Protein Alignment Pka-R1 and Prkar1a

DIOPT Version :10

• Sequence 1: NP_001189150.1
• Gene: Pka-R1 / 40305
• FlyBaseID: FBgn0259243
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_068680.1
• Gene: Prkar1a / 19084
• MGIID: 104878
• Length: 381
• Species: Mus musculus
• Alignment Length: 403
• Identity: 257/403 - (63%)
• Similarity: 295/403 - (73%)
• Gaps: 38/403 - (9%)

  Fly    66 RILRESSIDGGVAMFDALLRDDHEHRLSLDAVHRMRHVRTSCTTIPEEDAVSDRSLQIHLSTLAR 130
            |.|||..:........|||:|.               :...|||.||..           ....|
Mouse    13 RSLRECELYVQKHNIQALLKDS---------------IVQLCTTRPERP-----------MAFLR 51

  Fly   131 EREQELELERQRE----REEQVKLDASRQVISPDDCEDLSPMPQTAAPPVRRRGGISAEPVTEED 191
            |..:.||.|..|:    ::..::.|:....|||       |.|.......||||.||||..||||
Mouse    52 EYFERLEKEEARQIQCLQKTGIRTDSREDEISP-------PPPNPVVKGRRRRGAISAEVYTEED 109

  Fly   192 ATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNF 256
            |.:||:||:|||||||.||:|||.|||||:|||::||||||||||||:.||||.:||||||||||
Mouse   110 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNF 174

  Fly   257 YVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGST 321
            ||||.||:||:||:|..|::.||||||||||||||||||||:|||:|||||||||||||||||||
Mouse   175 YVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGST 239

  Fly   322 IRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQ 386
            :|||||||||||:|||||||||||||||||:||...|:||:.||.||..||:|:|||||.|.|||
Mouse   240 LRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQ 304

  Fly   387 QRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKR 451
            :||| .|:..||||||.||||||||||::||||||||||||||||||||.|||||||||:|||||
Mouse   305 RRSE-NEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKR 368

  Fly   452 NITQYNSFVSLSV 464
            ||.||||||||||
Mouse   369 NIQQYNSFVSLSV 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	CAP_ED	219..328	CDD:237999	89/108 (82%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)
Prkar1a	NP_068680.1	Dimerization and phosphorylation	2..136		55/155 (35%)
		DD_RIalpha_PKA	14..63	CDD:438522	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..96		6/29 (21%)
		Pseudophosphorylation motif	96..100		3/3 (100%)
		CAP_ED	137..246	CDD:237999	89/108 (82%)
		CAP_ED	255..370	CDD:237999	90/115 (78%)