DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and Six5

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001359006.1	Gene:	Six5 / 308406	RGDID:	1305040	Length:	720	Species:	Rattus norvegicus

Alignment Length:	219	Identity:	123/219 - (56%)
Similarity:	152/219 - (69%)	Gaps:	18/219 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLE 243
            |:||.:|:.|:||||.|.|...:|:.||.:|||:|..:.::.||||||:||:..|::.|||.|||
  Rat    76 LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLE 140

  Fly   244 THCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSR 308
            :..|...:|..||:|:.:|.|.|||:.|||.||||||||||||:||||||||||||||||||:||
  Rat   141 SRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSR 205

  Fly   309 NALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRT------PQQRPDIMSVLPVG 367
            .|||.||..|||||||||:.||..|||:|||||||||||||||||      |.:          .
  Rat   206 AALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCK----------S 260

  Fly   368 QLDGNGFPRMFNAPSYYPETIFNG 391
            :.|||  |...:..|..||.:..|
  Rat   261 ESDGN--PTTEDESSRSPEDLERG 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	58/108 (54%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	43/59 (73%)
Six5	NP_001359006.1	SIX1_SD	78..187	CDD:374862	58/108 (54%)
		homeodomain	198..249	CDD:238039	40/50 (80%)
		PHA03247	<414..652	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010