DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32432 and lrp-2

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_491270.2	Gene:	lrp-2 / 171981	WormBaseID:	WBGene00003072	Length:	4858	Species:	Caenorhabditis elegans

Alignment Length:	1267	Identity:	231/1267 - (18%)
Similarity:	384/1267 - (30%)	Gaps:	417/1267 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 CSLAEFSCS-NGRCVPLSKYCNNLNDCGDGSDE--------PRFCTRCNRTYYGDIGQTYALELH 269
            |...|::|| :.:||||.|:|:...||.|||||        |:....|.   ||.......::.:
Worm   130 CDYNEYACSKSAQCVPLFKFCDGKRDCSDGSDEHSMCHVEDPKTADSCE---YGAAMTIDGIKCY 191

  Fly   270 RPK-------------------QDRVPFVCVL--------TFTAA---------GGQH--GDVVQ 296
            .||                   ::.:|.||..        |||.:         .|.|  .|..|
Worm   192 CPKNKFLNEQGKCEFVNHCERTKNGLPPVCSQDCTDNKNGTFTCSCFDPRLTVVNGTHCVADKDQ 256

  Fly   297 VTLDSFTI-----------GRFTSY-----------------VHEGCPDGYMQI---AESARTPI 330
             |:.|..|           .:.:||                 .|...|:..:.|   :||.....
Worm   257 -TIPSVAILTKKKLFVLQKNKMSSYSSMPRPLGKPGAMTLVIQHPDFPEATVPILCLSESPSAND 320

  Fly   331 GGMWCGSSWG--PVLFYSETRSLIFTIRLNRLAR-DQSGYNFDFRIRYKVLSRDSS----VTRYG 388
            ..:.||:..|  |.   ::|.::.|.:....:.| |..|.|:.|        .|:|    :.::.
Worm   321 SYITCGNVEGSEPA---TKTYAIDFDLSSIHIIRFDNIGNNWIF--------TDASYYVFICKHN 374

  Fly   389 GIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGIL----EDFTNSSVARSD-RYGQDFS 448
            .::::..           :..........|..:..|..|.|    .|.....:.|.| ..||.:.
Worm   375 SVRISSC-----------RTVTAGDMGTIQDMKYDGLNGQLLVSEVDVLQQGIWRIDVASGQRYR 428

  Fly   449 LFSAYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIY 513
            |        ::......:||.|.  :||..|::                |.....:::.::...|
Worm   429 L--------SYQPITSPALAIDP--FTETLYFV----------------DIGARSIKAVDYNANY 467

  Fly   514 PRNLT---CYYAVRQHDVPHGKHALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKF--- 572
            .|.:.   ....|:..|...|:..|.|    |.|.|:       |.|.:     .|:.|.|.
Worm   468 SRTIVSGRIAKEVKMIDYAEGRLFLTL----KDNRVF-------AMNAL-----DSNSDMKIWQE 516

  Fly   573 -EPRLKTWNYCDYIQENV-----------KPKWKS---------------------TDYVTVYDG 604
             .|:.|..|      ||:           :..||:                     |......||
Worm   517 VTPQRKQGN------ENIQILEVLHFRRNEHAWKNKGKNICKAAMCDDMCIGHINQTSSCFCRDG 575

  Fly   605 YTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQ 669
            |...:    ..|...:.:     ...||.|.....|         ..:.:.||......:.:.:.
Worm   576 YIQNN----TKCSASKDL-----KDEELFVLAQLRP---------SRIKILGFDKNYRTEIIGVS 622

  Fly   670 SPTYSKNKKPCEFWIRGAGRGILESPKHSLAPNS-----------TCLYHLQGLGVFKTFDHLSL 723
            .....|......|..:|....:.:..:|||....           |.:.:.:|:....|.|:|.:
Worm   623 DLLNVKRPSAMTFDPKGEQLLMYDLRRHSLVVQKIGSTNYTVHGLTGIMNCEGMAYDFTSDNLYM 687

  Fly   724 S--RRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTL 786
            :  ||..........||..||.:|          |.:......||.:
Worm   688 TDQRRKIITVQRLSNLSIQKVVVS----------GNMSNPRAIAIHI------------------ 724

  Fly   787 RDAPVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESYVS 851
                          ..||...|.:..::                     |:....|..|..|.:.
Worm   725 --------------AKSYLFWGSWNEDN---------------------NDDEKIPAMIERSKLD 754

  Fly   852 TSDAITLELRNTESTVLRPLDFKLKYEFI---DLHQ---DGLPWGGGEHDCNRKFLSSMMDRKDP 910
            .|:..||..:|  :..:..|...||.:::   |.::   :.:.|.|.:.:........:......
Worm   755 GSERKTLVSKN--AMWINGLTLDLKNDYLYWCDAYRNVIERIRWNGADREVVVHGADKISHPYGL 817

