Protein Alignment HIPP1 and HIPP1

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: XP_001688070.2
• Gene: HIPP1 / 5666915
• VectorBaseID: AGAMI1_002546
• Length: 1153
• Species: Anopheles gambiae
• Alignment Length: 1188
• Identity: 292/1188 - (24%)
• Similarity: 450/1188 - (37%)
• Gaps: 361/1188 - (30%)

  Fly     4 VSDSAVTTLESTQ-AEEPPPGVEKVETLELK--------TAALETLSESAGPTDLENELANLNGS 59
            :||....||.:.: |.:|..||.|      |        ||..:.||......||...:.:...|
Mosquito    53 LSDDETKTLTTLEPARKPSGGVAK------KSFPGAAGATAVSQKLSNEPPKNDLSTPVKSKTSS 111

  Fly    60 E--EGPGLDEL-----STLEREIAKLHNIRPPDAASEVKDSDTPIALADNGGLEPRQAPDEAKCR 117
            .  |.|..|.|     |.|.:.| :|.:|.|...|...    :|:.|..:|.:|   .|.:....
Mosquito   112 SATEQPSADSLIQKMRSKLSKHI-ELKSINPAKPAKPA----SPVPLDMSGAIE---IPQDMILS 168

  Fly   118 TPIIEEGNAASGNGQSSESPLEEVDLIALLKGTDTSHDQPTGE-EKCTLEKALSELDGVGEDGDV 181
            ..|.:...|||   .:.||.|::.||||:|:|......:...| |.|                ||
Mosquito   169 NDIPQTPIAAS---DAKESRLDDHDLIAILEGNMVEIRENASEIEVC----------------DV 214

  Fly   182 GVTIEGEGQFEIMEIDDDEGESSSR---------KASPKVPASKPIKSNSLPSISKHKLSPEQAR 237
            |.::| ...|.|::.|..:.|...|         ::.|.:|..:..::.::|..|. .:||..::
Mosquito   215 GASLE-IVSFSIIDPDQLQQEKKEREMEIARRQMESLPLLPKVRKPRTKTVPKRSP-TVSPAASQ 277

  Fly   238 AVALEQMAGLKPKSRRKEPPAPPSVVAPIDIVSSLNDDWDDYDSEEDKSASALVTEVITLPSAHV 302
            .|.:|  |.:.|      ||.||.|..||.:..               .....:..|:.:||..:
Mosquito   278 GVPVE--ANVTP------PPPPPVVKEPIGVTI---------------KGQTTIRPVVKIPSGAI 319

  Fly   303 -------------------------VTKKPPLPV----KKLS--SPVKHSPNS-AILLNNKIS-- 333
                                     :.|:...||    |.||  .||..||.: :.|:::.:|
Mosquito   320 KKEETAPSETAETIKARISKNLKEKLMKEMKFPVQTVEKPLSKVEPVTVSPQTKSELVDSLVSDW 384

  Fly   334 ----------GVKVMLKTVSQKQLAASTGAA-------AEKTKPTVVVSPPKETEEHTTGFKRMR 381
                      ||....:|..:..||.|...|       ..|::||..|:||...|.       .|
Mosquito   385 DDDPPVQQQDGVDDPQETEKKPVLAPSNDEAKVPQQQQQPKSQPTQFVAPPPIAEP-------KR 442

  Fly   382 VIKRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARS 446
            ||||||||||              :.|:.|..:..|:.....:.||.|:.....:||:.:...|.
Mosquito   443 VIKRKIIWDP--------------SDASIPFASLVKSNRAQSAGTTNTELSPLRRKRADSVAVRM 493

  Fly   447 TKAGTPVGGTERGP-----SPVKRRAQTPNTG--------------LANGGTQKKKKVSEIDRLM 492
                     .:..|     :||:.||:||:.|              |||....||:|.:||:||:
Mosquito   494 ---------IDNAPHFSTVAPVRPRAKTPDLGQAIERSALAAKPDELANDAKAKKRKKNEIERLL 549

