Protein Alignment HIPP1 and CDY2B

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001001722.1
• Gene: CDY2B / 203611
• HGNCID: 23921
• Length: 541
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 113/567 - (19%)
• Similarity: 206/567 - (36%)
• Gaps: 85/567 - (14%)

  Fly   384 KRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTK 448
            |:...|:|:         |:......|......:.|.|....|.||...:. ...:...|:||||
Human    33 KQDDTWEPE---------QHLMNCEKCVHDFNRRQTEKQKKLTWTTTSRIF-SNNARRRTSRSTK 87

  Fly   449 AGTPVGGTERGPSPVKRRAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANMIHAVEHEQRELSG 513
            |...           |...:||.|.                               :|.:.:...
Human    88 ANYS-----------KNSPKTPVTD-------------------------------KHHRSKNCK 110

  Fly   514 GEVSNKPLMRKRAMTI--TGRNQAARVAVEPTPP------KK--ESAQSAAKRTP-----ADSVF 563
            ...::|.:.||.|.|:  |...:.....:|...|      ||  ...|...|..|     .|:|.
Human   111 LFAASKNVRRKAASTLSDTKNMEIINSTIETLAPDSPFDHKKTVSGFQKLEKLDPIAADQQDTVV 175

  Fly   564 TKATANTSARKPRASDSWDYVYKQRASEESMIMRRRSNSSYSSNASVSRNSLDNRPGAANLSDDA 628
            .|.|.....|.|.:....:....|..::...:|.:.|.|..:|.|:.|.    .|.|...|.|..
Human   176 FKVTEGKLLRDPLSHPGAEQTGIQNKTQMHPLMSQMSGSVTASMATGSA----TRKGIVVLIDPL 236

  Fly   629 GEGSDPSFKFVKPVSKSSQRGGEDTS---------SHTLANDMKANNGSELVCLHKVNKVAHLVI 684
            ............|..|..||...|.|         ..|:.....|....::| :.|.:....:|:
Human   237 AANGTTDMHTSVPRVKGGQRNITDDSRGQPFIKKMHFTIRLTESAITYRDIV-VKKEDGFTQIVL 300

  Fly   685 HTERGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSA 749
            .| |....:..:.::::::.:.|:|.| ..:...||.:..|..||.|:|....::.....|..::
Human   301 ST-RSTEKNALNTEVIKEMVNALNSAA-ADDSKLVLFSAAGSVFCCGLDFGYFVRHLRNDRNTAS 363

  Fly   750 SQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGY 814
            .::...:|.::.|...|.||:|..:.|..|.||...||..|.|.|::...|:|.|...||.|:|.
Human   364 LEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGC 428

  Fly   815 ALWHGHQRVSSEVHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYR 879
            :.....:.:.....:.:.:.|.:|.|.|.. :...|.::.......:..:.:.|::::.:|.:..
Human   429 SSITFPKMMGKASANEMLIAGRKLTAREAC-AKGLVSQVFLTGTFTQEVMIQIKELASYNAIVLE 492

  Fly   880 TLKKLNHSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYL-NDVD 925
            ..|.|....:.:......:.|.:|:.:.|.:|..:.:..:|: |.:|
Human   493 ECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENKID 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628	40/210 (19%)
		crotonase-like	673..870	CDD:119339	43/196 (22%)
CDY2B	NP_001001722.1	CD_CDY	5..56	CDD:349284	5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..104		10/74 (14%)
		crotonase-like	287..483	CDD:119339	44/199 (22%)