Protein Alignment Pka-R1 and PRKAR1A

DIOPT Version :10

• Sequence 1: NP_001189150.1
• Gene: Pka-R1 / 40305
• FlyBaseID: FBgn0259243
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_002725.1
• Gene: PRKAR1A / 5573
• HGNCID: 9388
• Length: 381
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 257/403 - (63%)
• Similarity: 296/403 - (73%)
• Gaps: 38/403 - (9%)

  Fly    66 RILRESSIDGGVAMFDALLRDDHEHRLSLDAVHRMRHVRTSCTTIPEEDAVSDRSLQIHLSTLAR 130
            |.|||..:........|||:|.               :...||..||.             .:|.
Human    13 RSLRECELYVQKHNIQALLKDS---------------IVQLCTARPER-------------PMAF 49

  Fly   131 EREQELELERQREREEQVKLDASRQVISPDDCEDLSPMPQTAAPPV----RRRGGISAEPVTEED 191
            .||....||::..::.|....|..:..|.:|  ::||.|..   ||    ||||.||||..||||
Human    50 LREYFERLEKEEAKQIQNLQKAGTRTDSRED--EISPPPPN---PVVKGRRRRGAISAEVYTEED 109

  Fly   192 ATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNF 256
            |.:||:||:|||||||.||:|||.|||||:|||::||||||||||.|:.||||.:||||||||||
Human   110 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNF 174

  Fly   257 YVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGST 321
            ||||.||.||:||:|..|::.||||||||||||||||||||:|||:|||||||||||||||||||
Human   175 YVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGST 239

  Fly   322 IRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQ 386
            :|||||||||||:|||||||||||||||||:||...|:||:.||.||..||:|:|||||.|.|||
Human   240 LRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304

  Fly   387 QRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKR 451
            :||| .|:..||||||.||||||||||::||||||||||||||||||||.|||||||||:|||||
Human   305 RRSE-NEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKR 368

  Fly   452 NITQYNSFVSLSV 464
            ||.||||||||||
Human   369 NIQQYNSFVSLSV 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	CAP_ED	219..328	CDD:237999	88/108 (81%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)
PRKAR1A	NP_002725.1	Dimerization and phosphorylation	1..136		56/155 (36%)
		DD_RIalpha_PKA	14..63	CDD:438522	16/76 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..96		9/36 (25%)
		Pseudophosphorylation motif	96..100		3/3 (100%)
		CAP_ED	137..246	CDD:237999	88/108 (81%)
		CAP_ED	255..370	CDD:237999	90/115 (78%)