DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and six5

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_571795.1	Gene:	six5 / 65235	ZFINID:	ZDB-GENE-010201-3	Length:	797	Species:	Danio rerio

Alignment Length:	187	Identity:	122/187 - (65%)
Similarity:	150/187 - (80%)	Gaps:	3/187 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPS-EFFKTNESVLRARAMVAYNL 232
            :.||...|  |.|||||:.|:||||.|.|::::|..||.::||| :..:.||::|:|:|:||::.
Zfish    40 LQSFQNSA--LSFSTDQVACLCEALLQAGNVDRLWRFLATIPPSADLLRGNETLLKAQALVAFHR 102

  Fly   233 GQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGE 297
            .:|.|||.:|::|.|....|..||:|:.||.|||||:.|||.||||||||||||:||||||||||
Zfish   103 DEFKELYAILDSHDFHPSNHGFLQDLYLKARYKEAERSRGRSLGAVDKYRLRKKFPLPKTIWDGE 167

  Fly   298 ETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTP 354
            |||||||||||||||:||..||||||.|||.|||.|||:||||||||||||||||||
Zfish   168 ETVYCFKEKSRNALKECYKINRYPTPAEKKNLAKVTGLSLTQVSNWFKNRRQRDRTP 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	59/109 (54%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	47/54 (87%)
six5	NP_571795.1	SIX1_SD	50..160	CDD:293483	59/109 (54%)
six5	NP_571795.1	homeodomain	171..222	CDD:238039	43/50 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7299
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26080
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5881
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.940