DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32432 and lrp3

DIOPT Version :9

Sequence 1:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_009301583.1	Gene:	lrp3 / 100170796	ZFINID:	ZDB-GENE-080116-3	Length:	824	Species:	Danio rerio

Alignment Length:	706	Identity:	134/706 - (18%)
Similarity:	194/706 - (27%)	Gaps:	284/706 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 GSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCT----------------RCNRTY 256
            |.||  |...|:.|.||:|||.|..||.|::|||.:|| |.|.                :|:
Zfish   147 GQSS--CEKDEYLCGNGKCVPRSWRCNGLDECGDNTDE-RNCVAPPTPARASLCPPGTLQCS--- 205

  Fly   257 YGDIGQTYALELHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQ 321
              |:..|..|.                                     |.........||||
Zfish   206 --DVQSTRCLP-------------------------------------GSLRCNGARDCPDG--- 228

  Fly   322 IAESARTPIGGMWCGSSWGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRD----- 381
             ::.||.|  ...||...  |.||....|..| .|.||      ....|....:.:.::|
Zfish   229 -SDEARCP--DTSCGKRL--VNFYGTFASPDF-FRPNR------STGTDLHCTWFLDTKDPKPLV 281

  Fly   382 ----------SSVTRYGGI-----KLAELAQWHN--RSSFLNQQQQQQQQQQQQQQQQQGAPGIL 429
                      .||..|.|:     :|.:....||  |.:.|...|.|.......:....|
Zfish   282 LQVDLQLGVGDSVRVYDGLGEQAERLLQSLSHHNNHRRALLESSQGQMSIFYHAKPHSPG----- 341

  Fly   430 EDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIF 494
                         :|     |:|....|.:....|.....||..|::.:...|           :
Zfish   342 -------------HG-----FNATYQVKGYCFPGEHPCGTDEGCYSDLQRCDG-----------Y 377

  Fly   495 SDC----DKKPCRLQSPNFPGIYP---RNLTCYYAVRQHDVPHGKHALILVKQPKGNLVWISTQE 552
            ..|    |::.|.|..   ||.||   .:..||.|
Zfish   378 WHCPGGRDEEACPLCQ---PGEYPCEGGSGACYSA------------------------------ 409

  Fly   553 TAAANKMAPPPSASDKDKKFEPRLKTW----NYCDYIQENVKPKWKSTDYVTVYDGYTTRDPIIL 613
            :...|.....|..||:...|:.:...:    |.|      :...|:........||...||.:
Zfish   410 SERCNNQKKCPDGSDEKNCFDCQPGNFHCGTNLC------IFETWRCDGQEDCMDGSDERDCL-- 466

  Fly   614 KFCGGGQAVPAAVSSGPEL------------------LVEFSTSPFGTF----TGTSSQVL---- 652
                  .:||..|.:...:                  |....|..:..|    |...::.:
Zfish   467 ------ASVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTREYRAFETQMTRLEAEFVQREA 525

  Fly   653 -PLYGFQLEVE-----VQFVDIQSPTY-----------------------SKNKKPCEFWIRGAG 688
             |.|| ||..:     |....:.:||.                       |..::....|.|...
Zfish   526 PPSYG-QLIAQGLIPPVDDFPVYNPTQASVLQNLRSAMRRQIRRHSSRRSSSRRRLGRLWNRLFH 589

  Fly   689 RG--------ILESPKHSLA---------------------PNST------CLYHLQGLGVFKTF 718
            ||        :|..|.|:.|                     |.:|      |.....||.:....
Zfish   590 RGSRVRGQIPLLTPPGHTHANTYPELNLHSYNTADNSVRESPETTGQTPPSCSAVALGLALQAQN 654

  Fly   719 DHLSLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQED 774
            |.|.|..|.|..|.:..|....   :......|:.|..:.|.:|.|..|:|...:|
Zfish   655 DALCLPDRESPASPLSLPSPNS---LHSTSDTLEDEDDEDDRSSAGKQGILAKHKD 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	15/30 (50%)
		CUB	503..646	CDD:238001	26/171 (15%)
		LDLa	1203..1231	CDD:197566
lrp3	XP_009301583.1	CUB	31..141	CDD:238001
		LDLa	151..185	CDD:238060	18/34 (53%)
		LDLa	197..234	CDD:238060	10/82 (12%)
		CUB	239..350	CDD:238001	27/142 (19%)
		LDLa	354..389	CDD:238060	7/45 (16%)
		LDLa	392..428	CDD:238060	11/68 (16%)
		LDLa	431..465	CDD:238060	6/39 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900