Protein Alignment CG32432 and LRP1

DIOPT Version :9

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: XP_016874792.1
• Gene: LRP1 / 4035
• HGNCID: 6692
• Length: 4561
• Species: Homo sapiens
• Alignment Length: 1559
• Identity: 282/1559 - (18%)
• Similarity: 426/1559 - (27%)
• Gaps: 658/1559 - (42%)

  Fly   211 STGCSLAEFSCSNGR--CVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYG--------------- 258
            |..|......|:|..  |:|..|.|:..:||||||||...|.:|:....|
Human  1159 SLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVC 1223

  Fly   259 ------DIG--------QTYA-------------------------------------------- 265
                  ::|        |:|.
Human  1224 SCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFI 1288

  Fly   266 ----------LELHRPKQDRVPFVCVLTFTAAGGQH--------GDVVQ------VTLDSFTIGR 306
                      ::||  |.|....|..|..|.|...|        .|||:      ..||:..:..
Human  1289 IFSNRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTS 1351

  Fly   307 FTSYVHEG--CPDG------------------YMQIAE---SART----------------PIGG 332
            |...:..|  .|:|                  .:::|:   :.||                |..|
Human  1352 FEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDG 1416

  Fly   333 MWCGSSW-------------------------------GPVLFYSETRSLIFTIRLNRL--AR-D 363
            :...:.|                               |..:.|.|.|.|....|.:.:  || |
Human  1417 ILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYD 1481

  Fly   364 QSGYNFDFRIRYKVLSRDSSVTRYGG---------IKLAELAQW--HNRSSFLNQQQQQQQQQQQ 417
            .||:....| .::.||...:||.|||         ..||:..:|  ||.:.......|....|..
Human  1482 GSGHMEVLR-GHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVY 1545

  Fly   418 QQQQQQGAPGILE--------------DFTNSSVA----------RSDRYGQDFSLFSAYAN--- 455
            ...:|..||...|              :: |.:|:          :.:....:|..|..||.
Human  1546 HPSRQPMAPNPCEANGGQGPCSHLCLINY-NRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQME 1609

  Fly   456 ------NKTFMASLEKSLAKDEQNYT-------EPKYYLGDL---------IPGTYCSRIFSDCD 498
                  :..:...:......|..|.|       |.:.|..|:         |.||....:.|
Human  1610 IRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVS--- 1671

  Fly   499 KKPCRLQSPNFPGI----YPRNL--TCY------------------YAVRQHDVPHGKHALILVK 539
                 ...||..|:    ..|||  |.|                  ..|:..:.|||     ||.
Human  1672 -----ADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHG-----LVV 1726

  Fly   540 QP-KGNLVWISTQETAAANKMAPPPSASDKDKKFE------------PRLK---------TWNYC 582
            .| :|.|.|......:.||.     ..|::...|.            |..|         |.|.|
Human  1727 HPLRGKLYWTDGDNISMANM-----DGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRC 1786

  Fly   583 -------DYIQENVKPKWKSTDYVTVYDGYTTRDPIILKF--C----GGGQAVPAAVSSGPELLV 634
                   :.|........|:|....:.|.....|.:..|.  |    |.|..|   :.:...|::
Human  1787 NLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVV---LRNSTTLVM 1848

  Fly   635 EF------------STSPFGTFTGTSSQV-LP----------LYGFQLEVEVQFVDIQSPTYSKN 676
            ..            .|:|.....|..||: ||          ..|:.|.              ..
Human  1849 HMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLR--------------SG 1899

  Fly   677 KKPCE----FWIRGAGRGILESPKHSLAPN--STCLYHLQGLGVFKTFDH---------LSLSRR 726
            ::.||    |.:.....||...|   |.||  |..|..:.|..:....|.         :.:...
Human  1900 QQACEGVGSFLLYSVHEGIRGIP---LDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS 1961

  Fly   727 TSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAI--GVLQTQE--DCSGMLRIWDGTLR 787
            |.|::      .|.:.|...:..|   ..|:::..:|..|  .:..|.:  |...:.|: :|:.|
Human  1962 TISRA------KRDQTWREDVVTN---GIGRVEGIAVDWIAGNIYWTDQGFDVIEVARL-NGSFR 2016

  Fly   788 DAPVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESY--- 849
            ...:.:.|:.....:.:...|:..........|..|..:..|.....:|.:.:.|..||..|
Human  2017 YVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDG 2081

  Fly   850 --------VSTSDAITLELRNTESTVLRPLDFKLKYEF-IDLHQDGLPWGGGEHDCNRKFLSSMM 905
                    ....:.|.||.......||...:..:   | :.:.:|.:.|....| .|........
Human  2082 KLYWCDARTDKIERIDLETGENREVVLSSNNMDM---FSVSVFEDFIYWSDRTH-ANGSIKRGSK 2142

  Fly   906 DR---------------KDPAIFRSVR----NIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKV 951
            |.               ||..:|...|    |:.....||.:.| |:|:...||.......|  :
Human  2143 DNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQL-CLYRGRGQRACACAHGM--L 2204

  Fly   952 TTTNRPC--------YSRVDEDINRSFCYGD---TNVRIEIFERPYHDSILLHRGCMCNSSNQSH 1005
            ......|        ||  :..|.:|....|   .|..::.||.|.|            ..|...
Human  2205 AEDGASCREYAGYLLYS--ERTILKSIHLSDERNLNAPVQPFEDPEH------------MKNVIA 2255

  Fly  1006 LPVEY-TSTSRDV-------EVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGPSGT 1062
            |..:| ..||...       ::||  .|:..::|                    ||.|:.    |
Human  2256 LAFDYRAGTSPGTPNRIFFSDIHF--GNIQQIND--------------------DGSRRI----T 2294

  Fly  1063 IDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSRAVLT 1127
            |....|.||                        .|:.|....||..|...|.|....|..:....
Human  2295 IVENVGSVE------------------------GLAYHRGWDTLYWTSYTTSTITRHTVDQTRPG 2335

  Fly  1128 TSEGLTIVACPLSPDSNAYEFV------EIFSSGWNER------------------------PN- 1161
            ..|..|::.  :|.|.:...||      .:|.:.|||:                        ||
Human  2336 AFERETVIT--MSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNG 2398

  Fly  1162 FALVNRSR------------------------AISVEFLRPGN----GEYSF--NW--------- 1187
            .|:.:|:.                        .:..|.:.|..    ||:.|  :|
Human  2399 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRAN 2463

  Fly  1188 ------MELI-------PRPTLSMAED---------------CQ--------------------- 1203
                  |:|:       |...:::|.|               ||
Human  2464 KHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL 2528

  Fly  1204 ------------------FKCAELGACVNASVWCDGVVHCPSGDDE------------TFLQCS 1237
                              |:||. |.|:|.|:.||||.||....||            ||.|||
Human  2529 QDDLTCRAVNSSCRAQDEFECAN-GECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS 2591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	13/32 (41%)
		CUB	503..646	CDD:238001	40/213 (19%)
		LDLa	1203..1231	CDD:197566	14/66 (21%)
LRP1	XP_016874792.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900