DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and Prkg2

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_037144.1	Gene:	Prkg2 / 25523	RGDID:	3401	Length:	762	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	104/381 - (27%)
Similarity:	193/381 - (50%)	Gaps:	48/381 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 VSDRSLQIHLSTLARE-REQELELERQREREEQVKLDASRQVIS--------PDDCEDLSPM--- 168
            :|:.:|:..::.|.|| :.::.||:.:....::::...::|.::        ...|..|:.:
  Rat    21 LSNEALRSKVAELEREVKRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDV 85

  Fly   169 -------PQTAAP---PV-------------RRRG---GISAEPVTEEDATN------YVKKVVP 201
                   |..|:|   |:             .|||   |:||||.:.....|      :.|..|.
  Rat    86 IHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTSRTYDLNKPPEFSFEKARVR 150

  Fly   202 KDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDV 266
            ||......::.|:.||.....||..:..|:.:.|:..|:..|..|::||:.|::.:|:..|.::|
  Rat   151 KDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIVKQGEPGNHIFVLAEGRLEV 215

  Fly   267 FVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEF 331
            |...:|:::|....:|||||::|...|.|:|:|.|:||.|.:||:.::.|:..:...:.:.|..|
  Rat   216 FQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNF 280

  Fly   332 LSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSEQGED-P 395
            |..||:|::|.:.:...:.|.||...:|.|:.|:::|..|..|:|:.:|...|.|  |.:|.| |
  Rat   281 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQ--STEGHDQP 343

  Fly   396 AEVGRLGSSDYFGEIALLLDRPRAATVVA-RGPLKCVKLDRARFERVLGPCADILK 450
            ..:..|...:||||.||:.|..|:|.::| ...:.|:.:||..|.:.:|...::.|
  Rat   344 QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQK 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	41/125 (33%)
		CAP_ED	219..328	CDD:237999	33/108 (31%)
		Crp	331..>442	CDD:223736	38/112 (34%)
		CAP_ED	337..453	CDD:237999	36/116 (31%)
Prkg2	NP_037144.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..138		8/25 (32%)
		Crp	162..>285	CDD:223736	39/122 (32%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283		36/114 (32%)
		CAP_ED	168..273	CDD:237999	33/104 (32%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416		36/116 (31%)
		CAP_ED	286..401	CDD:237999	36/116 (31%)
		PTZ00263	417..752	CDD:140289
		STKc_cGK	459..718	CDD:270724
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810