DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11399 and PCIF1

DIOPT Version :9

Sequence 1:NP_649254.2 Gene:CG11399 / 40295 FlyBaseID:FBgn0037021 Length:920 Species:Drosophila melanogaster
Sequence 2:NP_071387.1 Gene:PCIF1 / 63935 HGNCID:16200 Length:704 Species:Homo sapiens


Alignment Length:736 Identity:312/736 - (42%)
Similarity:442/736 - (60%) Gaps:82/736 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 GAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGPPTLGPGGYGEELTA 137
            |:|.....:|..:.|....|.|   ||          |.|:..:                ::|..
Human     7 GSPREEASLLSHSPGTSNQSQP---CS----------PKPIRLV----------------QDLPE 42

  Fly   138 ELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGICHAGGP-------TPIIP 195
            |||:.||.|.||:|||||||:|:.|.:||||||.....|.::||||:.....|       ||...
Human    43 ELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAE 107

  Fly   196 NMHQQQQHQHHHLK----RRPSDDMHIH------PNQHHMGGGPPMKKF----------VLAGP- 239
            |..:::|.......    ::|..::.:.      |:...:.|.|.:|.:          .|..| 
Human   108 NKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPT 172

  Fly   240 ---WDLEVCTNAVIVERPPTLLPQPHPEVEALRAAFTMKLLKTYEDLCMRRENIKAPRDSFNRWL 301
               |||::.|||||..|.|:.:..||||||.||:...:||.:.|.:||.:||.|:.||:|||||:
Human   173 EVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWM 237

  Fly   302 MERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIPIKIVKPKFTGDARKQLSRYAEAAKQIIESR 366
            :||||:|.|.||||||:|.|.:|.||:||||:||||::.:.||..:|::.|.:|||||:::||||
Human   238 LERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESR 302

  Fly   367 SAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDRLAHLKRQCEPHLVETVKSSVETLCVKIYHL 431
            ||..:|:|||||||||||.|||:...||.||:.|||.||:|||.||:....|.|||.:|.||||:
Human   303 SASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHI 367

  Fly   432 SADHARKIRERHSQLLKEHGIPEPTPPPP-PPHLKKVWCYPIQFAVPSPRMPTIEYLQDRDHMII 495
            |.::.::|||:|..:|||:.|.|....|. .|.|  |:|||::.||.:|.||::|...:.:.:.|
Human   368 SLEYVKRIREKHLAILKENNISEEVEAPEVEPRL--VYCYPVRLAVSAPPMPSVEMHMENNVVCI 430

  Fly   496 KYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKKFDLFIGRVWCLLKRYQTFLGNALNSSQEA 560
            :|....:.      ::..|..||..|||::|.||..|:.|:.||||||:|||...|..|   .|.
Human   431 RYKGEMVK------VSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGL---YEG 486

  Fly   561 ELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQYCSAFADTDAYFGSRGPFLDFKPVSGSFQ 625
            ...|.:|||.|||.|||.|||||||||||.|.|||||||||.|||.|||||||.|||.|:||||:
Human   487 TGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFE 551

  Fly   626 VNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPEWK-----SISKLDDSMYKRRSMVVLGMAH 685
            .|||.||||::|.:.|.::||..:.||||||||:|||:     ::::::.|.:||..:::....|
Human   552 ANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEH 616

  Fly   686 EYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRPQRDRERERAAAA 750
            |||.|.||:.:|.::..|.:..|.|::|||..|:|:|.|...|::.|..|:| |..|.....:::
Human   617 EYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYR-QSGRSHSSGSSS 680

  Fly   751 AAAAGV----TSSQQSPSTPP 767
            ::::..    :..:|.||..|
Human   681 SSSSEAKDRDSGREQGPSREP 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11399NP_649254.2 WW 143..170 CDD:238122 18/26 (69%)
PCIF1_WW 524..685 CDD:289041 91/165 (55%)
PCIF1NP_071387.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 9/38 (24%)
WW 47..77 CDD:238122 20/29 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..151 9/62 (15%)
Nuclear localization signal. /evidence=ECO:0000255 109..113 0/3 (0%)
PCIF1_WW 446..616 CDD:403450 96/172 (56%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000269|PubMed:30467178, ECO:0007744|PDB:6IRW 553..556 2/2 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:A0A0R4IKJ1 588..592 1/3 (33%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000269|PubMed:30467178, ECO:0007744|PDB:6IRW 614..616 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 663..704 9/40 (23%)
Nuclear localization signal. /evidence=ECO:0000255 669..684 2/14 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144858
Domainoid 1 1.000 287 1.000 Domainoid score I1597
eggNOG 1 0.900 - - E1_28P6D
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11134
Inparanoid 1 1.050 585 1.000 Inparanoid score I1009
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52676
OrthoDB 1 1.010 - - D114954at33208
OrthoFinder 1 1.000 - - FOG0007279
OrthoInspector 1 1.000 - - oto89567
orthoMCL 1 0.900 - - OOG6_106120
Panther 1 1.100 - - LDO PTHR21727
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5561
SonicParanoid 1 1.000 - - X5383
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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