DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and lrp-1

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_001379135.1 Gene:lrp-1 / 172520 WormBaseID:WBGene00003071 Length:4753 Species:Caenorhabditis elegans


Alignment Length:1280 Identity:246/1280 - (19%)
Similarity:379/1280 - (29%) Gaps:448/1280 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFC--TRCNRTYYGDIGQTYALELHR------ 270
            |:..||.|.|.||.|....|:..:||||.|||.. |  .||....:...|..:.::..:      
 Worm   223 CTANEFQCKNKRCQPRKFRCDYYDDCGDNSDEDE-CGEYRCPPGKWNCPGTGHCIDQLKLCDGSK 286

  Fly   271 ------PKQDRVPFVCVLTFTAAG---GQHGDVVQVT------LDSFTIGRFTSYVHEGCPD--- 317
                  .:|.....:|......||   ..||.  :.|      ||.    ||    |..|.|   
 Worm   287 DCADGADEQQCSQNLCPSLGCQAGCHPSPHGG--ECTCPSGYKLDD----RF----HRTCSDINE 341

  Fly   318 ----GYM-QIAESARTPIGGMWCG---------SSWGP-------------------VLFYSETR 349
                ||. |:..:.|.   |..|.         ...||                   .||.:...
 Worm   342 CAEFGYCDQLCANHRP---GFTCSCLGDCFTLQMEHGPGKDNLTMRGYCVSNNADKMKLFVARRE 403

  Fly   350 SLIFTIRLN---------RLARDQSGYNFDF-----------RIRYKVLSRD----SSVTRYGGI 390
            .|   .|||         :||..:..|..||           |:.:...|.|    ..:::...:
 Worm   404 GL---YRLNPKNPDEEVKKLASGEFIYGIDFDYGDRKIFWTDRLAHSAFSADVDDEGEISQIKKL 465

  Fly   391 KLAEL-------AQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTN--SSVARSDRYGQD 446
            .|..|       ..|...:.::.:...::........:::..  :|.|...  ..:|.....|:.
 Worm   466 SLKSLVYPRCLAVDWITNTLYIIESGSRRIDVSSYDGERRTV--LLADGLTLPLDIALDPLRGEM 528

  Fly   447 FSLFSAYANNKTFMASLEKSLAKDEQN----YTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSP 507
            |     :.|.....|:     |.|..|    .....:.:..::......|::. .|.|..||:|.
 Worm   529 F-----FTNQLKLEAA-----AMDGTNRRTLVNTHTHQVSGIVVDITAKRVYW-VDPKVDRLESI 582

  Fly   508 NFPGIYPRNLTCYYAVRQHDVPHGKHALILVKQ-------------------PKGNLVWISTQET 553
            ::.|    |.....|...:.||| ...|.|..|                   ....|:|.:|:..
 Worm   583 DYQG----NDRRIVAQGMNVVPH-PFGLALFDQYLYWTDWTRLGVIQVEKFGSDTKLLWSNTENN 642

  Fly   554 ------AAANKMAPP-PSASDKDKKFEPRLKTWNYCDYIQ-ENVKPKWKSTDYVTVYDGYTTRDP 610
                  :|.:.||.| |..|:.     ..:|..|.|.... |.:....|......|  ||....|
 Worm   643 VFPMGISAYHPMAQPGPGQSEC-----LAMKIENPCTNADCEGMCILSKDNGGFGV--GYKCACP 700

  Fly   611 IILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTF-----TGTSSQVLPL-------YGFQLEVEV 663
            |..|...|.:    .:.|...||...:....|.|     ...:..|||:       .|...|||.
 Worm   701 IGQKLVNGKR----CIDSIDYLLFSSNKIVRGIFPEINEKALAEAVLPISPISQRRIGMYFEVEC 761

  Fly   664 Q-------FVDIQSPTYSKNKKPCEFWIRGAGRGILESPKHSLAPNSTCLYHLQGLGVFKTFDHL 721
            .       :.||...|.        :.||..|.|        .||  ..:.|..|| ...:||  
 Worm   762 DVHGNSFFYADIMDNTI--------YRIRPDGEG--------AAP--VLVTHNDGL-FSMSFD-- 805

  Fly   722 SLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTL 786
                                 |||...:.:|.....::...:|..|::...|.....|..   .|
 Worm   806 ---------------------WISKQLYYVDNIRNSLEVVKIGETGLVHPDELVRRQLIT---EL 846

  Fly   787 RDAPVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYA---RPCTISES 848
            || ||                        ||:....:|.:           .||   ||..|...
 Worm   847 RD-PV------------------------SVVVHPWKGLL-----------FYAEAMRPAAIYRC 875

  Fly   849 YVSTSDAITLELRNTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSM--------- 904
            ::...:...  :|||  |:.||.:..     ||..::.|.||    |...|.:|.|         
 Worm   876 HIDGQNCQV--IRNT--TLGRPSEMA-----IDFAENRLCWG----DTLLKTISCMDFDGKNVVK 927

  Fly   905 --MDRKDPAIFR--------------SVRNIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTT 953
              :|...|....              |:|.:.....||:   |.:.:|.|.  ||....::..:.
 Worm   928 LDIDNPIPVAITIMNEYIYYVHQRPYSIRRVHKKNGGGS---KIVREFGAD--ERSIFSLKACSH 987

