Protein Alignment HIPP1 and Hadha

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_849209.1
• Gene: Hadha / 97212
• MGIID: 2135593
• Length: 763
• Species: Mus musculus
• Alignment Length: 720
• Identity: 140/720 - (19%)
• Similarity: 242/720 - (33%)
• Gaps: 238/720 - (33%)

  Fly   320 HSPNSAI-LLNNKISG--VKVMLKTVSQKQLAASTGAAAEKTKPTVVV-----------SPPKET 370
            :||||.: .||.::..  ::||.:..:..|:.:   |....:||...|           :.|:|.
Mouse    55 NSPNSKVNTLNKEVQSEFIEVMNEIWANDQIRS---AVLISSKPGCFVAGADINMLSSCTTPQEA 116

  Fly   371 EEHTTGFKRMRVIKRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTT---TKKE 432
            ...:...:||            ..:.:||                ||..|.:||.:..   .:..
Mouse   117 TRISQEGQRM------------FEKLEKS----------------PKPVVAAISGSCLGGGLELA 153

  Fly   433 VAPKKRSATPTARSTKAGTP---------VGGTERGPSPVKRRA--QTPNTGLANGGTQKKKKVS 486
            :|.:.|.||.. |.|..|.|         .|||:|.|..|...|  ....|| .|....:.||:.
Mouse   154 IACQYRIATKD-RKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTG-RNIRADRAKKMG 216

  Fly   487 EIDRLMG-----------------DEGAANMIHAVEHEQRELSGGEVSNKPLMRK---RAMTITG 531
            .:|:|:.                 :|.|.|....:  ..|::|..:  :|.|:.|   .|||:..
Mouse   217 LVDQLVEPLGPGIKSPEERTIEYLEEVAVNFAKGL--ADRKVSAKQ--SKGLVEKLTTYAMTVPF 277

  Fly   532 RNQAARVAVEPTPPKKESAQSAAKRTPADSVFTKATANTSARKPRASDSWDYVYKQRASE----- 591
            ..|.....||....|:......|.....|:|        .|...:.||:......|:..|
Mouse   278 VRQQVYKTVEEKVKKQTKGLYPAPLKIIDAV--------KAGLEQGSDAGYLAESQKFGELALTK 334

  Fly   592 ES----------MIMRRRSNSSYSSN-------------ASVSRNSLDNRPGAANLSDDA----- 628
            ||          ::.::....:...|             |.:::.|:|.  |...|..|.
Mouse   335 ESKALMGLYNGQVLCKKNKFGAPQKNVQQLAILGAGLMGAGIAQVSVDK--GLKTLLKDTTVTGL 397

  Fly   629 GEGSDPSFK-------------------FVKPVSKSSQRGGEDTS------------SHTLANDM 662
            |.|....||                   |...:.:...:|.|...            .|.:..::
Mouse   398 GRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLGVKHKVLKEV 462

  Fly   663 K---------ANNGSELVCLHKVNKVAHLVIHTERGNFGHTYS----KQLLEQL-------NDTL 707
            :         |:|.|.|    .:|::|.:....|:....|.:|    .||||.:       :.|.
Mouse   463 ESVTPEHCIFASNTSAL----PINQIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTA 523

  Fly   708 SSVA---RKGEFNTVLLTVEGPQF----CQG---IDCQELIQGSLEKRKDSASQLAVALKCYLRT 762
            |:||   |:|:  .:::..:||.|    |..   .:...::|..::.:|             |..
Mouse   524 SAVAVGLRQGK--VIIVVKDGPGFYTTRCLAPMMSEVMRILQEGVDPKK-------------LDA 573

  Fly   763 LAT-FPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSE 826
            |.| |..|:.|..:..::.:.|.|      .||.|          ||: ..|.....|...:..:
Mouse   574 LTTGFGFPVGAATLADEVGVDVAQ------HVAED----------LGK-AFGERFGGGSVELLKQ 621

  Fly   827 VHSRLFL---MGERLF----ATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKL 884
            :.|:.||   .|:..:    .::....||.:|.|     :..:.|....::|:.....||.:.:.
Mouse   622 MVSKGFLGRKSGKGFYIYQEGSKNKSLNSEMDNI-----LANLRLPAKPEVSSDEDVQYRVITRF 681

  Fly   885 NHSAV 889
            .:.||
Mouse   682 VNEAV 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628	66/307 (21%)
		crotonase-like	673..870	CDD:119339	45/225 (20%)
Hadha	NP_849209.1	fa_ox_alpha_mit	27..762	CDD:131494	140/720 (19%)