Protein Alignment Pcif1 and PCIF1

DIOPT Version :10

• Sequence 1: NP_649254.2
• Gene: Pcif1 / 40295
• FlyBaseID: FBgn0037021
• Length: 920
• Species: Drosophila melanogaster
• Sequence 2: NP_071387.1
• Gene: PCIF1 / 63935
• HGNCID: 16200
• Length: 704
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 312/736 - (42%)
• Similarity: 442/736 - (60%)
• Gaps: 82/736 - (11%)

  Fly    73 GAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGPPTLGPGGYGEELTA 137
            |:|.....:|..:.|....|.|   ||          |.|:..:                ::|..
Human     7 GSPREEASLLSHSPGTSNQSQP---CS----------PKPIRLV----------------QDLPE 42

  Fly   138 ELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGICHAGGP-------TPIIP 195
            |||:.||.|.||:|||||||:|:.|.:||||||.....|.::||||:.....|       ||...
Human    43 ELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAE 107

  Fly   196 NMHQQQQHQHHHLK----RRPSDDMHIH------PNQHHMGGGPPMKKF----------VLAGP- 239
            |..:::|.......    ::|..::.:.      |:...:.|.|.:|.:          .|..|
Human   108 NKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPT 172

  Fly   240 ---WDLEVCTNAVIVERPPTLLPQPHPEVEALRAAFTMKLLKTYEDLCMRRENIKAPRDSFNRWL 301
               |||::.|||||..|.|:.:..||||||.||:...:||.:.|.:||.:||.|:.||:|||||:
Human   173 EVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWM 237

  Fly   302 MERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIPIKIVKPKFTGDARKQLSRYAEAAKQIIESR 366
            :||||:|.|.||||||:|.|.:|.||:||||:||||::.:.||..:|::.|.:|||||:::||||
Human   238 LERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESR 302

  Fly   367 SAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDRLAHLKRQCEPHLVETVKSSVETLCVKIYHL 431
            ||..:|:|||||||||||.|||:...||.||:.|||.||:|||.||:....|.|||.:|.||||:
Human   303 SASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHI 367

  Fly   432 SADHARKIRERHSQLLKEHGIPEPTPPPP-PPHLKKVWCYPIQFAVPSPRMPTIEYLQDRDHMII 495
            |.::.::|||:|..:|||:.|.|....|. .|.|  |:|||::.||.:|.||::|...:.:.:.|
Human   368 SLEYVKRIREKHLAILKENNISEEVEAPEVEPRL--VYCYPVRLAVSAPPMPSVEMHMENNVVCI 430

  Fly   496 KYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKKFDLFIGRVWCLLKRYQTFLGNALNSSQEA 560
            :|....:.      ::..|..||..|||::|.||..|:.|:.||||||:|||...|..|   .|.
Human   431 RYKGEMVK------VSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGL---YEG 486

  Fly   561 ELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQYCSAFADTDAYFGSRGPFLDFKPVSGSFQ 625
            ...|.:|||.|||.|||.|||||||||||.|.|||||||||.|||.|||||||.|||.|:||||:
Human   487 TGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFE 551

  Fly   626 VNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPEWK-----SISKLDDSMYKRRSMVVLGMAH 685
            .|||.||||::|.:.|.::||..:.||||||||:|||:     ::::::.|.:||..:::....|
Human   552 ANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEH 616

  Fly   686 EYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRPQRDRERERAAAA 750
            |||.|.||:.:|.::..|.:..|.|::|||..|:|:|.|...|::.|..|:| |..|.....:::
Human   617 EYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYR-QSGRSHSSGSSS 680

  Fly   751 AAAAGV----TSSQQSPSTPP 767
            ::::..    :..:|.||..|
Human   681 SSSSEAKDRDSGREQGPSREP 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcif1	NP_649254.2	WW	143..170	CDD:459800	18/26 (69%)
		PCIF1_WW	517..685	CDD:463502	96/172 (56%)
PCIF1	NP_071387.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		9/38 (24%)
		WW	47..77	CDD:238122	20/29 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..151		9/62 (15%)
		Nuclear localization signal. /evidence=ECO:0000255	109..113		0/3 (0%)
		PCIF1_WW	446..616	CDD:463502	96/172 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..704		9/40 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	669..684		2/14 (14%)