Protein Alignment Six4 and ANHX

DIOPT Version :10

• Sequence 1: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: XP_006719806.1
• Gene: ANHX / 647589
• HGNCID: 40024
• Length: 492
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 60/220 - (27%)
• Similarity: 86/220 - (39%)
• Gaps: 50/220 - (22%)

  Fly   189 MCEALQQKGDIEKLTTFLCSLPPSEF---FKTNESVLRARAMVAYNLGQFHELYNLLETHCFSIK 250
            :|...|.  |:.:|...:.::..|:.   ...|..|..|.|.|.....|......||| .|....
Human    28 LCRDFQD--DLAQLQPLVTAILDSQLRLHLLDNADVALACARVLDQQEQQQAACRLLE-GCQVPG 89

  Fly   251 YHVDLQNLWFKAHYKEAEKVRG-RPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKE-KSRNALKD 313
            ...:|..||...||:...:..| ..|..|.|:|.||:.|.|.::        |.:. ||||..::
Human    90 GSQELVQLWNDIHYRLVMRRLGVAALTPVQKFRCRKRNPPPPSL--------CPEGLKSRNFPRE 146

  Fly   314 --------CYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRT------PQQR------- 357
                    ....|..|:..|::.||.:|.||..||.|||.|.|:|.|.      |.|:
Human   147 VREKLHNFAVGVNTNPSKAERENLALETSLTPEQVYNWFANYRRRQRALPQHMKPAQQATAEDPG 211

  Fly   358 -----PDIMSVLPVGQLDGNGFPRM 377
                 ||::      |..||  ||:
Human   212 ARERGPDLL------QPSGN--PRV 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	28/104 (27%)
		homeodomain	301..355	CDD:238039	22/68 (32%)
ANHX	XP_006719806.1	SIX1_SD	<93..130	CDD:465293	13/36 (36%)
		homeodomain	139..193	CDD:238039	20/53 (38%)