DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11456 and Zbtb21

DIOPT Version :9

Sequence 1:	NP_001262130.1	Gene:	CG11456 / 40309	FlyBaseID:	FBgn0037031	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_780637.2	Gene:	Zbtb21 / 114565	MGIID:	1927240	Length:	1094	Species:	Mus musculus

Alignment Length:	443	Identity:	87/443 - (19%)
Similarity:	153/443 - (34%)	Gaps:	115/443 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENSARIVYVCSLCLRQYDLQEDLRGHLVYFHGYEPISTPSVKNKTAKTSTKEQTAAGSNSQDKQ 65
            :.:.|:..|:|:.|.:.|......:.|:....|..|:..    ::.||...:....|..|
Mouse   693 LRSRAKGAYICAYCGKAYRFLSQFKQHIKMHPGERPLGV----SRAAKPKERALARAVEN----- 748

  Fly    66 TVVERSENSEPPASELQPMPFKDFRLVLRANMLEP------CSFGKECPF----KFQDATKMELH 120
                         .|:.|....:.:|   :::||.      |.....||:    .|..|.|.|..
Mouse   749 -------------KEVYPCRLCNAKL---SSLLEQGNHERLCRNATVCPYCSLRFFSPALKQEHE 797

  Fly   121 CSC-HKGGSFSCCECGMELPNWRRCSAHLWKAHQVDV----DLLVCPVF---------------- 164
            ..| :|  ..:|.||....    :.|..:|: |||:|    ::.:...|
Mouse   798 DRCEYK--KLTCLECMRTF----KSSFSIWR-HQVEVHNQNNMALAENFALATLDHNGEVAAASR 855

  Fly   165 -------------------------ECNYKSPISALVWRHMQVHKKWRPRVLRSLAAVQRRRKLK 204
                                     :.|:.|..|:.:...:.:.|:.:         ||.:.:..
Mouse   856 PQTEPSKVNHVATPKEDTAFSDSSEQVNFDSEDSSCLPEDLSLSKQLK---------VQVKEEPV 911

  Fly   205 EQSAEMAAQPAALPPSSKKNKYYAEKTCEICNRKFVNGKTLSKHVKTVHNKIKPFICNVCGKKTA 269
            |::.|.|.:.:|.|..:..:|......||.|.:.|...|.|.:|.:.:.: :|||||:||.|...
Mouse   912 EEAEEEAPEASAAPREAGPSKETGLWPCEKCGKMFTAHKQLERHQELLCS-VKPFICHVCYKAFR 975

  Fly   270 RKASLIIHMRQHTG---EKPLQ--CGECKFSTRDPS--------VLHKHRQRHDSQDT---RSSL 318
            ....|..|.:.|..   |:|:|  ...|...|..||        .|.|.:.......|   .:..
Mouse   976 TNFRLWSHFQTHMSQATEEPVQKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLPENPT 1040

  Fly   319 KCSQCDYFCIQANALKRHM-RLNHAEAYRDLCCDICSFTSINVERLRAHKQDH 370
            ..::..:...:::.|..|. .|:.....|...|.:|..|......|.:|:|.|
Mouse  1041 PATEKLFAPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTH 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11456	NP_001262130.1	C2H2 Zn finger	232..253	CDD:275368	7/20 (35%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..309	CDD:275368	6/27 (22%)
Zbtb21	NP_780637.2	BTB_POZ_ZBTB21_ZNF295	40..151	CDD:349518
		SUF4-like	576..>629	CDD:411020
		C2H2 Zn finger	579..600	CDD:411020
		C2H2 Zn finger	579..600	CDD:275368
		C2H2 Zn finger	608..629	CDD:411020
		zf-C2H2	701..723	CDD:395048	5/21 (24%)
		C2H2 Zn finger	703..723	CDD:275370	4/19 (21%)
		zf_C2H2_6	776..803	CDD:408245	7/26 (27%)
		C2H2 Zn finger	939..959	CDD:275370	7/19 (37%)
		C2H2 Zn finger	967..988	CDD:275370	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100