Protein Alignment Six4 and SIX4

DIOPT Version :9

• Sequence 1: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_059116.3
• Gene: SIX4 / 51804
• HGNCID: 10890
• Length: 781
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 138/284 - (48%)
• Similarity: 171/284 - (60%)
• Gaps: 41/284 - (14%)

  Fly    96 SPPPTASTTPTHYPSLNSIIFENGSSGNLGDLNGNTKTDLCAGLQRSGGGLG-------GNAGSG 153
            |||     .|..:|      .|.|              |......|..|..|       |.|...
Human    44 SPP-----APAPFP------LEPG--------------DAATAAARVSGEEGAVAAAAAGAAADQ 83

  Fly   154 GHLISNLTAAHNMSAVSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTN 218
            ..|.|.|...|:.:|.::....   |.||.|.:.|:||||||.|::::|..||.|||.|:..:.|
Human    84 VQLHSELLGRHHHAAAAAAQTP---LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGN 145

  Fly   219 ESVLRARAMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRL 283
            ||:|:|||:||::.|.:.|||::||:|.|....|..||.||:||.|.|||:.|||||||||||||
Human   146 ESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRL 210

  Fly   284 RKKYPLPKTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRR 348
            |:|:|||:|||||||||||||||||||||:.|..||||:|.||:.|||.|||:||||||||||||
Human   211 RRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRR 275

  Fly   349 QRDRTPQQRPDIMSVLPVGQLDGN 372
            ||||.|.:...      ..:.|||
Human   276 QRDRNPSETQS------KSESDGN 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	62/108 (57%)
		homeodomain	301..355	CDD:238039	42/53 (79%)
SIX4	NP_059116.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		5/21 (24%)
		SIX1_SD	108..217	CDD:293483	62/108 (57%)
		homeodomain	228..282	CDD:238039	42/53 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..321		14/30 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158077
Domainoid	1	1.000	88	1.000	Domainoid score	I7947
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41533
orthoMCL	1	0.900	-	-		OOG6_109892
Panther	1	1.100	-	-	O	PTHR10390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.700