DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Lrp2

DIOPT Version :9

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_001074557.1 Gene:Lrp2 / 14725 MGIID:95794 Length:4660 Species:Mus musculus


Alignment Length:1239 Identity:235/1239 - (18%)
Similarity:341/1239 - (27%) Gaps:491/1239 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCT--------------RCNRTYY------- 257
            ||..||||:||||:..|..|:..|||||.||| |.|:              :|....|       
Mouse  2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDE-RGCSYPPCRDDQFTCQNGQCITKLYVCDEDND 3058

  Fly   258 -GDIGQTYALELHRPKQDRVPFV-------CVLTFTAAGGQHGDVVQVTLDSFTIG------RFT 308
             ||.........|.|:....|..       |:...|..  .|.|......|....|      ...
Mouse  3059 CGDGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVC--NHVDDCSDNSDEKGCGINECQDSSI 3121

  Fly   309 SYVHEGCPD-----------GY---------MQIAESARTP----------IGGMWC-------- 335
            |:....|.|           ||         :.|.|...||          ||...|        
Mouse  3122 SHCDHNCTDTITSFYCSCLPGYKLMSDKRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIR 3186

  Fly   336 ---------GSSWGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIK 391
                     .|:..|.|.:|..    :.||  .|..|.:.|:.       :|....:|......:
Mouse  3187 EPDGKSCRQNSNIEPYLVFSNR----YYIR--NLTIDGTSYSL-------ILQGLGNVVALDFDR 3238

  Fly   392 LAELAQWHNRSS------FLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLF 450
            :.|...|.:...      |||:                         ||.....|.|..:..||.
Mouse  3239 VEERLYWIDAEKQIIERMFLNK-------------------------TNQETIISHRLRRAESLA 3278

  Fly   451 SAYANNK----------TFMASLE----KSLAK---DEQNYTEPKYYLGDLIPGTYCSRIFSDCD 498
            ..:.:.|          .|::.||    |.||:   |..|              |:|        
Mouse  3279 VDWVSRKLYWLDAILDCLFVSDLEGRQRKMLAQHCVDANN--------------TFC-------- 3321

  Fly   499 KKPCRLQSPNFPGIYPRNLTCYYAVRQHDVPHGKHALILVKQPKGNLVWISTQETAAANKMAPPP 563
                 .::|....::|:....|:|      ..|.||.|      ..:....|.:|...:.....|
Mouse  3322 -----FENPRGIVLHPQRGYVYWA------DWGDHAYI------ARIGMDGTNKTVIISTKIEWP 3369

  Fly   564 SASDKDKKFEPRLKTW--NYCDYIQ-ENVKPKWKSTDYVTVYDGYTTRDPIIL------------ 613
            :|...|  :...|..|  .:..||: .:::...:.    ||||| |...|..|            
Mouse  3370 NAITID--YTNDLLYWADAHLGYIEFSDLEGHHRH----TVYDG-TLPHPFALTIFEDTVFWTDW 3427

  Fly   614 ---------KFCGGGQAVPAAVSSGP-ELLV------EFSTSPFGTFTGTSSQVLPL----YGFQ 658
                     |:.|.|:.|....:..| ::.|      ...::|..|..|..|.:..:    .||.
Mouse  3428 NTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVLHPYRQPIMSNPCATNNGGCSHLCLIKAGGRGFT 3492

  Fly   659 LEVEVQFVDIQ-----------SPTY---SKNKKPCEFWIRGAGRGILE--SPKHSLAPNSTCLY 707
            .|....|..:|           |.|.   ..|:|....|.:..|:....  |.:..|.|:..|  
Mouse  3493 CECPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDESDLCPHRFC-- 3555

  Fly   708 HLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQ 772
               .||.|:..|    ...||.|:                                    :...:
Mouse  3556 ---RLGQFQCRD----GNCTSPQA------------------------------------LCNAR 3577

  Fly   773 EDCSGMLRIWDGTLRDAPVCKDLNC-ATETSSYN---------------TLGHYTHNSTSVIARF 821
            :||:      ||:..|..:|:...| |.|....|               .|.:...:.:...:|.
Mouse  3578 QDCA------DGSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHCASRT 3636

  Fly   822 CR---------GTIPRT--CDRSNINETYARPCTISESYVSTSDAITLELRNTESTVLRPLDFKL 875
            ||         ..||::  ||..|....|             ||....|............:|..
Mouse  3637 CRPGQFKCNNGRCIPQSWKCDVDNDCGDY-------------SDEPIHECMTAAYNCDNHTEFSC 3688

  Fly   876 KYEFIDLHQDGLPWG--GGEHDCNRKFLSSMMDRKDPAIFRSVRNIFLFGRGGTRNLKCIYKFEA 938
            |..:..:.|    |.  .|..||.        |..|.....||                      
Mouse  3689 KTNYRCIPQ----WAVCNGFDDCR--------DNSDEQGCESV---------------------- 3719

  Fly   939 QRGERVRIKMRKVTTTNRPCYSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGC----MC- 998
                              ||:...|                  |....|..|.|...|    .| 
Mouse  3720 ------------------PCHPSGD------------------FRCGNHHCIPLRWKCDGIDDCG 3748

