DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN3 and cops3

DIOPT Version :9

Sequence 1:	NP_524190.2	Gene:	CSN3 / 40308	FlyBaseID:	FBgn0027055	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_955979.1	Gene:	cops3 / 335720	ZFINID:	ZDB-GENE-030131-7660	Length:	423	Species:	Danio rerio

Alignment Length:	436	Identity:	222/436 - (50%)
Similarity:	300/436 - (68%)	Gaps:	20/436 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSALENYVNQVRTLSASGSYRELAEELPESLSLLARNWSILDNVLETLDMQQHSLGVLYVLLAK 65
            |.||||.:||.||.|||.|...:|.|.:.:|..||::|.|.||.||..||:|:||||||.||..|
Zfish     1 MASALEQFVNNVRQLSAQGQMTQLCELINKSGELLSKNLSHLDTVLGALDIQEHSLGVLAVLFVK 65

  Fly    66 LHSASTAN-PEPVQLIQLMRDFVQRNNNEQLRYAVCAFYETCHLFTEFVVQKNLSILGIRIISRA 129
            .   |..| |:...|...::.|:...|.|.:|||...|...||..|..:|::...:.||.|:.:|
Zfish    66 F---SMPNIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGISILKQA 127

  Fly   130 IDQIRQLETQLTPIHADLCLLSLKAKNFSVVLPYLDADITDISTVAAECKTQQQQQSQHADANND 194
            ||:::....|||.:|||||.|.|.||.|...:|:|:.|:.||      ||         .:...|
Zfish   128 IDKMQMNTNQLTSVHADLCQLCLLAKCFKPAVPFLELDMMDI------CK---------ENGAYD 177

  Fly   195 AKYFLLYFYYGGMIYTAVKNYERALYFFEVCITTPAMAMSHIMLEAYKKFLMVSLIVEGKIAYIP 259
            ||:||.|:||||||||.:||:||||||||..|||||||:||||||||||:::||||:.||:..:|
Zfish   178 AKHFLCYYYYGGMIYTGLKNFERALYFFEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQLP 242

  Fly   260 KNT-QVIGRFMKPMANHYHDLVNVYANSSSEELRIIILKYSEAFTRDNNMGLAKQVATSLYKRNI 323
            |.| |::|||:||::|.||:|..:||.::..|||.::.|:||.||||||.||.||..:||||:||
Zfish   243 KYTSQIVGRFIKPLSNAYHELAQIYATNNPAELRALVNKHSETFTRDNNSGLVKQCLSSLYKKNI 307

  Fly   324 QRLTKTFLTLSLSDVASRVQLASAVEAERYILNMIKSGEIYASINQKDGMVLFKDDPEKYNSPEM 388
            ||||||||||||.|:||||||:...|||:|:|:||:.||||||||||||||.|.|:|||||:|.|
Zfish   308 QRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIYASINQKDGMVCFHDNPEKYNNPAM 372

  Fly   389 FLNVQNNITHVLDQVRQINKMEEEIILNPMYVKKALGSQDDDLTSQ 434
            ...:...:...::...::..|::||.:||.:|:|::|:|:||:.|:
Zfish   373 LHKIDQEMLKCIELDEKLKSMDQEITVNPQFVQKSMGTQEDDVGSK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN3	NP_524190.2	PCI	275..378	CDD:279707	68/102 (67%)
cops3	NP_955979.1	PCI	259..362	CDD:279707	68/102 (67%)
cops3	NP_955979.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..423		7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2710
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1744
OMA	1	1.010	-	-		QHG55351
OrthoDB	1	1.010	-	-		D453056at33208
OrthoFinder	1	1.000	-	-		FOG0005586
OrthoInspector	1	1.000	-	-		oto39299
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6002
SonicParanoid	1	1.000	-	-		X5221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.110