DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tzn and GLO2

DIOPT Version :9

Sequence 1:	NP_730568.1	Gene:	tzn / 40299	FlyBaseID:	FBgn0037024	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_010558.3	Gene:	GLO2 / 851865	SGDID:	S000002680	Length:	274	Species:	Saccharomyces cerevisiae

Alignment Length:	265	Identity:	93/265 - (35%)
Similarity:	151/265 - (56%)	Gaps:	29/265 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NYMYLIVDTKTREAAVVDPVE-PELVIKTVQEQQLTLSKVLTTHHHWDHAGGNEKLLK-LWEK-- 161
            ||.||:.|:|.:::.::||.| ||::.:..:::::::..::.||||:|||.||..:|| |.||
Yeast    16 NYCYLLSDSKNKKSWLIDPAEPPEVLPELTEDEKISVEAIVNTHHHYDHADGNADILKYLKEKNP 80

  Fly   162 --ELDVYGGD---DRIGALNKKVQQDDTFTIGGLHVKCLSTPCHTTGHICYHITAQQGSGEGAVF 221
              :::|.||.   .::..:.:.:::   ..:|.|.:.|:.|||||...|||:: ....:.|..:|
Yeast    81 TSKVEVIGGSKDCPKVTIIPENLKK---LHLGDLEITCIRTPCHTRDSICYYV-KDPTTDERCIF 141

  Fly   222 TGDTLFQGGCGRFFEGTPEEMYEALCTKLSALP-----DATKVFCGHEYTLQNMSFARHVEP--- 278
            ||||||..|||||||||.|||..||...:....     ..|:|:.|||||..|:.|.|.:.|
Yeast   142 TGDTLFTAGCGRFFEGTGEEMDIALNNSILETVGRQNWSKTRVYPGHEYTSDNVKFVRKIYPQVG 206

  Fly   279 DNEVIQQRIEW-AKHRRASQDPTVPSTIGEEKSWNPFMRVHEATVQKHAG---GATDPVVTMGKL 339
            :|:.:.:..:: :||...:.    ..|:.:|..:|||||:.:..|||.||   .:.|....|.||
Yeast   207 ENKALDELEQFCSKHEVTAG----RFTLKDEVEFNPFMRLEDPKVQKAAGDTNNSWDRAQIMDKL 267

  Fly   340 RKEKD 344
            |..|:
Yeast   268 RAMKN 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tzn	NP_730568.1	PLN02469	90..347	CDD:178088	93/265 (35%)
		hydroxyacylglutathione_hydrolase_MBL-fold	93..263	CDD:293809	63/175 (36%)
		HAGH_C	264..344	CDD:292741	27/86 (31%)
GLO2	NP_010558.3	hydroxyacylglutathione_hydrolase_MBL-fold	16..188	CDD:293809	63/175 (36%)
GLO2	NP_010558.3	HAGH_C	189..273	CDD:406513	28/88 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343969
Domainoid	1	1.000	113	1.000	Domainoid score	I1343
eggNOG	1	0.900	-	-		E1_COG0491
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1101
Isobase	1	0.950	-	0	Normalized mean entropy	S1406
OMA	1	1.010	-	-		QHG54141
OrthoFinder	1	1.000	-	-		FOG0001231
OrthoInspector	1	1.000	-	-		otm46935
orthoMCL	1	0.900	-	-		OOG6_101019
Panther	1	1.100	-	-	O	PTHR11935
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R494
SonicParanoid	1	1.000	-	-		X446
TreeFam	1	0.960	-	-
	15	14.740