DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and EGF

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_016863334.1	Gene:	EGF / 1950	HGNCID:	3229	Length:	1223	Species:	Homo sapiens

Alignment Length:	420	Identity:	78/420 - (18%)
Similarity:	127/420 - (30%)	Gaps:	185/420 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SSSSISSSLGPGKPVNLQLAP--------GSSSTGCSLAEFSCSNGRCVPLSKY---CNNLNDCG 240
            |...:.:|.||     |...|        |.:.:|||..:....:..|||||..   |    ||.
Human   417 SHDCVLTSEGP-----LCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWEC----DCF 472

  Fly   241 DGSD---EPRFCT-------------------RCNRTYYG-----DIGQTYALELHRPKQDRVPF 278
            .|.|   :.:.|.                   ..:.|.||     .:|..|||: |.|.::::.|
Human   473 PGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALD-HDPVENKIYF 536

  Fly   279 VCVLTFTAA---------GGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAESARTPIGGMW 334
                ..||.         |.|...:::..:|              .|:|           :...|
Human   537 ----AHTALKWIERANMDGSQRERLIEEGVD--------------VPEG-----------LAVDW 572

  Fly   335 CGSSWGPVLFY--SETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQ 397
            .|..     ||  ...:|||....||..             |.|::::: ::::..||.:..:|:
Human   573 IGRR-----FYWTDRGKSLIGRSDLNGK-------------RSKIITKE-NISQPRGIAVHPMAK 618

  Fly   398 ---WHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQ-----DFSLFSAYA 454
               |.:..  :|.:.:...               |:......:|.||....     ||
Human   619 RLFWTDTG--INPRIESSS---------------LQGLGRLVIASSDLIWPSGITIDF------- 659

  Fly   455 NNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIYPRNLTC 519
                               .|:..|:                ||.|...::..|..|...|.||
Human   660 -------------------LTDKLYW----------------CDAKQSVIEMANLDGSKRRRLT- 688

  Fly   520 YYAVRQHDVPHGKHALILVKQPKGNLVWIS 549
                 |:||.| ..|:.:.:    :.||.|
Human   689 -----QNDVGH-PFAVAVFE----DYVWFS 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/36 (33%)
		CUB	503..646	CDD:238001	13/47 (28%)
		LDLa	1203..1231	CDD:197566
EGF	XP_016863334.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900