DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and SIX3

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_005404.1	Gene:	SIX3 / 6496	HGNCID:	10889	Length:	332	Species:	Homo sapiens

Alignment Length:	277	Identity:	128/277 - (46%)
Similarity:	170/277 - (61%)	Gaps:	28/277 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 GSSGNLGDLNGNTKTDLCAGLQRSGGGLGGNAGSGGHLISNLTAAHNMSAVSSFPIDAKMLQFST 183
            |:.|..|..||       ||    |||.||..|.||   ....|.....::...|    .|.||.
Human    43 GAGGGSGGGNG-------AG----GGGAGGAGGGGG---GGSRAPPEELSMFQLP----TLNFSP 89

  Fly   184 DQIQCMCEALQQKGDIEKLTTFLCSLPPS----EFFKTNESVLRARAMVAYNLGQFHELYNLLET 244
            :|:..:||.|::.||||:|..||.|||.:    |....:||:|||||:||::.|.|.:||::||.
Human    90 EQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILEN 154

  Fly   245 HCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRN 309
            |.|:.:.|..||.:|.:|||:||||:||||||.|||||:|||:|||:||||||:..:||||::|:
Human   155 HKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRS 219

  Fly   310 ALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR--TPQQRPDIMSVLPVG--QLD 370
            .|::.||.:.||.|.:|:.||:.||||.|||.|||||||||||  ..:.|....::.|.|  .|.
Human   220 LLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLA 284

  Fly   371 GNGFPRMFNAPSYYPET 387
            ..|.|...:|.|  |.|
Human   285 EPGCPTHGSAES--PST 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	60/112 (54%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	32/55 (58%)
SIX3	NP_005404.1	Interaction with TLE5. /evidence=ECO:0000250\|UniProtKB:Q62233	72..119		19/50 (38%)
		SIX1_SD	87..200	CDD:374862	60/112 (54%)
		homeodomain	208..256	CDD:238039	24/47 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..251		10/18 (56%)
		Bind to RHO promoter. /evidence=ECO:0000250\|UniProtKB:Q62233	232..234		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..332		15/44 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810