Protein Alignment Six4 and Six4

DIOPT Version :10

• Sequence 1: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_035512.1
• Gene: Six4 / 20474
• MGIID: 106034
• Length: 775
• Species: Mus musculus
• Alignment Length: 277
• Identity: 136/277 - (49%)
• Similarity: 170/277 - (61%)
• Gaps: 34/277 - (12%)

  Fly    96 SPPPTASTTPTHYPSLNSIIFENGSSGNLGDLNGNTKTDLCAGLQRSGGGLGGNAGSGGHLISNL 160
            |||     .|..:|      .|.|.:.            ..:.:.|..|.....|.....|.|.|
Mouse    44 SPP-----APAPFP------LEPGDAA------------AASRVSREEGAAAAGAADQVQLHSEL 85

  Fly   161 TAAHNMSAVSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRAR 225
            ...|..:|.:..|     |.||.|.:.|:||||||.|::::|..||.|||.|:..:.|||:|:||
Mouse    86 LGRHQHAAAAQPP-----LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKAR 145

  Fly   226 AMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLP 290
            |:||::.|.:.|||::||:|.|....|..||.||:||.|.|||:.||||||||||||||:|:|||
Mouse   146 ALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLP 210

  Fly   291 KTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQ 355
            :|||||||||||||||||||||:.|..||||:|.||:.|||.|||:||||||||||||||||.|.
Mouse   211 RTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPS 275

  Fly   356 QRPDIMSVLPVGQLDGN 372
            :...      ..:.|||
Mouse   276 ETQS------KSESDGN 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	62/108 (57%)
		homeodomain	301..355	CDD:238039	42/53 (79%)
Six4	NP_035512.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		7/31 (23%)
		SIX1_SD	101..210	CDD:465293	47/108 (44%)
		homeodomain	221..275	CDD:238039	44/53 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..313		31/49 (63%)
		Transactivation domain	582..775