Protein Alignment CG32432 and LDLR

DIOPT Version :10

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_000518.1
• Gene: LDLR / 3949
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 87/438 - (19%)
• Similarity: 150/438 - (34%)
• Gaps: 129/438 - (29%)

  Fly   201 VNLQLAPGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYA 265
            ||:.|..|.:       :|.|.:|.|:.|.|.||...||.|.||||          ..:.|....
Human   271 VNVTLCEGPN-------KFKCHSGECITLDKVCNMARDCRDWSDEP----------IKECGTNEC 318

  Fly   266 LE-----LHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAES 325
            |:     .|.....::.:.|:                                 ||||:..:|:.
Human   319 LDNNGGCSHVCNDLKIGYECL---------------------------------CPDGFQLVAQR 350

  Fly   326 ARTPI-----------------GGMWCGSSWGPVLFYSETRS-----------LIFTIR--LNRL 360
            ....|                 ||..|....|   |..:..:           |.||.|  :.::
Human   351 RCEDIDECQDPDTCSQLCVNLEGGYKCQCEEG---FQLDPHTKACKAVGSIAYLFFTNRHEVRKM 412

  Fly   361 ARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGA 425
            ..|:|.|.........|::.|:.|.. ..|..::|:|....|:.|::............:..|..
Human   413 TLDRSEYTSLIPNLRNVVALDTEVAS-NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAP 476

  Fly   426 PGILEDFTNSSVARSDRYGQDFSLFS-AYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTY 489
            .|:..|:.:|::     |..|..|.: :.|:.|   ....|:|.:  :|.::|:..:.|.:.|
Human   477 DGLAVDWIHSNI-----YWTDSVLGTVSVADTK---GVKRKTLFR--ENGSKPRAIVVDPVHG-- 529

  Fly   490 CSRIFSDCDKKPCRLQSPNFPGI-----------YPRNLTC-YYAVRQHDVPHGKHALILVKQPK 542
             ...::|.. .|.:::.....|:           :|..:|. ..:.|.:.|....|::..:....
Human   530 -FMYWTDWG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG 592

  Fly   543 GNLVWISTQETAAANKMAPPPS-ASDKDKKFEPRLKTWNYCDYIQENV 589
            ||...|...|    .::|.|.| |..:||.|      |.  |.|.|.:
Human   593 GNRKTILEDE----KRLAHPFSLAVFEDKVF------WT--DIINEAI 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/30 (40%)
		CUB	503..646	CDD:238001	21/100 (21%)
		LDLa	1203..1231	CDD:197566
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515	146..233
		Ldl_recept_a	147..179	CDD:395011
		Ldl_recept_a	195..231	CDD:395011
		Ldl_recept_a	235..270	CDD:395011
		Ldl_recept_a	278..308	CDD:395011	13/36 (36%)
		FXa_inhibition	318..>346	CDD:464251	7/60 (12%)
		EGF_CA	354..388	CDD:214542	6/36 (17%)
		LDL-receptor class B 1	397..438		10/40 (25%)
		LY	419..457	CDD:214531	8/38 (21%)
		LDL-receptor class B 2	439..485		8/45 (18%)
		Ldl_recept_b	439..483	CDD:459654	7/43 (16%)
		LDL-receptor class B 3	486..528		11/51 (22%)
		Ldl_recept_b	487..526	CDD:459654	9/48 (19%)
		LDL-receptor class B 4	529..572		6/46 (13%)
		Ldl_recept_b	529..569	CDD:459654	6/43 (14%)
		LY	553..595	CDD:214531	6/41 (15%)
		LDL-receptor class B 5	573..615		11/45 (24%)
		LDL-receptor class B 6	616..658		7/21 (33%)
		Ldl_recept_b	616..656	CDD:459654	7/21 (33%)
		FXa_inhibition	671..711	CDD:464251
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269|PubMed:22509010	823..828