DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and LRP3

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_005259002.1	Gene:	LRP3 / 4037	HGNCID:	6695	Length:	785	Species:	Homo sapiens

Alignment Length:	509	Identity:	110/509 - (21%)
Similarity:	154/509 - (30%)	Gaps:	201/509 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 TAAAAGGGGGGGGGAAPVSGSGAAGFPSSSSSISSSLGPGKPVNLQLAPGSSSTGCSLAEFSCSN 223
            |....|.|...|..:||.|..                 ||     .|.||.:        |.||.
Human   187 TVDECGDGSDEGNCSAPASEP-----------------PG-----SLCPGGT--------FPCSG 221

  Fly   224 G---RCVPLSKYCNNLNDCGDGSDE---PRF-CTRCNRTYYGDIGQTYALELHRPKQDRVPFVCV 281
            .   ||:|:.:.|:.|.||||||||   |.. |.|...::||.                  |...
Human   222 ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGS------------------FASP 268

  Fly   282 LTFTAAGGQ---HGDVVQVTLDS--------FTIGRFTSYVHEGCPDGYMQIAESARTPIGGMWC 335
            ..|.||.|.   |...:..|.||        ..:|.          |.|:|:.|.    :|..
Human   269 DLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGY----------DDYVQVYEG----LGER-- 317

  Fly   336 GSSWGPVLFY-SETRSLIFTIRLNRL-----ARDQS---GYNFDFRIRYKVL--------SRDSS 383
            |......|.| |..|.:.......||     ||.:|   |:|..::::...|        |.||.
Human   318 GDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSD 382

  Fly   384 VTRYGGIKLAELAQ-----WHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRY 443
            ....|........|     ||..|.                :.:||.|          ....|:|
Human   383 GGSLGDQGCFSEPQRCDGWWHCASG----------------RDEQGCP----------ACPPDQY 421

  Fly   444 GQDFSLFSAY-----ANNKTFMASLEKSL--AKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKP 501
            ..:......|     .||       :||.  ..||:|....:       |||:      .|....
Human   422 PCEGGSGLCYTPADRCNN-------QKSCPDGADEKNCFSCQ-------PGTF------HCGTNL 466

  Fly   502 CRLQSPNFPGIYPRNLTCYYAVRQHDVPHG--KHALILVKQPK-------GNLVW---------- 547
            |..::....|             |.|...|  :|..:.....|       |:||.
Human   467 CIFETWRCDG-------------QEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGC 518

  Fly   548 ------ISTQE--TAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVKPKW 593
                  :.|||  :.||....|||:||   :.||.:: |....::::....|.:
Human   519 AFKLYSLRTQEYRSRAAQSCRPPPTAS---RAFETQM-TRLEAEFVRREAPPSY 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	14/33 (42%)
		CUB	503..646	CDD:238001	23/118 (19%)
		LDLa	1203..1231	CDD:197566
LRP3	XP_005259002.1	CUB	43..156	CDD:238001
		LDLa	166..200	CDD:238060	4/12 (33%)
		LDLa	212..249	CDD:238060	18/44 (41%)
		CUB	254..364	CDD:238001	31/143 (22%)
		LDLa	416..452	CDD:238060	9/42 (21%)
		LDLa	455..489	CDD:238060	10/59 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900