Protein Alignment Six4 and Six5

DIOPT Version :10

• Sequence 1: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_035513.1
• Gene: Six5 / 20475
• MGIID: 106220
• Length: 719
• Species: Mus musculus
• Alignment Length: 219
• Identity: 123/219 - (56%)
• Similarity: 152/219 - (69%)
• Gaps: 18/219 - (8%)

  Fly   179 LQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLE 243
            |:||.:|:.|:||||.|.|...:|:.||.:|||:|..:.::.||||||:||:..|::.|||.|||
Mouse    77 LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLE 141

  Fly   244 THCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSR 308
            :..|...:|..||:|:.:|.|.|||:.|||.||||||||||||:||||||||||||||||||:||
Mouse   142 SRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSR 206

  Fly   309 NALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRT------PQQRPDIMSVLPVG 367
            .|||.||..|||||||||:.||..|||:|||||||||||||||||      |.:          .
Mouse   207 AALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCK----------S 261

  Fly   368 QLDGNGFPRMFNAPSYYPETIFNG 391
            :.|||  |...:..|..||.:..|
Mouse   262 ESDGN--PTTEDESSRSPEDLERG 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	58/108 (54%)
		homeodomain	301..355	CDD:238039	43/59 (73%)
Six5	NP_035513.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73
		SIX1_SD	79..188	CDD:465293	58/108 (54%)
		homeodomain	199..250	CDD:238039	40/50 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..287		20/55 (36%)
		PHA03247	<380..651	CDD:223021