  Fly   911 AIFRSVRNIFL--FGRGGTRNLKC--------IYKFEAQRGERVRIKMRKVTTTNRPCYSRVDED 965
            |.|.:  :||.  |.:|..:.:..        ::::.|...|.:..|.....||: ||  ....:
Worm   818 AFFDN--HIFYTEFKKGAVKRVNVDFPDDVQEVFQYSATVFELLVFKNSNPETTS-PC--STSSN 877

  Fly   966 INRSFCYGDT---NVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEYTSTSRDVEVHFIAQN-- 1025
            |...||:..:   :|..|..:....|.:.:.:...|....:...|     .:.|.|:.|...|
Worm   878 ICEHFCFASSCKGSVGCEPVKCGCADGMKVLKNGKCVKDEEWVDP-----NACDNEIEFTCLNSK 937

  Fly  1026 ----MTTLDDPDTVNFEGMFEFVKAPTSCKDGR---RKFGPSGT--IDMTF---GDVECRSRPWL 1078
                .:.|.|.|....:|..|  .|...|||.:   .||...||  :.|.|   |..:|......
Worm   938 KCVPKSNLCDGDDDCGDGSDE--DANGICKDYKCVGNKFQCDGTTCLPMEFICDGKSDCYDGTDE 1000

  Fly  1079 IEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSR---AVLTTSEGLTIVACPLS 1140
            :|.               :.|..|....:.:..|....:|..||:   .|.....|.....||.|
Worm  1001 LEK---------------ICKKAPIVKCSVSQFQCSKTKCIIKSKRCNGVQECDNGADEEDCPRS 1050

  Fly  1141 PDSNAYEF-----------------VEIFSSGWNERPNFALVNRSRAISVEFLRPGNGEYSFNWM 1188
            ...:..||                 ::.......|..|    ...:.:.....|..||:.:  .:
Worm  1051 KLCDPDEFRCGTGLCIKQSQVCDGKMQCLDGLDEEHCN----EEEKCLQGRQFRCANGKST--CL 1109

  Fly  1189 ELIPRPTLSMAEDC-----------------------QFKCAELGACVNASVWCDGVVHCPSGDD 1230
            :||.|  .....||                       ||.||: |.|:.:...|||...|.:|:|
Worm  1110 DLIFR--CDGVADCEDSSDESDEFCKGNSSSTCGKMNQFMCAD-GKCLRSFQLCDGFPDCLTGED 1171

  Fly  1231 ETFLQCSALMKLPAEILATL----CLIFVLSC 1258
            ||  :|...|......|:.|    |:...|.|
Worm  1172 ET--ECPPSMCDSTTHLSCLNGQKCISKQLEC 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	15/31 (48%)
		CUB	503..646	CDD:238001	31/181 (17%)
		LDLa	1203..1231	CDD:197566	11/27 (41%)
lrp-2	NP_491270.2	LDLa	80..119	CDD:197566
		LDLa	130..162	CDD:197566	15/31 (48%)
		LY	668..702	CDD:214531	7/33 (21%)
		LY	707..758	CDD:214531	14/113 (12%)
		LY	759..801	CDD:214531	9/43 (21%)
		LDLa	968..1000	CDD:197566	8/31 (26%)
		LDLa	1013..1047	CDD:238060	6/33 (18%)
		LDLa	1053..1087	CDD:238060	3/33 (9%)
		LDLa	1098..1129	CDD:238060	8/34 (24%)
		LDLa	1144..1175	CDD:238060	14/33 (42%)
		LDLa	1182..1216	CDD:238060	5/20 (25%)
		FXa_inhibition	1276..1305	CDD:291342
		LY	1421..1463	CDD:214531
		LY	1465..1508	CDD:214531
		LY	1521..1555	CDD:214531
		LY	2480..2521	CDD:214531
		LDLa	2681..2715	CDD:238060
		LDLa	2717..2751	CDD:238060
		LDLa	<2774..2798	CDD:238060
		LDLa	2819..2851	CDD:238060
		LDLa	2856..2891	CDD:238060
		LDLa	2904..2938	CDD:238060
		LDLa	2988..3020	CDD:197566
		LY	3231..3270	CDD:214531
		Ldl_recept_b	3296..3336	CDD:278487
		LY	3319..3362	CDD:214531
		LY	3363..3404	CDD:214531
		LDLa	3481..3514	CDD:197566
		LDLa	3574..3609	CDD:238060
		LDLa	3614..3649	CDD:197566
		LDLa	3659..3693	CDD:238060
		LDLa	3881..3912	CDD:238060
		LY	4084..4125	CDD:214531
		LY	4139..4181	CDD:214531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900