DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-R1 and prkar2a

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_002933104.1	Gene:	prkar2a / 100486265	XenbaseID:	XB-GENE-982783	Length:	404	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	131/358 - (36%)
Similarity:	199/358 - (55%)	Gaps:	31/358 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EDAVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQVISPDDCEDLSPMPQTAAPPV- 176
            :|.....||:.|...:..:.| .::.|...:.||..:         .||..|..       |||
Frog    45 QDGAGAGSLRPHARVVNFDGE-PMQTESNGDEEEDEE---------DDDDSDFE-------PPVI 92

  Fly   177 ---RRRGGISAEPVT--EEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMF 236
               .||..:.||...  |||.....:.|.||..:....|.:|....:||.:||:.:.|.:.||||
Frog    93 NRYSRRVSVCAEAYNPDEEDEDTEPRVVRPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMF 157

  Fly   237 PVNHIAGENIIQQGDEGDNFYVIDVGEVDVFV----NSELVTTISEGGSFGELALIYGTPRAATV 297
            .:.....|::|.|||:||||||::.|:.|:||    .|..|......||||||||:|.||||||:
Frog   158 EMRVKPQEHVIDQGDDGDNFYVVERGQYDIFVERDGQSRCVGRYDNHGSFGELALMYNTPRAATI 222

  Fly   298 RAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGE 362
            .|.::..|||:||.::|||::.:..:|||.||.|:..|.:|:.|:..||:.:.|.:....:.||:
Frog   223 VATSEGALWGLDRVTFRRIILKNNAKKRKTYEIFIESVPVLKFLELSERMKIVDVIAARVYKDGD 287

  Fly   363 TIVKQGAAGDDFYIILEG-CAVVLQQRSEQGED---PAEVGRLGSSDYFGEIALLLDRPRAATVV 423
            .|:.||...|.|:|:..| ..::::.:::.|::   ..|:.|..|..||||:||:.::||||:..
Frog   288 RIIAQGDKADCFFIVESGEVKIMMKSKTKTGQESNQEVEIARCKSGQYFGELALVTNKPRAASAY 352

  Fly   424 ARGPLKCVKLDRARFERVLGPCADILKRNITQY 456
            |.|.:||:.:|...|||:||||.||:|||||.|
Frog   353 AVGDVKCLIMDVQAFERLLGPCMDIMKRNITHY 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	58/129 (45%)
		CAP_ED	219..328	CDD:237999	53/112 (47%)
		Crp	331..>442	CDD:223736	38/114 (33%)
		CAP_ED	337..453	CDD:237999	44/119 (37%)
prkar2a	XP_002933104.1	DD_RIIalpha_PKA	3..43	CDD:213050
		CAP_ED	140..253	CDD:237999	53/112 (47%)
		CAP_ED	262..382	CDD:237999	44/119 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960