DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and prkar1aa

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001009989.1	Gene:	prkar1aa / 494533	ZFINID:	ZDB-GENE-050116-2	Length:	379	Species:	Danio rerio

Alignment Length:	359	Identity:	254/359 - (70%)
Similarity:	286/359 - (79%)	Gaps:	18/359 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 CTTIPEEDAVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQVISPDDCED-LSPMPQ 170
            ||..||..           ....|:..::||||..::...|.| .:||.    |..|| :||...
Zfish    38 CTARPERP-----------MAYLRDYFEKLELEEAKQMVSQQK-SSSRS----DSREDEVSPPMN 86

  Fly   171 TAAPPVRRRGGISAEPVTEEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAM 235
            ......||||.||||..||||||:||:||:|||||||.||:|||.|||||||||::|||||||||
Zfish    87 PVVKGRRRRGAISAEVYTEEDATSYVRKVIPKDYKTMAALAKAIEKNVLFAHLDDNERSDIFDAM 151

  Fly   236 FPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAK 300
            |.|.:||||.:||||||||||||||.||:||:||:|.||:|.|||||||||||||||||||||||
Zfish   152 FSVTYIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWVTSIGEGGSFGELALIYGTPRAATVRAK 216

  Fly   301 TDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIV 365
            |:|||||||||||||||||||:|||||||||||:|||||||||||||||||:|||..|:||:.||
Zfish   217 TNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALETVQFEDGQKIV 281

  Fly   366 KQGAAGDDFYIILEGCAVVLQQRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLKC 430
            .||..||:|:|||||.|.|||:||| .|:..|||||..||||||||||::|||||||||||||||
Zfish   282 VQGQPGDEFFIILEGSAAVLQRRSE-NEEFVEVGRLAPSDYFGEIALLMNRPRAATVVARGPLKC 345

  Fly   431 VKLDRARFERVLGPCADILKRNITQYNSFVSLSV 464
            |||||.|||||||||:|||||||.||||||||||
Zfish   346 VKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	107/125 (86%)
		CAP_ED	219..328	CDD:237999	92/108 (85%)
		Crp	331..>442	CDD:223736	85/110 (77%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)
prkar1aa	NP_001009989.1	DD_RIalpha_PKA	14..62	CDD:213048	9/34 (26%)
		Crp	129..>255	CDD:223736	107/125 (86%)
		CAP_ED	135..244	CDD:237999	92/108 (85%)
		Crp	247..>357	CDD:223736	85/110 (77%)
		CAP_ED	253..368	CDD:237999	90/115 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4704
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37664
Inparanoid	1	1.050	546	1.000	Inparanoid score	I1122
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm25501
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	LDO	PTHR11635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870