DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and PRKG1

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens

Alignment Length:	349	Identity:	118/349 - (33%)
Similarity:	180/349 - (51%)	Gaps:	26/349 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 RSLQIHLSTLAREREQ--------ELELERQRE--REEQVKLDASRQVISP-------DDCEDLS 166
            |.||..|.....|..|        ||||:::.|  ::.|.:||..|.||.|       .....|.
Human     5 RDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQ 69

  Fly   167 PMPQTAAPPVRRRGGISAEPVT--EEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERS 229
            ..|:|      :|..|||||..  .:|.::......||..::.:.:.:||..|....:|:.|:..
Human    70 GEPRT------KRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQ 128

  Fly   230 DIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRA 294
            :|.|.|:||.:.....||::||.|...||::.|:|:|......:.|:..|..|||||::|...|.
Human   129 EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRT 193

  Fly   295 ATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFD 359
            |||:...:||||.|||..::.|:|.:.:.|...|.|||..|...:||.:.....:||.||...::
Human   194 ATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYE 258

  Fly   360 DGETIVKQGAAGDDFYIILEGCAVVLQQRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVA 424
            :||.|::|||.||.|:||.:|...|.::.| ..|||..:..||..|:|||.||..:..|.|.|:|
Human   259 NGEYIIRQGARGDTFFIISKGTVNVTREDS-PSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA 322

  Fly   425 RGPLKCVKLDRARFERVLGPCADI 448
            ...:.|:.:||..|:.::|...|:
Human   323 AEAVTCLVIDRDSFKHLIGGLDDV 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	47/125 (38%)
		CAP_ED	219..328	CDD:237999	39/108 (36%)
		Crp	331..>442	CDD:223736	42/110 (38%)
		CAP_ED	337..453	CDD:237999	41/112 (37%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	17/49 (35%)
		CAP_ED	118..227	CDD:237999	39/108 (36%)
		CAP_ED	237..341	CDD:237999	39/104 (38%)
		STKc_cGK	381..641	CDD:270724
		S_TK_X	636..>679	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810