DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and pnpla7b

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_692276.5	Gene:	pnpla7b / 503936	ZFINID:	ZDB-GENE-050309-66	Length:	1340	Species:	Danio rerio

Alignment Length:	437	Identity:	83/437 - (18%)
Similarity:	156/437 - (35%)	Gaps:	87/437 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GRGGRILRESSIDGGVAMFDALLRDDHEHRLSLDAVHRMRHVRTSCTTIPEEDAVSDRSLQIHL- 125
            |||.|  |.|..:..|:  |.:.:...:|......:.|....:.:||..|.......|||...|
Zfish   339 GRGPR--RHSQTNEDVS--DKVPQRSSDHYSDTSHMSREDCGKLNCTESPTTLFRKSRSLSTPLE 399

  Fly   126 STLAREREQELELERQREREEQVKLDASRQVISPDDCEDLSPMPQTAAPPVRRRGGISAEPVTE- 189
            ||.|...:..:..:|..:.                     :|....|.....|:..::......
Zfish   400 STHAGSPDHNMTFDRSSKE---------------------APSSPIAIQKSNRKKSVTMHHSPSA 443

  Fly   190 ----EDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHI-AGENIIQQ 249
                .|...:...:   .:..:||:.:|..:::|  .:.:.:..::.:....:..: ||..:..:
Zfish   444 VFHYSDTGGHSSHI---HHSKVNAIFQAAKRDLL--KIIQLQDPNLLEDRVTLRQVKAGSVVASE 503

  Fly   250 GDEGDNFYVIDVGEVDVF---VNSE---LVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGI 308
            ||:..:...:..|.:.|:   ::.|   .:.....|...|.||::.|.|...:|||:.|.....|
Zfish   504 GDQDVSVQFVISGTLHVYQRLIDREEQSCLFVAHPGEMVGHLAVLTGEPLIFSVRAQRDCCFLSI 568

  Fly   309 DRDSYRRILMGSTIRKRKMYEEFLSRV-SILESLDKWERLTVADSLETCSFDDGETIVKQGAAGD 372
            .:..:..|:.........:....:.|| |.:..:|        .:|:..:.:.|..:.:||...|
Zfish   569 SKTHFYEIMRAEPRMVLNVAHTVVRRVSSFVRQID--------FALDWMALEAGRAVYRQGDKSD 625

  Fly   373 DFYIILEGCAVVLQQRSEQGEDPAE---VGRLGSSDYFGEIALLLDRPRAATVVA---------- 424
            ..:|:|.|     :.||...:|..:   .|..|..|..|.:..|....||.||.|
Zfish   626 STFIVLSG-----RLRSVIMKDDGKKELAGEYGRGDLIGVVEALTHLNRATTVHAVRDSELAKLP 685

  Fly   425 RGPLKCVK---------LDRARFERVLGPCADILKRNITQYNSFVSL 462
            .|.|..:|         |.....:::||        |:.|.|..:|:
Zfish   686 EGALNSIKRKYPQVVTRLIHLLGQKILG--------NMQQVNGPLSV 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	24/133 (18%)
		CAP_ED	219..328	CDD:237999	20/115 (17%)
		Crp	331..>442	CDD:223736	29/133 (22%)
		CAP_ED	337..453	CDD:237999	28/137 (20%)
pnpla7b	XP_692276.5	Crp	164..354	CDD:223736	7/18 (39%)
		CAP_ED	170..291	CDD:237999
		Crp	470..>602	CDD:223736	23/133 (17%)
		CAP_ED	473..583	CDD:237999	20/111 (18%)
		Crp	596..>718	CDD:223736	30/142 (21%)
		CAP_ED	596..704	CDD:237999	26/120 (22%)
		Pat_PNPLA6_PNPLA7	927..1232	CDD:132864
		RssA	932..1234	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900