DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32432 and Lrp1

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus


Alignment Length:1579 Identity:277/1579 - (17%)
Similarity:437/1579 - (27%) Gaps:704/1579 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CSLAEFSCSNGR--CVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYG------------------ 258
            |......|:|..  |:|..|.|:..:||||||||...|.:|:....|                  
Mouse  1163 CRPPSHPCANNTSVCLPPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCP 1227

  Fly   259 ---DIG--------QTYA----------------------------------------------- 265
               ::|        |:|.                                               
Mouse  1228 LGMELGSDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFS 1292

  Fly   266 -------LELHRPKQDRVPFVCVLTFTAAGGQH--------GDVVQ------VTLDSFTIGRFTS 309
                   ::||  |.|....|..|..|.|...|        .|||:      ..||:..:..|..
Mouse  1293 NRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEV 1355

  Fly   310 YVHEG--CPDG------------------YMQIAE---SART----------------PIGGMWC 335
            .:..|  .|:|                  .:::|:   :.||                |..|:..
Mouse  1356 VIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILF 1420

  Fly   336 GSSW-------------------------------GPVLFYSETRSLIFTIRLNRL--AR-DQSG 366
            .:.|                               |..:.|.|.|.|....|.:.:  || |.||
Mouse  1421 WTDWDASLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1485

  Fly   367 YNFDFRIRYKVLSRDSSVTRYGG---------IKLAELAQW--HNRSSFLNQQQQQQQQQQQQQQ 420
            :....| .::.||...:||.|||         ..||:..:|  ||.:.......|....|.....
Mouse  1486 HMEVLR-GHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPS 1549

  Fly   421 QQQGAPGILE--------------DFTNSSVA----------RSDRYGQDFSLFSAYAN------ 455
            :|..||...|              :: |.:|:          :.:....:|..|..||.      
Mouse  1550 RQPMAPNPCEANGGRGPCSHLCLINY-NRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRG 1613

  Fly   456 ---NKTFMASLEKSLAKDEQNYT-------EPKYYLGDL---------IPGTYCSRIFS------ 495
               :..:...:......|..|.|       |.:.|..|:         |.||....:.|      
Mouse  1614 VDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNA 1678

  Fly   496 -----------------DCDKKPCR---------------LQSPNFPGIYPRNLTCYYA----VR 524
                             |.:||...               |:.|:...::|.....|:.    :.
Mouse  1679 HGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNIS 1743

  Fly   525 QHDVPHGKHALILVKQ----------PKGNLVWIST--------------------------QET 553
            ..::....|.|:...|          |:..|.|||:                          :.|
Mouse  1744 MANMDGSNHTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMRSQLGKAT 1808

  Fly   554 AAA---NKMAPPPSASDKDKKFEPRLKTWNYCD------------------YIQENVKPKWKSTD 597
            |.|   :|:......|:|       :.|.|..|                  ...|:::.:.:.|:
Mouse  1809 ALAIMGDKLWWADQVSEK-------MGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQLEHEGTN 1866

  Fly   598 YVTVYDG----------YTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTF-------- 644
            ..:|.:|          .|||..:    |..|.    ::.||.:     :....|:|        
Mouse  1867 PCSVNNGDCSQLCLPTSETTRSCM----CTAGY----SLRSGQQ-----ACEGVGSFLLYSVHEG 1918

  Fly   645 --------TGTSSQVLPLYGFQLEVEVQF---------VDIQSPTYSKNKKPCEFW-----IRGA 687
                    ...|..::|:.|..|.|.:.|         ||:...|.|:.|:. :.|     ..|.
Mouse  1919 IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRD-QTWREDVVTNGI 1982

  Fly   688 GRGILESPKHSLAPNSTCLYHLQGLGV----------FKTFDHLSLSRRTSS------QSGMHQP 736
            ||                   ::|:.|          .:.||.:.::|...|      ..|:.:|
Mouse  1983 GR-------------------VEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKP 2028

  Fly   737 LSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDAPVCKDLNCATET 801
            .:          ..:.||.|.:..|.                   |                   
Mouse  2029 RA----------ITVHPEKGYLFWTE-------------------W------------------- 2045

  Fly   802 SSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESY-----------VSTSDA 855
                  |||        .|..|..:..|.....:|.:.:.|..||..|           :...:.
Mouse  2046 ------GHY--------PRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIER 2096

