Protein Alignment HIPP1 and Cdyl

DIOPT Version :10

• Sequence 1: NP_649261.1
• Gene: HIPP1 / 40302
• FlyBaseID: FBgn0037027
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_034011.1
• Gene: Cdyl / 12593
• MGIID: 1339956
• Length: 593
• Species: Mus musculus
• Alignment Length: 751
• Identity: 141/751 - (18%)
• Similarity: 257/751 - (34%)
• Gaps: 219/751 - (29%)

  Fly   221 NSLPSISKHKLS--PEQARAVALE---QMAGLKPKSRRKEPPAPPSVVAPIDIVSSLNDD----- 275
            ||.|:..:.:|.  ||:|.....:   |...:.|.:..:...|.|::......|.|:.|.
Mouse     5 NSQPNSQEAQLCTLPEKAEQPTDDNTCQQNNVVPATVSEPDQASPAIQDAETQVESIVDKRKNKK 69

  Fly   276 --------WDDYDSEEDKSASALVTEVITLPSAHVVTKKPPL-----------PVKKLSSPVKHS 321
                    |..||||:|...          |..|:|..:..:           ....|:...:.|
Mouse    70 GKTEYLVRWKGYDSEDDTWE----------PEQHLVNCEEYIHDFNRRHNERQKEGSLARASRAS 124

  Fly   322 PNSAILLNNKISGVKVMLKTVSQKQLAASTGAAAEKTKPTVVVSPPKETEEHTTGFKRMRVIKRK 386
            |::|                  :||::.||.:...||....:|    ..::|
Mouse   125 PSNA------------------RKQISRSTHSTLSKTNSKALV----VGKDH------------- 154

  Fly   387 IIWDPDVPETKKSFAQYASTK-AACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTKAG 450
                    |:|.|....||.| ...|||:....  |::....:..|.:.||.        ..|..
Mouse   155 --------ESKSSQLLAASQKFRKNPAPSLANR--KNMDLAKSGIKILVPKS--------PVKGR 201

  Fly   451 TPVGGTERGPSPVKR---------------RAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANM 500
            |.|.|.: |.||.|.               .|:.|...|...|.::.:.           |:...
Mouse   202 TSVDGFQ-GESPEKLDPVDQGAEDTVAPEVTAEKPTGALLGPGAERARM-----------GSRPR 254

  Fly   501 IHAVEHEQRELSGGEVSNKPLMRKRAMTITGRNQAARVAV--EPTPPKKESAQSAAKRTPADSVF 563
            ||                 ||:.:.:..:|.. .|..:||  :.|.|..::.  ||..|.  ::.
Mouse   255 IH-----------------PLVPQVSGPVTAA-MATGLAVNGKGTSPFMDAL--AANGTV--TIQ 297

  Fly   564 TKATANTSARKPRASDSWDYVYKQRASEESMIMR---RRSNSSYSSNASVSRNSLDNRPGAANLS 625
            |..|..|:.::....|..|..:.:|       :|   |::.|:|.....|.|.
Mouse   298 TSVTGVTAGKRKFIDDRRDQPFDKR-------LRFSVRQTESAYRYRDIVVRK------------ 343

  Fly   626 DDAGEGSDPSFKFVKPVSKSSQRGGEDTSSHTLANDMKANNGSELVCLHKVNKVAHLVIHTERGN 690
                                     :|..:|.|.:...:.|.|
Mouse   344 -------------------------QDGFTHILLSTKSSENNS---------------------- 361

  Fly   691 FGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVA 755
                .:.::::::...||:.| ..:...|||:..|..||.|:|....|:...:.||..::::|.|
Mouse   362 ----LNPEVMKEVQSALSTAA-ADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMADA 421

  Fly   756 LKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGH 820
            ::.::.|...|.||::..:.|..|.||...||..|.|.|::...|:|.|...||.|:|.:.....
Mouse   422 IRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFP 486

  Fly   821 QRVSSEVHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLN 885
            :.:.....:.:...|.:|.|.|.. ....|.::.......:..:.:.|::::.:..:....|.|.
Mouse   487 KIMGGASANEMLFSGRKLTAQEAC-GKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALV 550

  Fly   886 HSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYL 921
            ...:.:......:.|.:|:.:.|.:|..:.:..:||
Mouse   551 RCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYL 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	PTZ00449	<148..580	CDD:185628	77/405 (19%)
		crotonase-like	673..870	CDD:119339	42/196 (21%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		7/24 (29%)
		Interaction with EZH2. /evidence=ECO:0000250|UniProtKB:Q9Y232	56..304		65/344 (19%)
		CD_CDY	57..106	CDD:349284	12/58 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..158		13/90 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..223		7/23 (30%)
		crotonase-like	339..535	CDD:119339	49/260 (19%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		52/258 (20%)