Protein Alignment CG32432 and LRP12

DIOPT Version :10

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_038465.1
• Gene: LRP12 / 29967
• HGNCID: 31708
• Length: 859
• Species: Homo sapiens
• Alignment Length: 988
• Identity: 188/988 - (19%)
• Similarity: 296/988 - (29%)
• Gaps: 350/988 - (35%)

  Fly   449 LFSAYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQ-------S 506
            |...|.|.         :||:..:|              .:.|.:.:.|.:.|.:::       |
Human    22 LAGVYGNG---------ALAEHSEN--------------VHISGVSTACGETPEQIRAPSGIITS 63

  Fly   507 PNFPGIYPRNLTCYYAVRQH------------DVPHGKHALILVKQPKGNLVWISTQET------ 553
            |.:|..||..:.|.:.:|.:            |:...:..         ||.|: |.||
Human    64 PGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC---------NLDWL-TIETYKNIES 118

  Fly   554 -AAANKMAPPPSASDKDK---KFEPRLKTWNYCDYIQENVKPKWKSTDYVTVYDGYTTRDPIIL- 613
             .|.....|||..|.:|.   :|           :..:|:..|    .:...|....:.:|...
Human   119 YRACGSTIPPPYISSQDHIWIRF-----------HSDDNISRK----GFRLAYFSGKSEEPNCAC 168

  Fly   614 -KF-CGGGQAVPAA----------VSSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQF- 665
             :| ||.|:.:|.|          .||..|:..:.:..|      |::...|....|.:...:|
Human   169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPP------TAAAFQPCAYNQFQCLSRFT 227

  Fly   666 ------------------------VDIQSPTYSKNKKPCEFWIRGAGRGILESPKHS--LAPNST 704
                                    :|...||       |..|:: ...|...||.:.  ..|.|.
Human   228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPT-------CGQWLK-YFYGTFNSPNYPDFYPPGSN 284

  Fly   705 CL-----------------YHLQGLG---VFKTFD------HLSLSRRTSSQSGMHQPLS----- 738
            |.                 :.|.|.|   ..|.:|      |..|...|:..|  |.||:
Human   285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDS--HAPLTVVSSS 347

  Fly   739 -RFKVWISVLKFNLDPEFG---QIDETSV-------GAIGVLQTQEDCSGMLRIWDGTLRDAPVC 792
             :.:|.....|.|....|.   |:|...:       |..|....|:.|.|.....:|  ||...|
Human   348 GQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG--RDETNC 410

  Fly   793 -----KDLNCATETSSY------NTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTIS 846
                 ::..|:.....|      |...|..:.|......||:   |......|      ..| :.
Human   411 TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQ---PGNFHCKN------NRC-VF 465

  Fly   847 ESYVSTSDAITLELRNTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDC-----NRKFLSSMMD 906
            ||:|..|                              ||....|..|.:|     .|...::::.
Human   466 ESWVCDS------------------------------QDDCGDGSDEENCPVIVPTRVITAAVIG 500

  Fly   907 RKDPAIFRSVRNIFLFGRGGTRNLKCIYKFEAQRGER--VRIKMRKVTTTNRPCYSRV------- 962
            .....:      :.:...|.|..|..:..||.:..|.  .|::...:.....|.|.::
Human   501 SLICGL------LLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIP 559

  Fly   963 -DEDI-----NRSFC-----------YGDTNVRI-------EIFERPYHDSILLHRGCMCNSSNQ 1003
             .||.     |::..           .|.|:||:       .|:.|.::.:...|.|.:...|..
Human   560 PVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSAD 624

  Fly  1004 SHLPVEYTSTSRDVEVHFIAQNMTTL--DDPDTVN----FEGMFEFVKAPTSCKDGRRKFGPSGT 1062
            ....|...||||:.|.:...:::.::  ||.||.|    ..|....|.||..     :|..|:..
Human   625 GDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLP-----QKVPPTTA 684

  Fly  1063 IDMTFGDVECRSRPWLI----EPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSR 1123
            ::.|.|  .|.|.....    ...||.....|...::..::|..|..|:
Human   685 VEATVG--ACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALS---------------- 731

  Fly  1124 AVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPNFALVN----RSRAISVEFLRP---GNG 1181
               ..::||..|...|...|         |...|:.|...|.|    |.....||.|.|   |:.
Human   732 ---RMTQGLRWVRFTLGRSS---------SLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSS 784

  Fly  1182 EYSFNWMELIPRPTLSMAEDCQFKCAELGACVNASVW-------CD--GVVH-------C----- 1225
            ::..|...   ||.|.:|.|......:.....|..|.       |:  |:||       |
Human   785 DFDVNDCS---RPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTL 846

  Fly  1226 --PSGDDETFLQC 1236
              .:.|||..|.|
Human   847 KNETSDDEALLLC 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566
		CUB	503..646	CDD:238001	35/184 (19%)
		LDLa	1203..1231	CDD:197566	8/50 (16%)
LRP12	NP_038465.1	CUB	47..158	CDD:238001	26/135 (19%)
		LDLa	166..200	CDD:238060	9/33 (27%)
		LDLa	215..254	CDD:238060	2/38 (5%)
		CUB	267..371	CDD:238001	22/105 (21%)
		LDLa	413..448	CDD:238060	5/34 (15%)
		LDLa	451..485	CDD:238060	12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..678		15/59 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	693..723		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..770		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..823		3/21 (14%)