DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11399 and pcif1

DIOPT Version :9

Sequence 1:	NP_649254.2	Gene:	CG11399 / 40295	FlyBaseID:	FBgn0037021	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	XP_688220.3	Gene:	pcif1 / 553360	ZFINID:	ZDB-GENE-120920-2	Length:	721	Species:	Danio rerio

Alignment Length:	780	Identity:	315/780 - (40%)
Similarity:	439/780 - (56%)	Gaps:	126/780 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TASASNNMSPSPTAGAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGP 123
            |..|.:.:..|||                   ||:..|:..||||      ..|:
Zfish     8 TIKADSALVMSPT-------------------GSTSQAAPFSPST------SKPI---------- 37

  Fly   124 PTLGPGGYGEELTAELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGI--CH 186
                     :||..||:..||.|.||||||||||:|:.|.:||||||.....|.::||||:  ..
Zfish    38 ---------QELPDELIQAGWSKCWSKRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNAAP 93

  Fly   187 AGGPTPIIPNMHQQQQHQHHHLKRRPSDD------------------------MHIHPNQHHMGG 227
            |.|.......:...|:      ||.||:|                        :.|.|:.
Zfish    94 ASGEANADAGLGNGQR------KRHPSEDASQAGPNSFKRPKVEIPATPTTPTVPISPST----- 147

  Fly   228 GPPMKKFV--------------LAGP-------WDLEVCTNAVIVERPPTLLPQPHPEVEALRAA 271
             |.:|.:|              ...|       |||::.|||||.||.|.....||||:|..||.
Zfish   148 -PGVKPWVNTTTDEKQGQASTPAPAPYRPSVVYWDLDIQTNAVIRERAPADHLPPHPEIELQRAQ 211

  Fly   272 FTMKLLKTYEDLCMRRENIKAPRDSFNRWLMERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIP 336
            .|.||.:.|.:||.:||.|:.||:||||||:||||:|.|.||||||.|.|.||.||:||||:|||
Zfish   212 LTTKLRQHYHELCSQREGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIP 276

  Fly   337 IKIVKPKFTGDARKQLSRYAEAAKQIIESRSAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDR 401
            |::.:.|:..:|||.|.:||||||::|:||:|..||:||||||||||..||||...||.||:.||
Zfish   277 IRLSRIKYKEEARKLLFKYAEAAKKMIDSRNATPESRKVVKWNVEDTMNWLRRDHSASKEDYMDR 341

  Fly   402 LAHLKRQCEPHLVETVKSSVETLCVKIYHLSADHARKIRERHSQLLKEHGIPEPTPPPPPPHLKK 466
            |.||::||.||:....|.|||.:|.||||:||::.|:||:.|..||||..|............:.
Zfish   342 LEHLRKQCGPHVASVAKDSVEGICSKIYHISAEYVRRIRQAHLTLLKECNISVDGTESAEVQDRL 406

  Fly   467 VWCYPIQFAVPSPRMPTIEYLQDRDHMIIKYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKK 531
            |:|||::.::|:|....:|...:.|...:::....:.      ::..:..|||.|||::|.||.:
Zfish   407 VYCYPVRLSIPAPPQTRVELHFENDIACLRFKGEMVK------VSRGHFNKLELLYRYSCIDDPR 465

  Fly   532 FDLFIGRVWCLLKRYQTFLGNALNSSQEAELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQ 596
            |:.|:.|||||:||||...|:.:|   |....|.:|||||||.|::||||:|||||||.|.||:|
Zfish   466 FEKFLSRVWCLIKRYQVMFGSGVN---EGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQ 527

  Fly   597 YCSAFADTDAYFGSRGPFLDFKPVSGSFQVNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPE 661
            :||||.|.|.:||||||||.|.|.||||:.|||.||||::|.:.|.:.||..:.||||||:|:||
Zfish   528 FCSAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEELMDAMVTHFEDLLGRSSEPLSFIIFVPE 592

  Fly   662 WK-----SISKLDDSMYKRRSMVVLGMAHEYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYAR 721
            |:     ::::::.|.::|..|.|....||||.|.||:.::.::..|.:.||.|::|||:||:|:
Zfish   593 WRDPPTPALTRMEASRFRRHQMTVPAFEHEYRSGSQHICKREEIYYKAIHGTAVIFLQNNAGFAK 657

  Fly   722 WGPNEIRVEALREAFRPQRDRERERAAAAAAAAGVTSSQQSPS-TPPSAASTAP-------TTNS 778
            |.|...|::.|..|::.. .|.......::...|...|:.:|. |.||..:::|       |||:
Zfish   658 WEPTTERIQELLAAYKVS-GRSLPSPGPSSTNTGEKDSKPAPERTAPSQDNSSPVDKTAQDTTNT 721

Fly 779 778
Zfish 722 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11399	NP_649254.2	WW	143..170	CDD:238122	19/26 (73%)
CG11399	NP_649254.2	PCIF1_WW	524..685	CDD:289041	86/165 (52%)
pcif1	XP_688220.3	WW	47..77	CDD:238122	21/29 (72%)
pcif1	XP_688220.3	PCIF1_WW	464..621	CDD:315010	83/159 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578069
Domainoid	1	1.000	276	1.000	Domainoid score	I1712
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11134
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1026
OMA	1	1.010	-	-		QHG52676
OrthoDB	1	1.010	-	-		D114954at33208
OrthoFinder	1	1.000	-	-		FOG0007279
OrthoInspector	1	1.000	-	-		oto39179
orthoMCL	1	0.900	-	-		OOG6_106120
Panther	1	1.100	-	-	LDO	PTHR21727
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910