Protein Alignment HIPP1 and CDYL

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001355054.1
• Gene: CDYL / 9425
• HGNCID: 1811
• Length: 598
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 139/753 - (18%)
• Similarity: 254/753 - (33%)
• Gaps: 236/753 - (31%)

  Fly   208 ASPKVPASKPIKSNSLPSISKHKLSPEQARAVALEQMAGLKPKSRRKEPPAPPSVVAPIDIVSSL 272
            ::|..|:...|      |:|..:...:|..|:.:|::.     .:||........:.
Human    36 SAPDGPSDPSI------SVSSEQSGAQQPPALQVERIV-----DKRKNKKGKTEYLV-------- 81

  Fly   273 NDDWDDYDSEEDKSASALVTEVITLPSAHVV-------------TKKPPLPVKKLSSPVKHSPNS 324
              .|..||||:|...          |..|:|             |:|.  ....|:...:.|||:
Human    82 --RWKGYDSEDDTWE----------PEQHLVNCEEYIHDFNRRHTEKQ--KESTLTRTNRTSPNN 132

  Fly   325 AILLNNKISGVKVMLKTVSQKQLAASTGAAAEKTKPTVVVSPPKETEEHTTGFKRMRVIKRKIIW 389
            |                  :||::.||.:...||.|..:|.    .::|
Human   133 A------------------RKQISRSTNSNFSKTSPKALVI----GKDH---------------- 159

  Fly   390 DPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTKAGTPVG 454
                 |:|.|....||.|..           |:.:|:.:::|.:...|       ...|...|
Human   160 -----ESKNSQLFAASQKFR-----------KNTAPSLSSRKNMDLAK-------SGIKILVP-- 199

  Fly   455 GTERGPSPVKRRAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANMIHAVEHEQRELSGGEV-SN 518
                 .||||.|  |...|..:...:|                   :..||..|.:....|| :.
Human   200 -----KSPVKSR--TAVDGFQSESPEK-------------------LDPVEQGQEDTVAPEVAAE 238

  Fly   519 KPLMRKRAMTITGRNQA---ARVAVEPTPPKKESAQSAAKRT-------------------PADS 561
            ||:   .|:...|..:|   :|..:.|..|:.....:||..|                   ...:
Human   239 KPV---GALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLAVNGKGTSPFMDALTANGTTN 300

  Fly   562 VFTKATANTSARKPRASDSWDYVYKQRASEESMIMR---RRSNSSYSSNASVSRNSLDNRPGAAN 623
            :.|..|..|::::....|..|..:.:|       :|   |::.|:|.....|.|.
Human   301 IQTSVTGVTASKRKFIDDRRDQPFDKR-------LRFSVRQTESAYRYRDIVVRK---------- 348

  Fly   624 LSDDAGEGSDPSFKFVKPVSKSSQRGGEDTSSHTLANDMKANNGSELVCLHKVNKVAHLVIHTER 688
                                       :|..:|.|.:...:.|.|
Human   349 ---------------------------QDGFTHILLSTKSSENNS-------------------- 366

  Fly   689 GNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLA 753
                  .:.:::.::...||:.| ..:...|||:..|..||.|:|....|:...:.||..::::|
Human   367 ------LNPEVMREVQSALSTAA-ADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMA 424

  Fly   754 VALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWH 818
            .|::.::.|...|.||::..:.|..|.||...||..|.|.|::...|:|.|...||.|:|.:...
Human   425 EAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVM 489

  Fly   819 GHQRVSSEVHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKK 883
            ..:.:.....:.:.|.|.:|.|.|.. ....|.::.......:..:.:.|::::.:..:....|.
Human   490 FPKIMGGASANEMLLSGRKLTAQEAC-GKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKA 553

  Fly   884 LNHSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYL 921
            |....:.:......:.|.:|:.:.|.:|..:.:..:||
Human   554 LVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628	74/407 (18%)
		crotonase-like	673..870	CDD:119339	43/196 (22%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		10/50 (20%)
		Interaction with EZH2. /evidence=ECO:0000269|PubMed:22009739	61..309		66/366 (18%)
		CD_CDY	62..111	CDD:349284	12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..149		12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..226		7/42 (17%)
		crotonase-like	344..540	CDD:119339	50/260 (19%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594		53/258 (21%)