DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32432 and CG6739

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	175/944 - (18%)
Similarity:	278/944 - (29%)	Gaps:	371/944 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 QQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTF---MASLEKSLAK-DEQNYTE 476
            |......:|:|....|:|.:|       |.     |.::..:.:   |....::||: ..:.|..
  Fly    36 QTIDDDNEGSPKDHSDYTRAS-------GD-----SCWSKTQKYHIGMLGSPETLAELQVRRYKY 88

  Fly   477 P---KYYLGDLIPGTYCSRIFSDCDKKP------------CRLQSPNFPGIYPRNLTCY-----Y 521
            |   .|||...:          :..:||            ||.:...:|.|:..::..:     |
  Fly    89 PLTANYYLNSKL----------ERPEKPTPWMLLGYARSVCRWKYLRWPIIFVASVLLFFGLITY 143

  Fly   522 AVRQHDVPHGK--------HALILVKQPKGNLVWISTQETAAANKMAPPPSA-----SDKDKKFE 573
            .:..|||...:        .|.:.......|.||  .:||.::.:.:|..:.     .|.|:..|
  Fly   144 CLWLHDVSVARAKFLQRRYEATLTSTSSSSNEVW--DEETTSSTERSPQETTRLEDMDDSDESTE 206

  Fly   574 -PRLKTWNYCDYIQENVKPKWKSTDYVTVYDGYTTRDPII----LKFCGGGQ---AVPAAVSSGP 630
             |.:.       ..::..|:....|....||     |.::    ::|..|.|   .||.......
  Fly   207 LPEIA-------FGDDGDPEAGGEDGDGDYD-----DTLLPADSIRFTSGHQNSFGVPIEQDKRM 259

  Fly   631 -ELLVEFSTSPFGTFTG---TSSQVLPLYGFQLEVEVQFVDIQSPTYSKNKKPCEFWIRGAGRGI 691
             :||.|....|..|..|   |.::|.|..              .|..|.:.:|.|..       .
  Fly   260 LQLLKELLHKPQATPAGNEPTLTRVSPTL--------------PPPLSASGRPTEAM-------A 303

  Fly   692 LESPKHSLAPNSTC----LYHLQG-LGVFKTFDHLSLSRRTSSQSGMHQPLSRFKVWISVLKF-- 749
            |.:|.   ..||.|    |...|| |....||:....:.|.:.....:..|.|....:...:|
  Fly   304 LTTPS---TTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRDAVSMAAYDSLIRANCSVRAAEFIC 365

  Fly   750 -NLDPE-----FGQIDETSVGAIGVLQTQEDCSGMLRIWD----GTLRDAPVCKDLNCATETSSY 804
             .|:||     .||:.........:|   |.||  :.|::    |.|.|..:..|
  Fly   366 GALEPECRPLHIGQLPPCRRICKAIL---EACS--IPIYNSDVLGELFDCNLYPD---------- 415

  Fly   805 NTLGHYTHNSTSVIAR--FCRGT---------IPRT--CDRSNINETYARPCTISESYVSTSDAI 856
               .|.:|.......|  :|.|.         ||:.  ||:       .:.|...|.
  Fly   416 ---AHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDK-------IKDCQGGED-------- 462

  Fly   857 TLELRNTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRNIFL 921
                .:.:..|..|.:|:.:
  Fly   463 ----EDEQCLVCEPDEFRCR--------------------------------------------- 478

  Fly   922 FGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPY 986
                  .|.||:.       |:.|...      |..|....||.....:..||.        .|:
  Fly   479 ------SNEKCLV-------EKYRCDQ------NIDCMDGSDEQDCDEYGSGDL--------APF 516

  Fly   987 HDSILLHRGCMCNSSNQSHLPVEYTSTSRDVEVHFIAQN-----------MTTLDDPDTVNFEGM 1040
            .:|.|            :..|..:|..|      |::.|           .||.:|..|   |..
  Fly   517 DESEL------------NAFPRVFTYAS------FLSPNETNDKVYTYITATTDEDAGT---ETK 560

  Fly  1041 FEF--VKAP-----TSCKDGRRKFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLS 1098
            |:.  |.||     :|.::|..  ||.|.::  |.|    |:..::...:..||.|
  Fly   561 FQIHQVAAPAPPVNSSAEEGAG--GPKGFVN--FRD----SKEIMMTSDSETKFKY--------- 608

  Fly  1099 KHNPTQTLNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPNFA 1163
                :|..|.|.|:..                    |:.|.:|.:.....:          |:.|
  Fly   609 ----SQRANRTSVKFS--------------------VSAPTTPAARTSSAI----------PSSA 639

  Fly  1164 LV-NRSR----------------------AISVEFLRPGNGEYSFNWMELIPRPTLSMAEDC--- 1202
            || .|.|                      :|:...|.|.|...|    |..|...::....|
  Fly   640 LVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATS----EPNPYEVVTSLGGCPPQ 700

  Fly  1203 QFKCAELGACVNASVWCDGVVHCPSGDDETFLQC 1236
            :.:|.. |.|:..|..||..:.||...||  |.|
  Fly   701 ELRCVS-GKCITVSQLCDKQIDCPDAADE--LMC 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566
		CUB	503..646	CDD:238001	33/169 (20%)
		LDLa	1203..1231	CDD:197566	8/27 (30%)
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	27/130 (21%)
		LDLa	432..464	CDD:238060	8/50 (16%)
		LDLa	470..505	CDD:238060	11/98 (11%)
		LDLa	697..731	CDD:238060	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900