DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and six4b

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_571792.2	Gene:	six4b / 65232	ZFINID:	ZDB-GENE-010201-1	Length:	615	Species:	Danio rerio

Alignment Length:	194	Identity:	119/194 - (61%)
Similarity:	148/194 - (76%)	Gaps:	6/194 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLE 243
            |.||.:|:.|:||||.|.|::::|..||.|||.|:..:.|||:|:|:|:||::..::.|||.:||
Zfish    63 LAFSPEQVACVCEALMQGGNVDRLARFLWSLPQSDLLRGNESILKAQAIVAFHHARYQELYCILE 127

  Fly   244 THCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSR 308
            .|.||...|..||::|:||.|.||||.||||||||||||||:|||||:||||||||||||||:||
Zfish   128 NHSFSPSNHSSLQDMWYKARYTEAEKARGRPLGAVDKYRLRRKYPLPRTIWDGEETVYCFKERSR 192

  Fly   309 NALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQQRPDIMSVLPVGQLDGN 372
            |||||.|..||||:|.||:.|||.|||:||||||||||||||||.|.:...      ..:.|||
Zfish   193 NALKDMYKRNRYPSPAEKRNLAKMTGLSLTQVSNWFKNRRQRDRNPSEAQS------KSESDGN 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	61/108 (56%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	42/53 (79%)
six4b	NP_571792.2	SIX1_SD	65..174	CDD:293483	61/108 (56%)
		homeodomain	185..239	CDD:238039	42/53 (79%)
		E_Pc_C	<395..>478	CDD:284226
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26080
orthoMCL	1	0.900	-	-		OOG6_109892
Panther	1	1.100	-	-	O	PTHR10390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	8	8.270