Protein Alignment HIPP1 and ECHDC1

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001132982.1
• Gene: ECHDC1 / 55862
• HGNCID: 21489
• Length: 307
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 73/332 - (21%)
• Similarity: 130/332 - (39%)
• Gaps: 59/332 - (17%)

  Fly   594 MIMRRRSNSSYSSNASVS-RNSLDNRPGAANLSDDAGEGSDPSFKFVKPVSKSSQR--GGEDTSS 655
            |.:::....|....||:| |..|.::.|.:..|...|       .:.:.|.|:.|:  ||.
Human     1 MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHG-------FYEEEVKKTLQQFPGGS---- 54

  Fly   656 HTLANDMKANNGSELVCLHKVNKVAHLVIHTERGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVL 720
               .:..|.:||..::.|:..:::         ..|......||||::.:..:....||
Human    55 ---IDLQKEDNGIGILTLNNPSRM---------NAFSGVMMLQLLEKVIELENWTEGKG------ 101

  Fly   721 LTVEGPQ--FCQGIDCQELIQGSLEKRKDSASQLAVALKCYLR-TLATFPK-PL--VAGIVGSQI 779
            |.|.|.:  |..|.|...:  .||...:|.   :||.:  ::: ||..|.: ||  ||.:.|..:
Human   102 LIVRGAKNTFSSGSDLNAV--KSLGTPEDG---MAVCM--FMQNTLTRFMRLPLISVALVQGWAL 159

  Fly   780 NLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLFLMGERLFATELL 844
            ..|.......|:.:.:.:......:.::|.:|.    |.|..|:...:.||..|  :.|.....|
Human   160 GGGAEFTTACDFRLMTPESKIRFVHKEMGIIPS----WGGTTRLVEIIGSRQAL--KVLSGALKL 218

  Fly   845 ESNS-----FVDKICKARNVN---EMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEEL 901
            :|.:     .|:::.::.:..   |.|....||......|:.|.|||...|...:.....|..|.
Human   219 DSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNER 283

  Fly   902 KVIGEQW 908
            .::|..|
Human   284 DLLGTVW 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628
		crotonase-like	673..870	CDD:119339	44/210 (21%)
ECHDC1	NP_001132982.1	CaiD	61..300	CDD:440647	57/258 (22%)