  Fly   999 -NSSNQSHLPVEYTSTSRDVEVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGPSGT 1062
             ||..:|.:|.|.|.:                            ||..|...|...|........
Mouse  3749 DNSDEESCVPRECTES----------------------------EFRCADQQCIPSRWVCDQEND 3785

  Fly  1063 IDMTFGDVECRSR---PWLIEPSNGN---KFLYVRLKAIFLSKHN----PTQTLNATY------- 1110
            ......:.:|..:   |...:.::|:   |.|....:|..|...:    ||:..|.||       
Mouse  3786 CGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFE 3850

  Fly  1111 ------VQTDTWRCETKSRAVLTTSEGLTI---VACPLSPDSNAYEFVEIFSSGWNERPNFALVN 1166
                  :|: .|.|:.::..|..:.|.:.:   |.|                    |.|.....:
Mouse  3851 CKNHVCIQS-FWICDGENDCVDGSDEEIHLCFNVPC--------------------ESPQRFRCD 3894

  Fly  1167 RSRAISVEFLRPG---NGEYSFNWMELIPRPTLSMAEDCQFKCAELGACVNASVWCDGVVHCPSG 1228
            .||.|....|..|   .|:.|....|...:||.....|.::||:. |.||:....||.|..|...
Mouse  3895 NSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSN-GNCVSQHYVCDNVDDCGDL 3958

  Fly  1229 DDET 1232
            .|||
Mouse  3959 SDET 3962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 18/30 (60%)
CUB 503..646 CDD:238001 33/173 (19%)
LDLa 1203..1231 CDD:197566 9/27 (33%)
Lrp2NP_001074557.1 LDLa 28..62 CDD:238060
LDLa 67..99 CDD:197566
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477
LY 460..500 CDD:214531
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520
LY 502..547 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567
LY 550..590 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612
FXa_inhibition 662..703 CDD:291342
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794
LY 775..817 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880
Ldl_recept_b 837..877 CDD:278487
LY 863..903 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924
FXa_inhibition 980..1012 CDD:291342
LDLa 1025..1059 CDD:238060
Ldl_recept_a 1065..1101 CDD:278486
LDLa 1110..1144 CDD:238060
LDLa 1150..1184 CDD:238060
LDLa 1188..1223 CDD:238060
LDLa 1231..1263 CDD:197566
LDLa 1272..1306 CDD:238060
LDLa 1313..1345 CDD:197566
FXa_inhibition 1354..1389 CDD:291342
EGF_CA 1391..1430 CDD:214542
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521
LY 1502..1544 CDD:214531
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564
LY 1546..1590 CDD:214531
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610
LY 1592..1633 CDD:214531
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931
Ldl_recept_b 1884..1928 CDD:278487
LY 1912..1954 CDD:214531
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014
FXa_inhibition 2023..2059 CDD:291342
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202
LY 2183..2226 CDD:214531
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246
LY 2228..2268 CDD:214531
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2291..2333
FXa_inhibition 2347..2383 CDD:291342
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478
LY 2460..2501 CDD:214531
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519
LY 2503..2543 CDD:214531
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647
FXa_inhibition 2656..2693 CDD:291342
LDLa 2700..2732 CDD:197566
LDLa 2742..2776 CDD:238060
LDLa 2783..2818 CDD:238060
LDLa 2822..2855 CDD:197566
LDLa 2865..2899 CDD:238060
LDLa 2908..2939 CDD:197566
LDLa 2950..2986 CDD:197566
LDLa 2995..3029 CDD:238060 21/34 (62%)
LDLa 3034..3066 CDD:238060 4/31 (13%)
LDLa 3077..3111 CDD:238060 6/35 (17%)
cEGF 3134..3157 CDD:289433 3/22 (14%)
vWFA <3149..3192 CDD:294047 7/42 (17%)
LY 3221..3262 CDD:214531 8/72 (11%)
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283 11/66 (17%)
LY 3264..3306 CDD:214531 8/41 (20%)
Ldl_recept_b 3284..3331 CDD:278487 12/73 (16%)
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326 11/68 (16%)
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378 11/56 (20%)
Ldl_recept_b 3335..3375 CDD:278487 10/51 (20%)
LY 3360..3401 CDD:214531 7/42 (17%)
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421 12/46 (26%)
LY 3406..3443 CDD:214531 7/37 (19%)
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462 6/39 (15%)
FXa_inhibition 3471..>3500 CDD:291342 6/28 (21%)
LDLa 3514..3548 CDD:238060 7/33 (21%)
LDLa 3555..3586 CDD:197566 12/81 (15%)
LDLa 3595..3627 CDD:197566 5/31 (16%)
LDLa 3636..3668 CDD:197566 9/44 (20%)
LDLa 3684..3716 CDD:238060 9/43 (21%)
LDLa 3723..3756 CDD:238060 9/50 (18%)
LDLa 3761..3795 CDD:238060 6/61 (10%)
LDLa 3800..3834 CDD:238060 6/33 (18%)
LDLa 3844..3876 CDD:238060 4/32 (13%)
LDLa 3887..3917 CDD:197566 8/29 (28%)
LDLa 3930..3964 CDD:238060 13/34 (38%)
EGF_CA 4009..4049 CDD:214542
LY 4143..4178 CDD:214531
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242
Ldl_recept_b 4199..4239 CDD:278487
LY 4224..4266 CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285
SH3-binding. /evidence=ECO:0000255 4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4460..4465
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4558..4660
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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