  Fly   954 TNRPCYSRVDEDINRSFCYGDTNVRIEIFERP--YHDSIL-----LHRGCMCNSSNQSHLPVEYT 1011
            .|:|    :.:|.....|......:: .|..|  .|.:.|     ..:|.|.|..| :|      
 Worm   988 QNQP----IPDDSREHPCRASQCTQL-CFATPSESHPNELEAKCACRQGFMINKEN-NH------ 1040

  Fly  1012 STSRDVEVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSCKDGR------RKFGPSGTIDMT---- 1066
            |..:|.     |:.:..|...::..|:           ||:||      :..|.:..:|.:    
 Worm  1041 SCQKDP-----AEKIEQLCSSNSTQFQ-----------CKNGRCIPKEWKCDGENDCLDESDEID 1089

  Fly  1067 ------FGDVECRSRPWLIEPSNGNKFLYVRL-------------KAIFLSKHNPTQTLNATYVQ 1112
                  |.:.||...  .|:..|..|.:..:.             :.:...|........|...|
 Worm  1090 EKGDKCFHETECAEN--TIKCRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKPVCAAKKFQ 1152

  Fly  1113 TDT-------WRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVEIFSSGWNERPNFALVNRSRA 1170
            .|.       |:|::.:             .|....|    |.:|:..:.......|:..| .|.
 Worm  1153 CDNHRCIPEQWKCDSDN-------------DCGDGSD----EKLEMCGNATCAANQFSCAN-GRC 1199

  Fly  1171 ISVEFLRPGNGE-YS---------------------FNWMELIP-RPTLSMAEDC---------- 1202
            |.:.:|..|:.: |.                     .|..:.:| |.......||          
 Worm  1200 IPIYWLCDGDNDCYDGTDEDKERCPPVQCSALQFRCANGRQCVPLRNHCDGQSDCEDGSDEDSCA 1264

  Fly  1203 ---------QFKCAELGACVNASVWCDGVVHCPSGDDETFLQCSA 1238
                     ||||...|.|:.||..|||...|..|.||....|::
 Worm  1265 VTAESCTPDQFKCVSSGLCIPASWKCDGQQDCDDGSDEPKFGCTS 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 14/30 (47%)
CUB 503..646 CDD:238001 38/174 (22%)
LDLa 1203..1231 CDD:197566 13/27 (48%)
lrp-1NP_001379135.1 LDLa 53..87 CDD:238060
LDLa 92..131 CDD:238060
LDLa 140..173 CDD:238060
LDLa 182..216 CDD:238060
LDLa 223..257 CDD:238060 16/34 (47%)
LDLa 262..297 CDD:238060 3/34 (9%)
LY 463..505 CDD:214531 3/41 (7%)
LY 507..546 CDD:214531 9/50 (18%)
LY 547..589 CDD:214531 8/46 (17%)
LY 883..925 CDD:214531 15/54 (28%)
exchanger_TraA <1054..1451 CDD:411343 51/287 (18%)
LDLa 1057..1087 CDD:197566 7/40 (18%)
LDLa 1146..1177 CDD:197566 7/47 (15%)
LDLa 1187..1219 CDD:238060 7/32 (22%)
LDLa 1228..1263 CDD:238060 5/34 (15%)
LDLa 1270..1302 CDD:238060 13/31 (42%)
LDLa 1313..1344 CDD:238060
FXa_inhibition 1447..1475 CDD:405372
LY 1511..1545 CDD:214531
LY 1548..1585 CDD:214531
LY 1590..1634 CDD:214531
LY 1635..1677 CDD:214531
Ldl_recept_b 1943..1986 CDD:423042
LY 1971..2012 CDD:214531
LY 2015..2052 CDD:214531
LY 2193..2239 CDD:214531
LY 2240..2283 CDD:214531
LY 2284..2325 CDD:214531
LY 2570..2612 CDD:214531
LY 2613..2655 CDD:214531
LDLa 2794..2824 CDD:197566
LDLa 2834..2868 CDD:238060
LDLa 2874..2907 CDD:197566
LDLa 2961..2994 CDD:238060
LDLa 3012..3038 CDD:238060
LDLa 3048..3088 CDD:197566
LDLa 3099..3131 CDD:197566
LDLa 3140..3174 CDD:238060
LDLa 3186..3218 CDD:197566
FXa_inhibition 3276..3305 CDD:405372
LY 3382..3424 CDD:214531
Ldl_recept_b 3445..3490 CDD:395012
LY 3476..3516 CDD:214531
FXa_inhibition 3586..3623 CDD:405372
LDLa 3627..3660 CDD:197566
LDLa 3671..3705 CDD:238060
LDLa 3792..3825 CDD:197566
LDLa 3837..3868 CDD:238060
LDLa 3878..3912 CDD:238060
LDLa 3917..3951 CDD:238060
LDLa 3958..3990 CDD:197566
LDLa 4049..4083 CDD:238060
FXa_inhibition 4097..>4121 CDD:405372
EGF_CA 4132..4163 CDD:214542
NHL 4219..>4431 CDD:302697
NHL repeat 4219..4257 CDD:271320
NHL repeat 4267..4330 CDD:271320
NHL repeat 4333..4371 CDD:271320
NHL repeat 4373..4410 CDD:271320
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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