DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and six2b

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001122206.1	Gene:	six2b / 566454	ZFINID:	ZDB-GENE-080723-23	Length:	285	Species:	Danio rerio

Alignment Length:	177	Identity:	111/177 - (62%)
Similarity:	135/177 - (76%)	Gaps:	0/177 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 FSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLETH 245
            |:.:|:.|:||.|||.|.||:|..||.|||..|....|||||:|:|:||::.|.|.|||.:||:|
Zfish     9 FTQEQVACVCEVLQQGGSIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKVLESH 73

  Fly   246 CFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNA 310
            .||...|..||.||.||||.||||:||||||||.|||:|:|:|||::|||||||.||||||||..
Zfish    74 QFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRCV 138

  Fly   311 LKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQQR 357
            ||:.|..|.||:|.||:.||:.||||.|||||||||||||||..:.:
Zfish   139 LKEWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	64/108 (59%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	38/53 (72%)
six2b	NP_001122206.1	SIX1_SD	9..118	CDD:293483	64/108 (59%)
six2b	NP_001122206.1	homeodomain	129..180	CDD:238039	36/50 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001063
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810