DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11456 and ZNF316

DIOPT Version :9

Sequence 1:	NP_001262130.1	Gene:	CG11456 / 40309	FlyBaseID:	FBgn0037031	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001265488.1	Gene:	ZNF316 / 100131017	HGNCID:	13843	Length:	1004	Species:	Homo sapiens

Alignment Length:	295	Identity:	84/295 - (28%)
Similarity:	115/295 - (38%)	Gaps:	82/295 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 AQPAAL-PPSSKKNKYYAEKTCEICNRKFVNGKTLSKHVKTVHNKIKPFICNVCGKKTARKASLI 275
            |.|||: ||:.:     .|.||::|.:.|.:...|:|| :..|..:|||.|..|||....::.|.
Human   331 AFPAAVAPPAGR-----PETTCDVCGKVFPHRSRLAKH-QRYHAAVKPFGCEECGKGFVYRSHLA 389

  Fly   276 IHMRQHTGEKPLQCGEC--KFSTRDPSVLHK--------------------------HRQRHDSQ 312
            ||.|.||||||..|.:|  :|..:...|.|:                          |::.|..:
Human   390 IHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGE 454

  Fly   313 DTRSSLKCSQCDYFCIQANALKRHMRLNHAEAYRDLCCDICSFTSINVERLRAHKQDHRQGLITN 377
               ....||.|.....|::||.||..::.|:  |..||..|.    ...||||..|.||:|  ..
Human   455 ---RPYPCSHCGRSFSQSSALARHQAVHTAD--RPHCCPDCG----QAFRLRADFQRHRRG--GG 508

  Fly   378 C----------EDSMDARAAGFKYPR---------KVGDKNGEISADCF----------MPLESV 413
            |          |....|.|||   |.         :||:.:||..|...          .|...|
Human   509 CAEAGGDGPRREPGETAAAAG---PEDTDPGPEGSEVGEADGEAEAAAEEREEAAVAAPTPSGKV 570

  Fly   414 DSLPHEPALDTG-GVTIPAPPSEDT---QFPTYLK 444
            |..|....|:.| |:.....||...   .||.:.|
Human   571 DPAPERRFLELGNGLGEGEGPSSHPLGFHFPVHPK 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11456	NP_001262130.1	C2H2 Zn finger	232..253	CDD:275368	6/20 (30%)
		C2H2 Zn finger	261..281	CDD:275368	8/19 (42%)
		C2H2 Zn finger	289..309	CDD:275368	6/47 (13%)
ZNF316	NP_001265488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148
		KRAB	158..218	CDD:214630
		COG5048	<345..503	CDD:227381	50/167 (30%)
		C2H2 Zn finger	347..367	CDD:275368	6/20 (30%)
		C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	1/19 (5%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		C2H2 Zn finger	487..505	CDD:275368	8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..574		15/68 (22%)
		C2H2 Zn finger	693..713	CDD:275368
		zf-H2C2_2	705..730	CDD:316026
		C2H2 Zn finger	721..741	CDD:275368
		COG5048	<746..933	CDD:227381
		C2H2 Zn finger	749..769	CDD:275368
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		C2H2 Zn finger	861..881	CDD:275368
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..976
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100