYSKN 676
                         :.|.|...      |..|:||...:..|         .|.:.|:.:.|.|:.
Human   742 KFLLFARRMDIRRISFDTEDL------SDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800

  Fly   677 KKPCEFWIRGAGRGI-----LESP 695
            |     | .|.|:.:     ||||
Human   801 K-----W-DGTGQEVVVDTSLESP 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	17/30 (57%)
		CUB	503..646	CDD:238001	31/212 (15%)
		LDLa	1203..1231	CDD:197566
LRP4	NP_002325.2	LDLa	27..66	CDD:238060
		Ldl_recept_a	70..105	CDD:278486
		LDLa	110..142	CDD:238060
		LDLa	148..182	CDD:238060
		LDLa	231..265	CDD:238060
		LDLa	270..304	CDD:238060
		LDLa	311..343	CDD:197566	17/31 (55%)
		FXa_inhibition	358..393	CDD:291342	8/40 (20%)
		EGF_CA	395..434	CDD:214542	9/57 (16%)
		NHL	<471..622	CDD:302697	30/183 (16%)
		NHL repeat	471..507	CDD:271320	7/53 (13%)
		LDL-receptor class B 1	480..522		6/41 (15%)
		LY	505..545	CDD:214531	5/50 (10%)
		NHL repeat	510..550	CDD:271320	6/50 (12%)
		LDL-receptor class B 2	523..565		7/52 (13%)
		NHL repeat	555..589	CDD:271320	7/37 (19%)
		LDL-receptor class B 3	566..609		10/46 (22%)
		LY	590..632	CDD:214531	9/41 (22%)
		NHL repeat	598..622	CDD:271320	8/23 (35%)
		LDL-receptor class B 4	610..652		6/41 (15%)
		LY	633..673	CDD:214531	7/39 (18%)
		LDL-receptor class B 5	653..693		8/63 (13%)
		FXa_inhibition	702..>729	CDD:291342	6/26 (23%)
		LY	766..806	CDD:214531	11/45 (24%)
		LDL-receptor class B 6	785..827		12/40 (30%)
		LY	808..850	CDD:214531	4/11 (36%)
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..911	CDD:278487
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LY	938..979	CDD:214531
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:291342
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		Ldl_recept_b	1179..1219	CDD:278487
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:291342
		LY	1379..1418	CDD:214531
		LDL-receptor class B 16	1397..1439
		LY	1420..1460	CDD:214531
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1523	CDD:278487
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LY	1549..1589	CDD:214531
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..>1641	CDD:291342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1659..1686
		Endocytosis signal. /evidence=ECO:0000255	1766..1769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1852..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900