DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R1 and prkg2

DIOPT Version :9

Sequence 1:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_021331649.1	Gene:	prkg2 / 100125912	ZFINID:	ZDB-GENE-060531-80	Length:	769	Species:	Danio rerio

Alignment Length:	393	Identity:	106/393 - (26%)
Similarity:	196/393 - (49%)	Gaps:	56/393 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 IPEEDAVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQVISP------DDCEDL--- 165
            :|:...|....|:.||    ::::::|..:..:.:..:.:|...:|.:|.      ..|..|
Zfish    29 VPQVLRVRVEELETHL----KKKDEDLNAKELQIKHLEEQLAQQKQTLSEISDTLRSKCLQLNKL 89

  Fly   166 --------------SPMPQTAAPPV---------RRRG---GISAEPVTEEDATNYVKKVVPKDY 204
                          ||:.:..:..:         ||:|   |:||||    .:..|....:||.|
Zfish    90 QDALKSQGELGLLPSPLKEKVSQGLTGLLRETLNRRKGAKAGVSAEP----SSRTYDSSGIPKFY 150

  Fly   205 ----------KTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVI 259
                      .....|:.|:.||.....|:..:..|:.:.|:...:..||.:|:||:.|::.:|:
Zfish   151 FESARVWKEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVL 215

  Fly   260 DVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRK 324
            ..|::||:.:::|:|:|:...:|||||::|...|.|:|:|.::||.|.:||:.:..|:..:...:
Zfish   216 ADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEAR 280

  Fly   325 RKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRS 389
            .:.|..||..||:|.||...:...:.|.||...::.|:.|:::|..|:.||||..| .:.:.|.:
Zfish   281 HEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANG-KIKVTQST 344

  Fly   390 EQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVA-RGPLKCVKLDRARFERVLGPCADILKRNI 453
            :..|:|..:..||..|||||.||:.|..|:|.::| ...::|:.:||..|.:.:| ..|.||:.:
Zfish   345 QDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVG-TFDELKKYL 408

  Fly   454 TQY 456
            ..|
Zfish   409 QSY 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	40/125 (32%)
		CAP_ED	219..328	CDD:237999	32/108 (30%)
		Crp	331..>442	CDD:223736	39/111 (35%)
		CAP_ED	337..453	CDD:237999	39/116 (34%)
prkg2	XP_021331649.1	CAP_ED	176..284	CDD:237999	32/107 (30%)
		CAP_ED	293..408	CDD:237999	39/116 (34%)
		STKc_cGK	466..725	CDD:270724
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810