DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and Six4

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_035512.1	Gene:	Six4 / 20474	MGIID:	106034	Length:	775	Species:	Mus musculus

Alignment Length:	277	Identity:	136/277 - (49%)
Similarity:	170/277 - (61%)	Gaps:	34/277 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SPPPTASTTPTHYPSLNSIIFENGSSGNLGDLNGNTKTDLCAGLQRSGGGLGGNAGSGGHLISNL 160
            |||     .|..:|      .|.|.:.            ..:.:.|..|.....|.....|.|.|
Mouse    44 SPP-----APAPFP------LEPGDAA------------AASRVSREEGAAAAGAADQVQLHSEL 85

  Fly   161 TAAHNMSAVSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRAR 225
            ...|..:|.:..|     |.||.|.:.|:||||||.|::::|..||.|||.|:..:.|||:|:||
Mouse    86 LGRHQHAAAAQPP-----LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKAR 145

  Fly   226 AMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLP 290
            |:||::.|.:.|||::||:|.|....|..||.||:||.|.|||:.||||||||||||||:|:|||
Mouse   146 ALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLP 210

  Fly   291 KTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQ 355
            :|||||||||||||||||||||:.|..||||:|.||:.|||.|||:||||||||||||||||.|.
Mouse   211 RTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPS 275

  Fly   356 QRPDIMSVLPVGQLDGN 372
            :...      ..:.|||
Mouse   276 ETQS------KSESDGN 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	62/108 (57%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	42/53 (79%)
Six4	NP_035512.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		7/31 (23%)
		SIX1_SD	101..210	CDD:293483	47/108 (44%)
		homeodomain	221..275	CDD:238039	44/53 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..313		31/49 (63%)
		Transactivation domain	582..775
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848461
Domainoid	1	1.000	88	1.000	Domainoid score	I7952
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43583
orthoMCL	1	0.900	-	-		OOG6_109892
Panther	1	1.100	-	-	O	PTHR10390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3257
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.700