DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Six4 and ceh-33

DIOPT Version :9

Sequence 1:	NP_649256.1	Gene:	Six4 / 40297	FlyBaseID:	FBgn0027364	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_504420.1	Gene:	ceh-33 / 191622	WormBaseID:	WBGene00000454	Length:	261	Species:	Caenorhabditis elegans

Alignment Length:	179	Identity:	95/179 - (53%)
Similarity:	131/179 - (73%)	Gaps:	2/179 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 QFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQFHELYNLLET 244
            ::|.:|:.|:||||  ..|..||:.|:.::...:..:.|:.:|:|:|.:|::...|.|||.::|:
Worm    19 RYSEEQVACICEAL--SNDARKLSQFVWTVLERDEMRNNQYILKAQAFLAFHSNNFKELYRIIES 81

  Fly   245 HCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRN 309
            |.|:.::|:.||..|..|||.||||:|||.||||.|||:|:|||||:||||||||.|||::|||.
Worm    82 HHFASEHHLPLQEWWLNAHYHEAEKIRGRQLGAVGKYRIRRKYPLPRTIWDGEETSYCFRDKSRV 146

  Fly   310 ALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQQRP 358
            .|:|.|..|.||:|.||:.||:||.||:|||||||||||||||.....|
Worm   147 LLRDWYCRNSYPSPREKRELAEKTHLTVTQVSNWFKNRRQRDRAGVPEP 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	48/108 (44%)
Six4	NP_649256.1	homeodomain	301..355	CDD:238039	36/53 (68%)
ceh-33	NP_504420.1	SIX1_SD	20..127	CDD:293483	48/108 (44%)
ceh-33	NP_504420.1	homeodomain	138..189	CDD:238039	34/50 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001063
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.770