  Fly   856 ITLELRNTESTVLRPLDFKLKYEF-IDLHQDGLPWGGGEH-------DCNRKFLSSM-------M 905
            |.||.......||...:..:   | :.:.:|.:.|....|       .|......|:       :
Mouse  2097 IDLETGENREVVLSSNNMDM---FSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGV 2158

  Fly   906 DRKDPAIFRSVR----NIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPC-------- 958
            ..||..:|...|    |:.....||.:.| |:|:...||.......|  :......|        
Mouse  2159 QLKDIKVFNRDRQKGTNVCAVANGGCQQL-CLYRGGGQRACACAHGM--LAEDGASCREYAGYLL 2220

  Fly   959 YSRVDEDINRSFCYGD---TNVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEY-TSTSRDV-- 1017
            ||  :..|.:|....|   .|..::.||.|.|            ..|...|..:| ..||...  
Mouse  2221 YS--ERTILKSIHLSDERNLNAPVQPFEDPEH------------MKNVIALAFDYRAGTSPGTPN 2271

  Fly  1018 -----EVHF---------------IAQNMTTLDDP------DTVNF-----------------EG 1039
                 ::||               |.:|:.:::..      ||:.:                 .|
Mouse  2272 RIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPG 2336

  Fly  1040 MFEFVKAPT-SCKDGRRKFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPT 1103
            .||.....| |..|..|.|    .:|      ||::   |:..:|.|: |:..:....||..| .
Mouse  2337 AFERETVITMSGDDHPRAF----VLD------ECQN---LMFWTNWNE-LHPSIMRAALSGAN-V 2386

  Fly  1104 QTLNATYVQTDTW---------------------RCE--TKSRAVLTTSEGLTIVACPLSPDSNA 1145
            .||....::|...                     |||  ...|.|:..||       |:.|...|
Mouse  2387 LTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSE-------PVHPFGLA 2444

  Fly  1146 YEFVEIFSSGW----NERPNFALVNRSRAISVEFLRPGNGEYSF----NWMELIP---------- 1192
            .....||.:.|    .:|.|..:.:..:.:.|:..:...|..:.    |..||.|          
Mouse  2445 VYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQD 2509

  Fly  1193 --------------RPTLSMAED---------C----QFKCAELGACVNASVWCDGVVHCPSGDD 1230
                          |....:.||         |    :|:||. |.|::.|:.||||.||....|
Mouse  2510 LCLLTHQGHVNCSCRGGRILQEDFTCRAVNSSCRAQDEFECAN-GECISFSLTCDGVSHCKDKSD 2573

  Fly  1231 E------------TFLQCS 1237
            |            ||.||:
Mouse  2574 EKPSYCNSRRCKKTFRQCN 2592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 13/32 (41%)
CUB 503..646 CDD:238001 34/244 (14%)
LDLa 1203..1231 CDD:197566 12/27 (44%)
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:405372
FXa_inhibition 159..189 CDD:405372
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:405372
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:405372
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060 13/32 (41%)
FXa_inhibition 1203..1239 CDD:405372 3/35 (9%)
LY 1354..1394 CDD:214531 4/39 (10%)
LY 1398..1441 CDD:214531 3/42 (7%)
LY 1442..1486 CDD:214531 10/43 (23%)
LY 1631..1667 CDD:214531 9/35 (26%)
LY 1668..1711 CDD:214531 4/42 (10%)
LY 1715..1752 CDD:214531 4/36 (11%)
LY 1752..1793 CDD:214531 8/40 (20%)
FXa_inhibition 1868..1904 CDD:405372 9/48 (19%)
LY 1934..1974 CDD:214531 10/40 (25%)
LY 1977..2017 CDD:214531 9/58 (16%)
LY 2018..2061 CDD:214531 13/104 (13%)
LY 2063..2105 CDD:214531 8/41 (20%)
FXa_inhibition 2177..2212 CDD:405372 8/37 (22%)
YvrE 2271..2481 CDD:225921 43/231 (19%)
Ldl_recept_b 2362..2403 CDD:395012 10/45 (22%)
LY 2388..2429 CDD:214531 6/40 (15%)
FXa_inhibition 2500..2532 CDD:405372 1/31 (3%)
LDLa 2545..2575 CDD:238060 13/30 (43%)
LDLa 2584..2618 CDD:238060 4/9 (44%)
LDLa 2623..2657 CDD:238060
LDLa <2684..2706 CDD:238060
LDLa 2714..2748 CDD:238060
LDLa 2752..2783 CDD:197566
LDLa 2791..2824 CDD:197566
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
cEGF 2980..3003 CDD:403760
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:405372
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4071 CDD:395012
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.