DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Sorl1

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_035566.2 Gene:Sorl1 / 20660 MGIID:1202296 Length:2215 Species:Mus musculus


Alignment Length:1265 Identity:241/1265 - (19%)
Similarity:393/1265 - (31%) Gaps:461/1265 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 PGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPR---FCTRCNRTYYGDIGQTYALEL 268
            |.|....|:  .|.|.||.|:|.||:|:.|.||.|||||..   ||||.                
Mouse  1232 PVSCEKKCN--GFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRF---------------- 1278

  Fly   269 HRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEG---CPDGYMQIAESARTPI 330
                   :.|||...            |..|       |.|.|.:|   |.||..:.|..|    
Mouse  1279 -------MDFVCKNR------------QQCL-------FHSMVCDGIVQCRDGSDEDAAFA---- 1313

  Fly   331 GGMWCGSSWGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAEL 395
                 |.|..|. |:.|.              |:.|:                            
Mouse  1314 -----GCSQDPE-FHKEC--------------DEFGF---------------------------- 1330

  Fly   396 AQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQ--DFSLFSAYANNKT 458
                                    |.|.|.       ..|.:.:.|....  |:|          
Mouse  1331 ------------------------QCQNGV-------CISLIWKCDGMDDCGDYS---------- 1354

  Fly   459 FMASLEKSLAKDEQNYTEP-------KYYL-----GDLIPGTY-CSRIFSDC----DKKPCRLQS 506
                       ||.|...|       :|:.     |..||..: |.| .:||    |:|.|. .|
Mouse  1355 -----------DEANCENPTEAPNCSRYFQFHCENGHCIPNRWKCDR-ENDCGDWSDEKDCG-DS 1406

  Fly   507 PNFPGIYPRNLTCYYAVRQHDVPHGKH----ALILVKQPKGNLVWISTQETAAANKMAPPPSASD 567
            ...|...|...||        :|:..|    |.::     |..|....::.|..:.....||.::
Mouse  1407 HVLPSPTPGPSTC--------LPNYFHCSSGACVM-----GTWVCDGYRDCADGSDEEACPSLAN 1458

  Fly   568 KDKKFEPRLKTWNYCDYIQ------ENVKPKWKSTDYVTVYDGYTTRDPIILKFCGGGQAVPAAV 626
            ......|  ..:..||..:      :...|.||..      ||:        :.|..||.     
Mouse  1459 STAASTP--TQFGQCDRFEFECHQPKKCIPNWKRC------DGH--------QDCQDGQD----- 1502

  Fly   627 SSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQLE-----VEVQ-----FVDIQSPTYSKNKKPC- 680
                    |.:.....|.|.||.:      |:.|     :.:.     |:|...   ..::|.| 
Mouse  1503 --------EANCPTHSTLTCTSRE------FKCEDGEACIVLSERCDGFLDCSD---ESDEKACS 1550

  Fly   681 ---------------EF-------WIRGAGRGILESPKHSLAPNSTCLYHLQ----GLGVFKTFD 719
                           :|       |:|         ||.  .|:::|:|::.    |..::||.:
Mouse  1551 DELTVYKVQNLQWTADFSGDVTLTWMR---------PKK--MPSASCVYNVYYRVVGESIWKTLE 1604

  Fly   720 HLSLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDG 784
              :.|.:||:...:.:|.:.::|.:.|...|      ::..|:  ....|:|.|.          
Mouse  1605 --THSNKTSTVLKVLKPDTTYQVKVQVHCLN------KVHNTN--DFVTLRTPEG---------- 1649

  Fly   785 TLRDAPVCKDLNCATETSSYNTLGH-----YTHN-STSVIARFCR-GTIPRTCDRSNINETYARP 842
             |.|||....|:..:|.... .|||     :||. ....|..:.| |:......|:..|.|..:.
Mouse  1650 -LPDAPRNLQLSLNSEEEGV-ILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKN 1712

  Fly   843 CTISESYV--------------STSDAIT------LELRN--TESTVLRPLDFKLKYEFIDLHQD 885
            ..::..|.              |.|.:||      ::..|  .:|.....|.|.|..:. |:..:
Mouse  1713 LLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPNIHIDSYDENSLSFTLTMDG-DIKVN 1776