  Fly   493 GDEGAANMIHAVEHE--------QRELSGGEVSNKPLMRKRAMT--------------------- 528
            |||||.||::.||.|        :.|:...:...|.|.:.:.:|
Mosquito   550 GDEGAINMLYDVECEATRKDLLKETEVDTSDEDEKLLAKTKIITDAVINQGKSPNESPTSQGLRV 614

  Fly   529 -----ITGRNQAARVAVEP-------------TPPKKESAQSAA----KRTPADSVFTKAT---A 568
                 .|..||:...|..|             .|....||..|.    .:.||:...|..|   |
Mosquito   615 RAKRGTTPSNQSGSTATSPGSAGTAQQTSKASVPSATSSASGAGGNQPSKKPANGKATTTTTIPA 679

  Fly   569 NTSARKPR----ASDSWDYVYKQRASEESMIMRRRSNSSYSS-NASVSRNSLD--NRPG------ 620
            .|.|||.:    |:..|:|||....|:::||:|||||||||| .||..|.|.|  |..|
Mosquito   680 ITGARKRKMTASAAKEWEYVYNAPRSDDAMIIRRRSNSSYSSGGASPRRLSFDQPNESGSGFGSE 744

  Fly   621 AANLSDDAGEGSDPSF-------KFVKPVSKSSQR--------------GGED------------ 652
            ::.||.:....:..||       .|:||.:|...:              |.||
Mosquito   745 SSTLSQNGTNNNKSSFPGQQQQDAFLKPPNKKEPKLPVTKPPGGAGGSTGSEDIKFNPSLVANMR 809

  Fly   653 --------------TSSHTLANDMKA-----------------------------------NNGS 668
                          .::.|...|:.|                                   ..||
Mosquito   810 GKLSKVLKGMKGAPLATSTPGQDVPAQANKQAAKRKAPASSVDVVDSAVSAAVGDVVSPPGGGGS 874

  Fly   669 --------------ELVCLHKVNKVAHLVIHT--------ERGNFGHTYSKQLLEQLNDTLSSVA 711
                          ::.|: |....|.:|:.:        .:|...:.:|::|:.:|:.|..::.
Mosquito   875 FQDAAVQKQLDQLKQMTCV-KQGNYAEIVMKSRSVTSGDGSKGPLENVFSQELMNELHTTFLALQ 938

  Fly   712 RKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIVG 776
            :......|||...|..|.:|:|...|:| .:||||.:|.:::..|..:|:.|..||||:||.:.|
Mosquito   939 KDVSVRAVLLRSGGAHFSRGLDVAHLVQ-PVEKRKAAAEEMSTCLMKFLKMLVAFPKPIVAAVQG 1002

  Fly   777 SQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGY-ALWHGHQRVSSEVHSRLFLMGERLFA 840
            ..:.:||..||..|.|:|....||...|...|.|||.. |...|.:.:.::..:.|||.|:||.|
Mosquito  1003 DVLGMGVTILPLFDVVIAQLGSSFVAPYGHFGYLPEALGAFSSGVRSLKAKTTTDLFLQGKRLTA 1067

  Fly   841 TELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKK-LNHSAVNVTKFPRLDEELKVI 904
            ...|: ...|.:...|....|.|...||.:::.|.:...::|: |....|...:...|.|: |..
Mosquito  1068 AAALD-YGLVTETVPAERFEERARTVAKSVASQSIQAMLSIKQHLRRELVTKMESALLLEQ-KKH 1130

  Fly   905 GEQWVTADCLANFKRYLN 922
            .:||.|.:|.|.||.:::
Mosquito  1131 AQQWTTPECQAKFKLFVS 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628	130/569 (23%)
		crotonase-like	673..870	CDD:119339	62/205 (30%)
HIPP1	XP_001688070.2	None