Protein Alignment Pka-R1 and Prkar1b

DIOPT Version :10

• Sequence 1: NP_001189150.1
• Gene: Pka-R1 / 40305
• FlyBaseID: FBgn0259243
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_001405604.1
• Gene: Prkar1b / 25521
• RGDID: 3392
• Length: 381
• Species: Rattus norvegicus
• Alignment Length: 385
• Identity: 255/385 - (66%)
• Similarity: 296/385 - (76%)
• Gaps: 34/385 - (8%)

  Fly   106 SCTTIPEEDA-------VSDRSLQ-------IHLSTLAREREQELELERQREREEQVKLDASRQV 156
            ||....:||:       |....:|       :||.....:|    .|...||..|:::.:.:||:
  Rat     5 SCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPDR----PLRFLREHFEKLEKEENRQI 65

  Fly   157 I----SPDDC----EDLSPMPQTAAPPV----RRRGGISAEPVTEEDATNYVKKVVPKDYKTMNA 209
            :    |...|    |::||.|..   ||    |||||:|||..|||||.:||:||:|||||||.|
  Rat    66 LARQKSNSQCDSHDEEISPTPPN---PVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTA 127

  Fly   210 LSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVT 274
            |:|||:|||||:|||::||||||||||||.||.||.:||||:|||||||||.|||||:||.|.||
  Rat   128 LAKAISKNVLFSHLDDNERSDIFDAMFPVTHIDGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVT 192

  Fly   275 TISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILE 339
            .||||||||||||||||||||||:||||:||||||||||||||||||:|||||||||||:|||||
  Rat   193 NISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILE 257

  Fly   340 SLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSEQGEDPAEVGRLGSS 404
            ||:|||||||||:||...|:|||.||.||..|||||||.||.|.|||:|| ..|:..||||||.|
  Rat   258 SLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRS-PNEEYVEVGRLGPS 321

  Fly   405 DYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQYNSFVSLSV 464
            ||||||||||:||||||||||||||||||||.|||||||||::||||||.:||||:||:|
  Rat   322 DYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	CAP_ED	219..328	CDD:237999	92/108 (85%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)
Prkar1b	NP_001405604.1	Dimerization and phosphorylation	1..136		53/137 (39%)
		DD_RIbeta_PKA	10..64	CDD:438523	11/57 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..88		6/21 (29%)
		Pseudophosphorylation motif	96..100		3/3 (100%)
		CAP_ED	137..246	CDD:237999	92/108 (85%)
		CAP_ED	255..370	CDD:237999	90/115 (78%)