  Fly   886 G----LPWGGGEHDCNRKFLSSMMDRKDPAIFRSVRN--------IFLFGRGGTRNLKCIYKFEA 938
            |    |.|....|...:|.||.   |...|:...|.|        |..:.:....:....::...
Mouse  1777 GYVVNLFWSFDAHKQEKKTLSF---RGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHIL 1838

  Fly   939 QRGE---RVRIKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGCMCNS 1000
            .||.   ...:|.:.:..|...|.....:::.....|..:  .::::..|...:..||...:..|
Mouse  1839 TRGSSPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATS--FLDLYRNPKSVTTSLHNKTVIVS 1901

  Fly  1001 SNQSHL-----PVEYTSTSRDVEV------------HFIAQNM----------TTLDDPDTVNFE 1038
            .::.:|     .:.|...|.|..|            |..|.::          :..|.||    :
Mouse  1902 KDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVHIGKTSALIKWESPYDSPD----Q 1962

  Fly  1039 GMFEFVKAPTSCKDGRRKFGPSGTIDMTFGDVECRSRPWLIEPS-----NGNKFLYVRLKAIFLS 1098
            .:|..:    :.||..||         |....:.|||...:|.|     .|.|: ::.::...:|
Mouse  1963 DLFYAI----AVKDLIRK---------TDRSYKVRSRNSTVEYSLSKLEPGGKY-HIIVQLGNMS 2013

  Fly  1099 KHNPTQTLNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPNFA 1163
            |.:..:....:....|..:..|::..||...:.|.:.                 ...:||...:.
Mouse  2014 KDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALK-----------------EKQFNETRGYE 2061

  Fly  1164 LVNRSRAISV---------EFLRPGNGEYSFNWMELIPRPTLSMAEDCQFK---CAELGACVNAS 1216
            :.....|:::         .|.:..|.:...|:       |.::...|.|.   |.|....:...
Mouse  2062 IHMSDSAVNLTAYLGNTTDNFFKVSNLKMGHNY-------TFTVQARCLFGSQICGEPAVLLYDE 2119

  Fly  1217 VWCDGVVHCPSGDDETFLQCSALMKLPAEILATLCLIFVLSCCAFAAFAYKKIKRKLRGS----- 1276
            :        .||.|...:|.:....:.|.::..|.|| :||.....|..|.| .|:|:.|     
Mouse  2120 L--------SSGADAAVIQAARSTDVAAVVVPILFLI-LLSLGVGFAILYTK-HRRLQSSFSAFA 2174

  Fly  1277 -SVLQTRLKS--LSSMDTAVLDEKEKKPVV 1303
             |...:||.|  .||.|....|: |..|::
Mouse  2175 NSHYSSRLGSAIFSSGDDLGEDD-EDAPMI 2203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 16/30 (53%)
CUB 503..646 CDD:238001 26/152 (17%)
LDLa 1203..1231 CDD:197566 5/30 (17%)
Sorl1NP_035566.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..84
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2 844..887
LY 868..910 CDD:214531
LDL-receptor class B 3 888..932
Ldl_recept_b 890..929 CDD:459654
LY 913..953 CDD:214531
LDL-receptor class B 4 933..972
LY 953..987 CDD:214531
LDL-receptor class B 5 973..1013
LDLa 1078..1112 CDD:238060
LDLa 1117..1153 CDD:238060
Ldl_recept_a 1157..1192 CDD:395011
Ldl_recept_a 1198..1230 CDD:395011
LDLa 1240..1271 CDD:238060 17/32 (53%)
LDLa 1281..1308 CDD:197566 12/45 (27%)
LDLa 1325..1359 CDD:238060 11/127 (9%)
LDLa 1373..1403 CDD:238060 9/30 (30%)
LDLa 1419..1453 CDD:238060 7/46 (15%)
LDLa 1471..1506 CDD:238060 11/61 (18%)
LDLa 1514..1549 CDD:238060 7/43 (16%)
FN3 1557..1630 CDD:238020 16/85 (19%)
FN3 1651..1742 CDD:238020 20/91 (22%)
FN3 1690..>2100 CDD:442628 75/457 (16%)
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165 1/3 (33%)
Endocytosis signal. /evidence=ECO:0000255 2173..2178 1/4 (25%)
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215 4/14 (29%)
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215 0/2 (0%)
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213
Blue background indicates that the domain is not in the aligned region.

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