DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and Six5

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_035513.1	Gene:	Six5 / 20475	MGIID:	106220	Length:	719	Species:	Mus musculus

Alignment Length:	219	Identity:	123/219 - (56%)
Similarity:	152/219 - (69%)	Gaps:	18/219 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLE 243
            |:||.:|:.|:||||.|.|...:|:.||.:|||:|..:.::.||||||:||:..|::.|||.|||
Mouse    77 LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLE 141

  Fly   244 THCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSR 308
            :..|...:|..||:|:.:|.|.|||:.|||.||||||||||||:||||||||||||||||||:||
Mouse   142 SRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSR 206

  Fly   309 NALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRT------PQQRPDIMSVLPVG 367
            .|||.||..|||||||||:.||..|||:|||||||||||||||||      |.:          .
Mouse   207 AALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCK----------S 261

  Fly   368 QLDGNGFPRMFNAPSYYPETIFNG 391
            :.|||  |...:..|..||.:..|
Mouse   262 ESDGN--PTTEDESSRSPEDLERG 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	58/108 (54%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	43/59 (73%)
Six5	NP_035513.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		SIX1_SD	79..188	CDD:293483	58/108 (54%)
		homeodomain	199..250	CDD:238039	40/50 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..287		20/55 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43583
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5881
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900