Protein Alignment Six4 and SIX1

DIOPT Version :10

• Sequence 1: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_005973.1
• Gene: SIX1 / 6495
• HGNCID: 10887
• Length: 284
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 126/255 - (49%)
• Similarity: 153/255 - (60%)
• Gaps: 51/255 - (20%)

  Fly   166 MSAVSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAY 230
            ||.:.||       .|:.:|:.|:||.|||.|::|:|..||.|||..:....|||||:|:|:||:
Human     1 MSMLPSF-------GFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAF 58

  Fly   231 NLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWD 295
            :.|.|.|||.:||:|.||...|..||.||.||||.||||:||||||||.|||:|:|:|||:||||
Human    59 HRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWD 123

  Fly   296 GEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR-------- 352
            ||||.||||||||..|::.|..|.||:|.||:.||:.||||.|||||||||||||||
Human   124 GEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERE 188

  Fly   353 --------------------------------TPQQRPDIMSVLPVGQLDGN-GFPRMFN 379
                                            :|.|.||..|||   .|.|| |..|..|
Human   189 NTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVL---LLQGNMGHARSSN 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	62/108 (57%)
		homeodomain	301..355	CDD:238039	37/93 (40%)
SIX1	NP_005973.1	SIX1_SD	9..118	CDD:465293	62/108 (57%)
		homeodomain	129..180	CDD:238039	35/50 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..269		26/81 (32%)