DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and Prkar1b

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_038945042.1	Gene:	Prkar1b / 25521	RGDID:	3392	Length:	381	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	255/385 - (66%)
Similarity:	296/385 - (76%)	Gaps:	34/385 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SCTTIPEEDA-------VSDRSLQ-------IHLSTLAREREQELELERQREREEQVKLDASRQV 156
            ||....:||:       |....:|       :||.....:|    .|...||..|:::.:.:||:
  Rat     5 SCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPDR----PLRFLREHFEKLEKEENRQI 65

  Fly   157 I----SPDDC----EDLSPMPQTAAPPV----RRRGGISAEPVTEEDATNYVKKVVPKDYKTMNA 209
            :    |...|    |::||.|..   ||    |||||:|||..|||||.:||:||:|||||||.|
  Rat    66 LARQKSNSQCDSHDEEISPTPPN---PVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTA 127

  Fly   210 LSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVT 274
            |:|||:|||||:|||::||||||||||||.||.||.:||||:|||||||||.|||||:||.|.||
  Rat   128 LAKAISKNVLFSHLDDNERSDIFDAMFPVTHIDGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVT 192

  Fly   275 TISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILE 339
            .||||||||||||||||||||||:||||:||||||||||||||||||:|||||||||||:|||||
  Rat   193 NISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILE 257

  Fly   340 SLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSEQGEDPAEVGRLGSS 404
            ||:|||||||||:||...|:|||.||.||..|||||||.||.|.|||:|| ..|:..||||||.|
  Rat   258 SLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRS-PNEEYVEVGRLGPS 321

  Fly   405 DYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQYNSFVSLSV 464
            ||||||||||:||||||||||||||||||||.|||||||||::||||||.:||||:||:|
  Rat   322 DYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	107/125 (86%)
		CAP_ED	219..328	CDD:237999	92/108 (85%)
		Crp	331..>442	CDD:223736	86/110 (78%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)
Prkar1b	XP_038945042.1	DD_RIbeta_PKA	11..64	CDD:213049	11/56 (20%)
		CAP_ED	137..246	CDD:237999	92/108 (85%)
		CAP_ED	255..370	CDD:237999	90/115 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354275
Domainoid	1	1.000	138	1.000	Domainoid score	I4721
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1144
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm45469
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	LDO	PTHR11635
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770